|
MCE 国际站:CL075
CAS:256922-53-9
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:CL075 (3M002) 是一种具有免疫调节特性的选择性 TLR8 激动剂。 CL075 触发 MyD88 依赖性信号通路,分别通过激活 NF-κB 和 IRF7 引发炎症细胞因子和 I 型干扰素 (IFN) 的产生[1][2][3]。 IC50 和目标:TLR8[1]
体外:CL075 (2 μM; 4 h) 诱导兔脾细胞产生 IL-6、IL-8 和 IFN-γ[1]。CL075 (2 μM; 48 h)在兔脾细胞中诱导总 IgM 产生和细胞增殖[1]。CL075(2 μM;7 小时)在 293 个细胞中激活 rabTLR8[1] .
体内:CL075(5 μM(0.5 mL);sc)在兔体内激活轻微的抗原特异性抗体反应[1]。
热销产品:Venlafaxine (hydrochloride) | Tesofensine | DCVC | N-Succinimidyl-S-acetylthioacetate | Amoxicillin (sodium) | N,N-Dimethylacetamide | Ecdysone | (S)-(+)-N-3-Benzylnirvanol | CR-1-31-B | Lipoteichoic acid
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9.
[2]. Spranger S, et, al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010 Jul 1;185(1):738-47.
[3]. Maalej KM, et, al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015 Jun;97(6):1081-7.
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-9-27 23:29
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社