Pyrazofurin

MCE 国际站：Pyrazofurin

CAS：30868-30-5

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Pyrazofurin 是一种具有抗肿瘤活性的嘧啶核苷类似物，通过抑制 uridine 5'-phosphate (UMP) 合酶^[1] 抑制细胞增殖和细胞内 DNA 合成。 Pyrazofurin 是一种活性、敏感的乳清酸磷酸核糖基转移酶抑制剂，在三种鳞状细胞癌 (SCC) 细胞中的 IC₅₀ 介于 0.06-0.37 μM 之间线 Hep-2、HNSCC-14B 和 HNSCC-14C^[2]。

热销产品：Dacinostat  | KH-4-43  | 3'-Hydroxypterostilbene  | Posaconazole  | GW 501516  | Gambogic Acid  | Streptomycin  | Gastrodin  | eGFP mRNA-LNP  | Bococizumab

研究领域：Cell Cycle/DNA Damage

作用靶点：DNA/RNA Synthesis

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6(1):19-27.

[2]. Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):329-339.