Acetylcholine (chloride)

国际站：Acetylcholine (chloride)

中文名：氯化乙酰胆碱

CAS：60-31-1

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture and light

生物活性：乙酰胆碱氯化物 (ACh chloride) 是一种神经递质，是一种有效的胆碱能激动剂。 Acetylcholine chloride 是一种通过刺激烟碱型乙酰胆碱受体 (nAChRs)^[1][2] 来调节多巴胺能 (DAergic) 神经元活性的调节剂。乙酰胆碱氯化物在体外抑制 p53 突变肽聚集^[5]。

体外：乙酰胆碱氯化物（ACh chloride; 10 μM）打开钙通道，在高钙培养基中荧光值和细胞内游离钙显着增加，而在无钙培养基中汗腺上皮细胞荧光值和细胞内游离钙降低 ^[3].

体内：Acetylcholine chloride（ACh chloride；SC；20 mg/kg；单剂量）在实验性感染中诱导显着的胆碱能刺激和小鼠存活率的增加^[4]。

参考文献：[1]. Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3(5): 413-420.[2]. A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9.[3]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41.[4]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2.[5]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357.