N-Acetyl-D-cysteine

MCE 国际站：N-Acetyl-D-cysteine

CAS：26117-28-2

品牌：MedChemExpress (MCE)

存储条件：4°C, stored under nitrogen

生物活性：N-乙酰-D-半胱氨酸具有抗氧化活性，通过与其巯基反应清除ROS，但不能进入谷胱甘肽代谢途径^[1]。  

体外：N-乙酰-D-半胱氨酸（20 mM；1 小时预处理；12 小时）不会增加细胞内 GSH 水平，但 GSH 单酯会。 D-NAC不能增强缺氧细胞凋亡。这表明 GSH 而不是 D-NAC 或 NAC 负责增强缺氧细胞凋亡^[3]。

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研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Maika Deffieu, et al. Glutathione Participates in the Regulation of Mitophagy in Yeast.J Biol Chem. 2009 May 29;284(22):14828-37.

[2]. B K Wong,et al. Selective Effects of N-acetylcysteine Stereoisomers on Hepatic Glutathione and Plasma Sulfate in Mice. Toxicol Appl Pharmacol

[3]. Suparna Qanungo, et al. N-Acetyl-L-cysteine Enhances Apoptosis Through Inhibition of Nuclear factor-kappaB in Hypoxic Murine Embryonic Fibroblasts. J Biol Chem