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MCE 国际站:N-Acetyl-D-cysteine
CAS:26117-28-2
品牌:MedChemExpress (MCE)
存储条件:4°C, stored under nitrogen
生物活性:N-乙酰-D-半胱氨酸具有抗氧化活性,通过与其巯基反应清除ROS,但不能进入谷胱甘肽代谢途径[1]。
体外:N-乙酰-D-半胱氨酸(20 mM;1 小时预处理;12 小时)不会增加细胞内 GSH 水平,但 GSH 单酯会。 D-NAC不能增强缺氧细胞凋亡。这表明 GSH 而不是 D-NAC 或 NAC 负责增强缺氧细胞凋亡[3]。
热销产品:Ezetimibe | L-Leucine | PF-9366 | NSC 74859 | Psoralidin | Midostaurin | S100A4, Mouse (His) | Tetrakis(triphenylphosphine)palladium | Atorvastatin | UNC1999
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Maika Deffieu, et al. Glutathione Participates in the Regulation of Mitophagy in Yeast.J Biol Chem. 2009 May 29;284(22):14828-37.
[2]. B K Wong,et al. Selective Effects of N-acetylcysteine Stereoisomers on Hepatic Glutathione and Plasma Sulfate in Mice. Toxicol Appl Pharmacol
[3]. Suparna Qanungo, et al. N-Acetyl-L-cysteine Enhances Apoptosis Through Inhibition of Nuclear factor-kappaB in Hypoxic Murine Embryonic Fibroblasts. J Biol Chem
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