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Science Advances:创伤激活的ERF15通过氧化脂质生物合成驱动地钱再生

已有 433 次阅读 2022-8-13 23:42 |个人分类:每日摘要|系统分类:论文交流

The wound-activated ERF15 transcription factor drives Marchantia polymorpha regeneration by activating an oxylipin biosynthesis feedback loop

第一作者YUANKE LIANG

第一单位根特大学

通讯作者LIEVEN DE VEYLDER


 Abstract 

背景回顾The regenerative potential in response to wounding varies widely among species. Within the plant lineage, the liverwort Marchantia polymorpha displays an extraordinary regeneration capacity.  


提出问题However, its molecular pathways controlling the initial regeneration response are unknown. 


主要发现Here, we demonstrate that the MpERF15 transcription factor gene is instantly activated after wounding and is essential for gemmaling regeneration following tissue incision. 


结果1-ERF15与氧化脂质生物合成MpERF15 operates both upstream and downstream of the MpCOI1 oxylipin receptor by controlling the expression of oxylipin biosynthesis genes. 


结果2-氧化脂质与再生The resulting rise in the oxylipin dinor-12-oxo-phytodienoic acid (dn-OPDA) levels results in an increase in gemma cell number and apical notch organogenesis, generating highly disorganized and compact thalli.  


结论Our data pinpoint MpERF15 as a key factor activating an oxylipin biosynthesis amplification loop after wounding, which eventually results in reactivation of cell division and regeneration


结论We suggest that the genetic networks controlling oxylipin biosynthesis in response to wounding might have been reshuffled over evolution.


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 摘 要 

响应于创伤的再生潜力因物种而异。在植物中,苔类植物地钱表现出非凡的再生能力。然而,地钱中控制再生初始响应的分子途径尚不清楚。本文中,作者发现地钱转录因子MpERF15基因在创伤后立即被激活,并且对于组织切割后的芽胞再生至关重要。MpERF15通过控制氧化脂质生物合成基因的表达,来同时控制MpCOI1氧化脂质受体的上游和下游。氧化脂质dn-OPDA的水平升高会导致芽胞细胞数量的增加和顶端缺口的器官发生,产生高度无序并紧密排列的叶状体。作者的研究显示,MpERF15是创伤后激活氧化脂质生物合成放大环的关键因素,最终导致细胞分裂的重新激活以及随后的再生。因此,作者认为,控制创伤后氧化脂质生物合成的遗传网络可能已经在植物演化过程中被重新调整。


doi: https://doi.org/10.1126/sciadv.abo7737


Journal: Science Advance

Published date: August 12, 2022


Cite:
Yuanke Liang, Jefri Heyman, Yanli Xiang, Wiske Vandendriessche, Balkan Canher, Geert Goeminne, Lieven De Veylder. The wound-activated ERF15 transcription factor drives Marchantia polymorpha regeneration by activating an oxylipin biosynthesis feedback loop. Science Advances, 2022, 8(32): eabo7737. DOI: https://doi.org/10.1126/sciadv.abo7737

p.s. 通讯往期精彩链接:
PNAS:创伤诱导的生长素积累和ERF115表达协同作用于干细胞再生



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