Isoacteoside | 异麦角甾苷

MCE 国际站：Isoacteoside

中文名：异麦角甾苷

CAS：61303-13-7

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：Isoacteoside 是一种天然化合物，与作为阳性对照的氨基胍 (IC50=1,056 μM) 和槲皮素 (IC50=28.4 μM) 相比，IC50 值为 4.6-25.7 μM，可显着抑制晚期糖基化终产物的形成。 IC50 值：目标：在大鼠晶状体醛糖还原酶测定中，与阳性对照相比，阿克托苷、异阿克替苷和脊髓灰质苷对大鼠晶状体醛糖还原酶表现出更大的抑制作用，IC50 值分别为 0.83、0.83 和 0.85 μM，3 ,3-四亚甲基戊二酸 (IC50=4.03 μM) 和槲皮素 (IC50=7.2 μM)。

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研究领域：Others

作用靶点：Others

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参考文献：[1]. Yu SY, et al. Caffeoylated phenylpropanoid glycosides from Brandisia hancei inhibit advanced glycation end product formation and aldose reductase in vitro and vessel dilation in larval zebrafish in vivo. Planta Med. 2013 Dec;79(18):1705-9.

[2]. Gao H, Cui Y, Kang N, et al. Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization. Br J Pharmacol. 2017;174(17):2880-2896. 

[3]. Yang X, Guo F, Peng Q, Liu Y, Yang B. Suppression of in vitro and in vivo human ovarian cancer growth by isoacteoside is mediated via sub-G1 cell cycle arrest, ROS generation, and modulation of AKT/PI3K/m-TOR signalling pathway. J BUON. 2019;24(1):285-290