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Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs
德国马普所Asifa Akhtar大佬的Annual review of genetics综述,主要讲述果蝇剂量补偿过程及复合物各亚单元的作用,涉及表观遗传学,3D基因组学及1.688 Satellite Repeats:
Drosophila Sex Determination and X Chromosome Regulation Connected by SXL Protein
SXL Protein Precludes Dosage Compensation Initiation in Females
MSL-1 Phosphorylation Is Necessary for Its Chromosome Association
Male-Specific Expression of MSL-2 Contributes to X Chromosomal Specificity
MSL-2 Protein-Mediated Ubiquitination
MSL-3 Protein Enhances Acetylation Activity of the MSL Complex
MOF Protein Is Responsible for Histone H4 Lysine 16 Acetylation
MLE Protein Is Responsible for roX RNA Integration into the MSL Complex
roX1 AND roX2 PERFORM DOUBLE DUTY DURING DOSAGE COMPENSATION
Dynamic Stem-Loops of roX RNAs as an Interaction Platform for MLE and MSL-2 Proteins
roX Long Noncoding RNAs Are Essential for MSL Complex Spreading to Neighboring Regions
High-Affinity Sites Serve as Facilitators for Recruitment of the Dosage Compensation Complex
Distinct Features Associated with High-Affinity Sites
Satellite Repeats and X Chromosome Recognition
X Chromosome Three-Dimensional Architecture Enables Dosage Compensation
GENE EXPRESSION CONTROL OF THE X CHROMOSOME IN MALES
Global Transcription Analyses Addressing X Chromosome Regulation
Alternative Models for Male X Chromosome Dosage Compensation
及未来可以研究的问题:
论文链接:https://www.annualreviews.org/doi/full/10.1146/annurev-biochem-062917-011816#_i33
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