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MCE 国际站:Azaserine
中文名:偶氮丝胺酸
CAS:115-02-6
品牌:MedChemExpress (MCE)
存储条件:-20°C, sealed storage, away from moisture
生物活性:Azazerine (CI-337) 是一种 glutamine amidotransferase 的竞争性抑制剂。 Azaserine 是一种抗生素,具有抗菌活性。 Azazerine 具有抗肿瘤活性,也可作为肿瘤诱导剂。 Azazerine可用于癌症和感染的研究[1][2][3][4][5]。
体外:Azaserine (100 μg/mL; 6 h) 引起敏感生物某些特定类型的形态变化,例如白色念珠菌细胞[2]的特征性伸长。 Azaserine (0-10 μM) 抑制 E 的生长。 UTH 4、UTH 7036、UTH 7048 和 UTH 7049 的 MIC 值为 12.11、51.9、69.2 和 69.2 μg/mL 的大肠杆菌菌株[3]。
体内:Azaserine(5 mg/kg;ip 每周一次或两次,持续 6 个月)在大鼠中诱导肿瘤[1]。
热销产品:Hyaluronidase | G15 | Pemigatinib | (S)-Mephenytoin | Proteinase K | Sulfasalazine | Aspirin | PKM2-IN-1 | Auranofin | Indomethacin
研究领域:Anti-infection | Cell Cycle/DNA Damage
作用靶点:Bacterial | Antibiotic | DNA/RNA Synthesis
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Longnecker DS, Curphey TJ. Adenocarcinoma of the pancreas in azaserine-treated rats. Cancer Res. 1975 Aug;35(8):2249-58.
[2]. Shigemichi GUNJI, et al. Screening of Antifungal Antibiotics According to Activities Inducing Morphological Abnormalities. Agric. Biol Chem., 47 (9), 2061-2069, 1983.
[3]. Williams MV, Tritz GJ. Studies on the modes of action of azaserine inhibition of Escherichia coli. Potentiation of phenylalanine reversal. J Antimicrob Chemother. 1977 Jan;3(1):65-77.
[4]. Catane R, et al. Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity. Cancer Treat Rep. 1979 Jun;63(6):1033-8. [5]. Lyons SD, et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265(19):11377-81.
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