5'-Methylthioadenosine

CAS：2457-80-9

品牌：MedChemExpress (MCE)

存储条件：-20°C, protect from light

生物活性：5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) 是多胺合成过程中由 S-腺苷甲硫氨酸 (SAM) 生成的核苷^[1]。 5'-Methylthioadenosine 通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡来抑制肿瘤，同时控制肿瘤组织的炎症微环境。 5'-甲硫腺苷及其相关物质对肿瘤发生具有显着的调控作用^[2]。 

体外：5'-甲硫腺苷对 MTAP⁺ 细胞的保护作用明显优于 MTAP⁻ 细胞免受 6TG（6'-硫鸟嘌呤）的影响毒性^[3]。

体内：2FA（2'-氟腺嘌呤）+ MTA（5'-甲硫腺苷）组合（100 mg/kg MTA；20 mg/kg 2FA）抑制四种不同MTAP^{− 小鼠异种移植模型中的人肿瘤细胞系[3].}

参考文献：[1]. Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.[2]. Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.[3]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.[4]. Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.