Prednisone | 强的松

MCE 国际站：Prednisone

中文名：强的松

CAS：53-03-2

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：泼尼松 (Adasone) 是一种合成的皮质类固醇药物，作为免疫抑制剂化合物特别有效。目标：其他 泼尼松是一种合成皮质类固醇药物，作为免疫抑制药物特别有效。它用于治疗某些炎症性疾病（如中度过敏反应）和（较高剂量）某些类型的癌症，但具有显着的副作用。由于它会抑制免疫系统，因此患者更容易受到感染。泼尼松也可用于治疗失代偿性心力衰竭，以增强肾脏对利尿剂的反应性，特别是大剂量袢利尿剂对难治性利尿剂抵抗的心力衰竭患者。作用机制为泼尼松作为一种糖皮质激素，可通过增加肾髓质内集合管中A型利钠肽受体的密度，提高肾对心钠素的反应性，诱导强效利尿。

体内：Prednisone (intramuscular injection, 10 mg/kg once a day, on days 4 to 13) reduces the survival rate on days lower than the control group in BALB/c mice with encephalomyocarditis virus myocarditis. Besides, myocardial virus titers reaches a maximum on day 4, but there is no antibody titer, and on day 8 virus titers remains elevated and antibody titers is also high. On day 10, antibody titers are significantly lower than controls, while viral titers remains significantly elevated[2]. Prednisone (5 mg/kg, intragastrically administration, daily) can cause changes in FA metabolism in SLE mouse (MRL/lpr) model[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female MRL/lpr mice[3] Dosage: 5 mg/kg Administration: intragastrically administration, daily Result: Elevated polyunsaturated FA, such as arachidonic acid and docosahexaenoic acid, and reduced the total level of n-6 polyunsaturated fatty acidsin. Clinical Trial

热销产品：UNC0638  | Neridronate  | Biotin-PEG2-acid  | AZ8838  | Lurasidone  | Phorbol  | Bivatuzumab  | Glasdegib  | N-Acetyl-D-cysteine  | Marein

研究领域：Immunology/Inflammation  |  Vitamin D Related/Nuclear Receptor  |  Apoptosis

作用靶点：Glucocorticoid Receptor  |  Apoptosis

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1(4):488-96.

[2]. N Tomioka, et al. Effects of prednisolone on acute viral myocarditis in mice. J Am Coll Cardiol. 1986 Apr;7(4):868-72.

[3]. Qianqian Li, et al. Metabolic Profiling Reveals an Abnormal Pattern of Serum Fatty Acids in MRL/lpr Mice Under Treatment With Prednisone. Front Pharmacol. 2020 Feb 25;11:115.