(S)-Mephenytoin

国际站：(S)-Mephenytoin

CAS：70989-04-7

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：(S)-Mephenytoin ((+)-Mephenytoin) 是一种抗惊厥药。 (S)-Mephenytoin 是细胞色素 P450 (CYP) 亚型 CYP2C19 的底物。 (S)-Mephenytoin 可用于细胞色素 P450 代谢的分析^[1][2]。 

体外：在细胞色素 b5 存在的情况下，所有五种纯化的细胞色素 P-450 制剂^[1] 对 S-美芬妥英的 K_m 均为 1.25 mM。

参考文献：[1]. Shimada T, et, al. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261(2):909-21.[2]. Goldstein JA, et, al. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52.