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Isosilybin A 是一种从水飞蓟素中分离出来的黄酮木脂素 |MedChemExpress (MCE)
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MCE 国际站：Isosilybin A
中文名：异水飞蓟宾A
CAS：142796-21-2
品牌：MedChemExpress (MCE)
存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性：Isosilybin A 是一种从水飞蓟素中分离出来的黄酮木脂素，具有抗前列腺癌 (PCA) 活性。异水飞蓟宾 A 抑制癌细胞增殖并诱导 G1 期阻滞和细胞凋亡，通过靶向Akt-NF-κB-雄激素受体 (AR) 轴激活 PCA 细胞的凋亡机制[1][2]。
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研究领域：Apoptosis
作用靶点：Apoptosis
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献：[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.
[2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.
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