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MCE 国际站:Zanidatamab
CAS:2169946-15-8
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Zanidatamab (ZW25) 是一种针对 2 个不同 HER2 表位 (ECD2 和 ECD4) 的人源双特异性单克隆抗体。Zanidatamab 具有抗肿瘤活性。
体外:Zanidatamab (ZW25) 对重组 HER2 和具有一定 HER2 表达的培养癌细胞具有低 nM 结合亲和力 (0.9-16 nM)[1]。 Zanidatamab 可抑制 HER2 广泛表达的人类癌细胞系的生长 (5-54% 的抑制取决于细胞系),并抑制配体介导的肿瘤细胞增殖[1]。 Zanidatamab 在nM 浓度下 (0.05-64 nM) 诱导浓度依赖的 ADCC,在表达 HER2 的 TNBC 细胞系上最大裂解率可达 52%,并在各种 HER2 表达肿瘤细胞系中与多种化疗药物 (包括铂类、紫杉烷类、微管抑制剂和 DNA 合成抑制剂) 表现出协同作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内:Zanidatamab (ZW25) 诱导显著的肿瘤消退,表现出相对于 hIgG 对照 307% 的肿瘤生长抑制和 70% 的完全消退率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Clinical Trial
热销产品:Nourseothricin (sulfate) | NE 52-QQ57 | DIM-C-pPhCO2Me | Bazedoxifene | BQ-788 (sodium salt) | Chelerythrine (chloride) | L-Palmitoylcarnitine (chloride) | Bax inhibitor peptide V5 | Mavacamten | Prednisone
研究领域:JAK/STAT Signaling | Protein Tyrosine Kinase/RTK
作用靶点:EGFR
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Weisser N, et, al. Preclinical development of a novel biparatopic HER2 antibody with activity in low to high HER2 expressing cancers. Cancer Res. 2017:77 (13).
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