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MCE 国际站:BCI
CAS:1245792-51-1
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:BCI ((E)-BCI) 是一种 DUSP6(双重特异性磷酸酶 6)抑制剂。 BCI 显示出抗炎活性并减少活性氧 (ROS) 的产生。脑机接口可用于炎症性疾病研究[1][2]。
体外:BCI (100 ng/mL; 24 h)下调RAW264.7巨噬细胞中DUSP6的表达[2]。BCI (0-1 nM; 24 h)抑制DUSP6的表达脂多糖 (LPS) 激活的巨噬细胞中的 IL-1β 和 IL-6[2]。BCI(0-4 nM;24 小时)减少 ROS 产生并激活 Nrf2 通路LPS 激活的巨噬细胞[2]。
热销产品:Fesoterodine (fumarate) | Cefdinir | Brilliant Blue FCF | Gibberellic acid | Thiamphenicol | MTL-CEBPA | Fialuridine | Tarenflurbil | Daclatasvir | Silychristin
研究领域:Metabolic Enzyme/Protease
作用靶点:Phosphatase
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.
[2]. Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681.
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