Clavulanic acid | 克拉维酸

MCE 国际站：Clavulanic acid

中文名：克拉维酸

CAS：58001-44-8

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light, stored under nitrogen

生物活性：克拉维酸是一种天然存在的强效细菌 β-内酰胺酶 抑制剂，用于研究由细菌引起的感染，包括耳朵感染。克拉维酸对多种革兰氏阳性和革兰氏阴性细菌均有活性^[1]。

体外：Clavulanic acid 与氨苄西林具有协同抗菌作用 (针对产生 β-内酰胺酶的微生物)[2]。 Clavulanic acid 抑制 Ab11 和 Ab51 菌株，MIC 为 2-8 μg/mL[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Clavulanic acid (13 mg/kg，腹膜内注射) 可降低感染鲍曼不动杆菌的C57BL/6小鼠肺炎模型肺内的细菌负荷[3]。 Clavulanic acid (13 mg/kg，腹腔注射) 在 Ab51 感染的 C57BL/6 小鼠肺炎模型中显示 t1/2 为 6.69 h，AUC 为 4.03 mg·h/L[3]。 Clavulanic acid (100-300 mg/kg，腹腔注射) 对 Carrageenan (HY-125474) 诱导的足水肿大鼠模型具有抗炎作用[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Clinical Trial

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研究领域：Anti-infection

作用靶点：Beta-lactamase  |  Antibiotic  |  Bacterial

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参考文献：[1]. Parag S Saudagar, et al. Clavulanic acid: a review. Biotechnol Adv. Jul-Aug 2008;26(4):335-51

[2]. Neu HC, et al. Clavulanic acid, a novel inhibitor of beta-lactamases. Antimicrob Agents Chemother. 1978 Nov;14(5):650-5.

[3]. Beceiro A,et al. In vitro activity and in vivo efficacy of clavulanic acid against Acinetobacter baumannii. Antimicrob Agents Chemother. 2009 Oct;53(10):4298-304.

[4]. Soyocak A, et al. Tannic acid exhibits anti-inflammatory effects on formalin-induced paw edema model of inflammation in rats. Hum Exp Toxicol. 2019 Nov;38(11):1296-1301.