Inosine | 肌苷

MCE 国际站：Inosine

中文名：肌苷

CAS：58-63-9

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：肌苷是由腺苷分解代谢产生的内源性嘌呤核苷。肌苷具有抗炎、镇痛、免疫调节和神经保护作用。肌苷是腺苷 A₁ (A₁R) 和 A_2A (A< sub>2AR) 受体^[1][2][3]。 

体外：肌苷剂量依赖性地刺激通过 A_2AR^[2] 介导的 cAMP 产生。

肌苷剂量依赖性地诱导 hA_2AR介导的 ERK1/2 磷酸化^[2]。肌苷（100 μM；24 小时）减少用星形胶质细胞培养的 MES 23.5 细胞的氧化应激^[3]。

体内：肌苷 (10-100 mg/kg; ip) 对小鼠具有镇痛作用^[2]。

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研究领域：GPCR/G Protein  |  Metabolic Enzyme/Protease

作用靶点：Adenosine Receptor  |  Endogenous Metabolite

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参考文献：[1]. Filipe Marques Gonçalves, et al. Signaling pathways underlying the antidepressant-like effect of inosine in mice. Purinergic Signal. 2017 Jun; 13(2): 203-214.

[2]. Ajith A. Welihinda, et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun; 28(6): 552-560.

[3]. Francisney Pinto Nascimento, et al. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. 2015;51(3):1368-78.

[4]. Sara Cipriani, et al. Protection by inosine in a cellular model of Parkinson’s disease. Neuroscience. 2014 Aug 22; 274: 242-249.