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MCE 国际站:Aluminum Hydroxide
中文名:氢氧化铝
CAS:21645-51-2
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:氢氧化铝是用作佐剂的铝的口服活性主要形式。基于氢氧化铝的佐剂研究包括储存库效应、促吞噬效应和促炎 NLRP3 通路的激活。氢氧化铝还可作为佐剂来补偿亚单位疫苗的低固有免疫原性[1][2]。
体内:氢氧化铝(口服;100 mg/kg/天,持续 7 天)会增加脂质过氧化并降低大脑中 SOD 的活性。氢氧化铝可溶于蒸馏水形成均匀的悬浮液[3]。
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研究领域:Others
作用靶点:Others
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参考文献:[1]. He P, et al. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccin Immunother. 2015;11(2):477-88.
[2]. Amini Y, et al. Aluminum hydroxide nanoparticles show strong activity to stimulate Th-1 immune response against tuberculosis. Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1331-1335.
[3]. Ohtawa M, et al. Effect of aluminum ingestion on lipid peroxidation in rats. Chem Pharm Bull (Tokyo). 1983 Apr;31(4):1415-8.
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