软电离质谱学为生命科学作出了巨大贡献，诞生了蛋白质组学这个学科。田中耕一、约翰芬恩更因此获得诺贝尔奖。但其原理一直是一个未解之谜。对原理的研究，有助于实现仪器的设计，例如设计能够测定高分子量的离子源或者质谱仪，甚至是测定一亿分子量以上的蛋白质或者细胞。设计方案截图如下。文章链接见下面链接。实现仪器强国是现今国内重要的研究目的。

软电离质谱技术中气相离子在弱电场中的运动规律_液质联用（LCMS）仪器社区_仪器信息网论坛 (instrument.com.cn)

DOI：

10.26434/chemrxiv-2022-7sx1d-v3

luo jiehong. Basic principle of soft ionization mass spectrometry and development of ion source. ChemRxiv. Cambridge: Cambridge Open Engage; 2022; This content is a preprint and has not been peer-reviewed.

DOI：

10.26434/chemrxiv-2023-tdfnq

luo jiehong. Basic principle from electrospray ionization to soft ionization mass spectrometry and development of ion source:part Ⅰ. ChemRxiv. Cambridge: Cambridge Open Engage; 2023; This content is a preprint and has not been peer-reviewed.

DOI：

10.26434/chemrxiv-2022-n13d1-v8

Luo J. Basic principle from electrospray ionization to soft ionization mass spectrometry and development of ion source: part Ⅱ. ChemRxiv. Cambridge: Cambridge Open Engage; 2023; This content is a preprint and has not been peer-reviewed.