质子治疗装置研发团队成果，研发团队由中国科学院上海应用物理研究所、中国科学院上海高等研究院和上海艾普强粒子设备有限公司共同组成

Article title: SAPT: A Synchrotron-Based Proton Therapy Facility in Shanghai

文章标题：上海先进质子治疗：一台上海的基于同步加速器的质子治疗设施

DOI: 10.1007/s41365-023-01293-1

One sentence summary:

一句话概要：

Shanghai's SAPT facility heralds a new era in cancer treatment by utilizing advanced synchrotron-based proton therapy to precisely target tumors with minimized collateral damage.

上海的SAPT设施通过利用先进的基于同步加速器的质子治疗技术来精确治疗肿瘤，同时最大程度地减少了对周围组织的伤害，为癌症治疗提供了一项新选择。

Keywords:

关键词：

SAPT, proton therapy, synchrotron, slow extraction, gantry, beam delivery system

上海先进质子治疗, 质子治疗, 同步加速器, 慢引出、旋转机架、束流配送系统

The Novelty (What)  

创新性（主要内容）

A synchrotron-based proton therapy facility has been inaugurated in Shanghai, elevating the standards of cancer treatment in the region. In a clinical trial encompassing 47 patients, the research illuminated the facility's prowess: both the synchrotron and the treatment system operated at their expected peak performances. The results are promising whereby the facility's beam delivery system and other technical components consistently met the anticipated performances. With its success, Shanghai's innovative facility offers hope for enhanced therapeutic methods in cancer care and propels the  medical community toward broader applications and expansions of proton therapy.

一台基于同步加速器的质子治疗装置已在上海启用，提升了该地区癌症治疗的实力。一项47位患者的临床试验显示了该设施的能力：同步加速器和治疗系统都达到了预期的性能。设施的束流配送系统和其他系统始终满足预期的性能。凭借其成功，上海的这台装置为癌症患者提供了新的治疗方法，并推动医学界朝着质子治疗的更广泛应用迈进。

The Background (Why)

研究背景（主要原因）

Proton therapy is an advance approach to cancer treatment. It is distinguished by its utilization of the Bragg peak—a phenomenon where protons and heavy ions expel most of their energy at the end of their travel in matter. This mechanism ensures treatment of targeted tumors with minimal damage to surrounding tissues. Most proton therapy utilized accelerators like cyclotrons, which generated excessive radiation and radioactivation. Recognizing these shortcomings, the Shanghai research team introduced the synchrotron-based facility. This solution is designed to deliver the required beam energy directly.

质子治疗是一种先进的癌症治疗方法。它的特点是利用布拉格峰—— 质子和重离子在物质中的射程末端释放出大部分能量。这一机制确保目标肿瘤的治疗效果的同时对周围组织的损伤最小。很多质子治疗装置的加速器会采用回旋加速器，会产生过多的辐射和活化。为了应对这些缺点，上海的研究团队研发了基于同步加速器的装置，旨在直接提供所需能量的束流。

The SDG impact (Big Why)

SDG影响力（研究意义）

According to the World Health Organization, cancer is the second leading cause of death globally, underscoring the urgency for innovative treatments. The Shanghai advance proton therapy (SAPT) facility in Shanghai directly addresses this pressing concern, heralding a safer and more effective approach to cancer treatment. This initiative aligns seamlessly with UNSDG 3: Good Health and Well-being, by advancing global health standards. Furthermore, by fostering innovation in healthcare infrastructure, the facility embodies the principles of SDG 9: Industry, Innovation, and Infrastructure.

根据世界卫生组织的数据，癌症是全球第二大死因。这强调了寻找创新治疗方法的紧迫性。上海先进质子治疗装置（SAPT）直接应对了这一紧迫关注的问题，预示着癌症治疗更安全和更有效的方法。这一举措与联合国可持续发展目标3：健康和福祉，紧密相连。此外，通过促进医疗保健基础设施的创新，该设施体现了联合国可持续发展目标 9：工业，创新和基础设施的原则。