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Polymyxin B nonapeptide | 多粘菌素B九肽
MCE 国际站:Polymyxin B nonapeptide
中文名:多粘菌素B九肽
CAS:86408-36-8
品牌:MedChemExpress (MCE)
存储条件:Protect from light.Powder: -80°C, 2 years; -20°C, 1 year.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:多粘菌素 B 九肽是多粘菌素 B 通过蛋白水解去除其末端氨基酰基残基而获得的环状肽[1]。多粘菌素 B 九肽毒性较低,缺乏杀菌活性,并保留其通过透化外膜使革兰氏阴性菌对多种抗生素敏感的能力[2]。
体外:多粘菌素 B 九肽是一种阳离子环肽,通过酶促加工从天然存在的肽多粘菌素 B 中提取,能够增加革兰氏阴性菌外膜对疏水性抗生素的渗透性,可能是通过与细菌脂多糖 (LPS) 结合[1]。
热销产品:Cilostamide | Glufosinate (ammonium) | Cimifugin | Onvatilimab | Coumetarol | Flucloxacillin sodium | Benzalkonium (chloride) | Oxotremorine M (iodide) | Nefazodone | PACMA 31
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92
[2]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.
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