SB-269970 (hydrochloride)

MCE 国际站：SB-269970 (hydrochloride)

CAS：261901-57-9

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：SB-269970 hydrochloride 是一种有效、选择性和脑渗透性 5-HT7 受体 拮抗剂，pK_i 为 8.3。 SB-269970 hydrochloride 对其他 5-HT 受体表现出 >50 倍的选择性^[1][2]。 IC50 和目标：pKi：8.3（5-HT7 受体）^[1] 

体内： SB269970 盐酸盐 (SB-269970A) (3- 30 mg/kg；腹腔注射；一次) 显着阻断苯丙胺和氯胺酮诱导的多动症^[2]。

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研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. http://www.ncbi.nlm.nih.gov/pubmed/10821781

[2]. Roberts C, et al. The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol. 2001 Apr;132(7):1574-80.

[3]. Monti JM, et al. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Behav Brain Res. 2008 Aug 22;191(2):184-9.