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Dosage Compensation of the X Chromosome

已有 1835 次阅读 2018-12-18 20:43 |个人分类:文献阅读|系统分类:论文交流| 剂量补偿;综述

Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs

德国马普所Asifa Akhtar大佬的Annual review of genetics综述,主要讲述果蝇剂量补偿过程及复合物各亚单元的作用,涉及表观遗传学,3D基因组学及1.688 Satellite Repeats:

Drosophila Sex Determination and X Chromosome Regulation Connected by SXL Protein

SXL Protein Precludes Dosage Compensation Initiation in Females

MSL-1 Phosphorylation Is Necessary for Its Chromosome Association

Male-Specific Expression of MSL-2 Contributes to X Chromosomal Specificity

MSL-2 Protein-Mediated Ubiquitination

MSL-3 Protein Enhances Acetylation Activity of the MSL Complex

MOF Protein Is Responsible for Histone H4 Lysine 16 Acetylation

MLE Protein Is Responsible for roX RNA Integration into the MSL Complex

roX1 AND roX2 PERFORM DOUBLE DUTY DURING DOSAGE COMPENSATION

Dynamic Stem-Loops of roX RNAs as an Interaction Platform for MLE and MSL-2 Proteins

roX Long Noncoding RNAs Are Essential for MSL Complex Spreading to Neighboring Regions

High-Affinity Sites Serve as Facilitators for Recruitment of the Dosage Compensation Complex

Distinct Features Associated with High-Affinity Sites

Satellite Repeats and X Chromosome Recognition

X Chromosome Three-Dimensional Architecture Enables Dosage Compensation

GENE EXPRESSION CONTROL OF THE X CHROMOSOME IN MALES

Global Transcription Analyses Addressing X Chromosome Regulation

Alternative Models for Male X Chromosome Dosage Compensation

及未来可以研究的问题:

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论文链接:https://www.annualreviews.org/doi/full/10.1146/annurev-biochem-062917-011816#_i33




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