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过去20天,关于新型冠状病毒已经发表了50多篇论文,科学家们急于理解这一病原体以及它是怎样传播的。
新型冠状病毒,也称作2019-nCoV,导致了严重的呼吸道疾病,目前已感染并致死多人,并已扩散至多国。
Nature用新冠病毒相关关键词搜索了bioRxiv, medRxiv等学术网站,截止1月30日,至少有50篇新冠病毒英文论文发表,超过一半在过去7天发表。
超过30篇发表在预印本服务器,部分发表在同行评议期刊上,包括《柳叶刀》和《病毒学杂志》。该统计未包括中文杂志。
其中几篇论文预测了该病毒的传播速度,以及它的潜伏期。其他论文聚焦于该病毒的结构和基因构成,这一信息有助于鉴别出药物靶点和开发相关疫苗。
另外,研究人员还在GISAID、GenBank等平台公布了病毒基因组数据,不过这些未统计在内。
https://www.nature.com/articles/d41586-020-00253-8
以下为论文列表(未完全统计)
1 Offline: 2019-nCoV outbreak—early lessons
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30212-9/fulltext
2 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30211-7/fulltext#
3 Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30251-8/fulltext
4 A novel coronavirus outbreak of global health concern
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30185-9/fulltext
5 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext
6 A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30154-9/fulltext
7 Emerging understandings of 2019-nCoV
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30186-0/fulltext
8 Coronavirus Infections—More Than Just the Common Cold
https://jamanetwork.com/journals/jama/fullarticle/2759815
9 The Novel Coronavirus Originating in Wuhan, China Challenges for Global Health Governance
https://jamanetwork.com/journals/jama/fullarticle/2760500
10 Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany
https://www.nejm.org/doi/full/10.1056/NEJMc2001468?query=featured_coronavirus
11 Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam
https://www.nejm.org/doi/full/10.1056/NEJMc2001272?query=featured_coronavirus
12 Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
https://www.nejm.org/doi/full/10.1056/NEJMoa2001316?query=featured_coronavirus
13 A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment
https://www.nejm.org/doi/full/10.1056/NEJMp2000929?query=featured_coronavirus
14 A Novel Coronavirus from Patients with Pneumonia in China, 2019
https://www.nejm.org/doi/full/10.1056/NEJMoa2001017?query=featured_coronavirus
15 The psychological effects of quarantining a city
https://www.bmj.com/content/368/bmj.m313
16 Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross‐species transmission from snake to human
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25682
17 Following the evidence, from coronavirus to terrorism response
https://www.bmj.com/content/368/bmj.m344
18 The 2019‐new coronavirus epidemic: evidence for virus evolution
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25688
19 Coronavirus Infections and Immune Responses
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25685
20 Updated understanding of the outbreak of 2019 novel coronavirus (2019‐nCoV) in Wuhan, China
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25689
21 Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross‐species transmission from snake to human
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25682
22 Emerging coronaviruses: genome structure, replication, and pathogenesis
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25681
23 Outbreak of Pneumonia of Unknown Etiology in Wuhan China: the Mystery and the Miracle
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25678
24 Potential of large ‘first generation’ human‐to‐human transmission of 2019‐nCoV
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25693
25 Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS
https://jvi.asm.org/content/early/2020/01/23/JVI.00127-20
预印本
1 Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
https://www.biorxiv.org/content/10.1101/2020.01.28.923011v1
2 Origin time and epidemic dynamics of the 2019 novel coronavirus
https://www.biorxiv.org/content/10.1101/2020.01.25.919688v2
3 Transmission dynamics of 2019 novel coronavirus (2019-nCoV)
https://www.biorxiv.org/content/10.1101/2020.01.25.919787v1
4 The 2019-new coronavirus epidemic: evidence for virus evolution
https://www.biorxiv.org/content/10.1101/2020.01.24.915157v1
5 Potential inhibitors for 2019-nCoV coronavirus M protease from clinically approved medicines
https://www.biorxiv.org/content/10.1101/2020.01.29.924100v1
6 Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China
https://www.biorxiv.org/content/10.1101/2020.01.23.916726v1
7 2019-20 Wuhan coronavirus outbreak: Intense surveillance is vital for preventing sustained transmission in new locations
https://www.biorxiv.org/content/10.1101/2020.01.24.919159v1
8 Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China
https://www.biorxiv.org/content/10.1101/2020.01.24.919183v1
9 Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm
https://www.biorxiv.org/content/10.1101/2020.01.21.914044v2
10 A mathematical model for simulating the transmission of Wuhan novel Coronavirus
https://www.biorxiv.org/content/10.1101/2020.01.19.911669v1
11 Insights into Cross-species Evolution of Novel Human Coronavirus 2019-nCoV and Defining Immune Determinants for Vaccine Development
https://www.biorxiv.org/content/10.1101/2020.01.29.925867v1
12 Breaking down of healthcare system: Mathematical modelling for controlling the novel coronavirus (2019-nCoV) outbreak in Wuhan, China
https://www.biorxiv.org/content/10.1101/2020.01.27.922443v2
13 Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin
https://www.biorxiv.org/content/10.1101/2020.01.22.914952v2
14 Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China
https://www.biorxiv.org/content/10.1101/2020.01.20.913368v2
15 Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak
https://www.biorxiv.org/content/10.1101/2020.01.23.916395v2
16 Pattern of early human-to-human transmission of Wuhan 2019-nCoV
https://www.biorxiv.org/content/10.1101/2020.01.23.917351v1
17 Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening
https://www.biorxiv.org/content/10.1101/2020.01.28.922922v2
18 Beware of asymptomatic transmission: Study on 2019-nCoV prevention and control measures based on extended SEIR model
https://www.biorxiv.org/content/10.1101/2020.01.28.923169v1
19 Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation
https://www.biorxiv.org/content/10.1101/2020.01.27.921627v1
20 Risk of 2019 novel coronavirus importations throughout China prior to the Wuhan quarantine
https://www.medrxiv.org/content/10.1101/2020.01.28.20019299v1
21 Estimated effectiveness of traveller screening to prevent international spread of 2019 novel coronavirus (2019-nCoV)
https://www.medrxiv.org/content/10.1101/2020.01.28.20019224v1
22 Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions
https://www.medrxiv.org/content/10.1101/2020.01.23.20018549v2
23 Epidemiological characteristics of novel coronavirus infection: A statistical analysis of publicly available case data
https://www.medrxiv.org/content/10.1101/2020.01.26.20018754v1
24 Estimating the effective reproduction number of the 2019-nCoV in China
https://www.medrxiv.org/content/10.1101/2020.01.27.20018952v1
25 The incubation period of 2019-nCoV infections among travellers from Wuhan, China
https://www.medrxiv.org/content/10.1101/2020.01.27.20018986v2
26 Epidemiological identification of a novel infectious disease in real time: Analysis of the atypical pneumonia outbreak in Wuhan, China, 2019-20
https://www.medrxiv.org/content/10.1101/2020.01.26.20018887v1
27 Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV
28 Homology Models of Wuhan Coronavirus 3CLpro Protease
https://chemrxiv.org/articles/Homology_Models_of_Wuhan_Coronavirus_3CLpro_Protease/11637294
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