背景回顾：Phosphorus (P) is an essential element for all organisms. Because P fertilizers are a non-renewable resource and high fixation in soils, sustainable agriculture requires researchers to improve crop P acquisition efficiency. 

结果1-GWAS鉴定CPU1：Here, we report a strong association signal at a locus of CPU1 (component of phosphorus uptake 1), from a genome-wide association study of P acquisition efficiency in a soybean core collection grown in the field. 

结果2-CPU1位点基因PHF1及其功能：A SEC12-like gene, GmPHF1, is identified as the causal gene for CPU1. GmPHF1 facilitates the ER (endoplasmic reticulum) exit of the phosphate transporter, GmPT4, to the plasma membrane of root epidermal cells. 

结果3-PHF1蛋白丰度的调控：A common SNP in an upstream open reading frame (uORF) of GmPHF1, which alters the abundance of GmPHF1 in a tissue-specific manner, contributes to P acquisition diversity in soybean. 

结论：A natural genetic variation conditions diversity in soybean P acquisition, which can be used to develop P-efficient soybean genotypes.

 摘 要 

磷对于所有生物来说都是一个必需营养元素。因为磷肥是一种不可再生在资源，并且其在土壤中极容易被固定，因此可持续农业需要研究者们提高作物的磷获取效率。本文中，作者通过对大田试验条件下大豆核心种质为材料，以磷获取效率为目标表型进行了全基因组关联分析，鉴定到了一个与磷吸收相关的基因位点，称之为CPU1。通过对该位点的进一步分析，作者发现其关键基因是一个SEC12-like基因GmPHF1。GmPHF1能够促进根表皮细胞中磷酸转运蛋白GmPT4从内质网转运至质膜。GmPHF1基因上游开放阅读框uORF的一个SNP能够以组织特异性的方式改变GmPHF1蛋白的丰度，从而作用于大豆的磷获取多样性。本文的研究报道了一个作用于大豆磷获取能力的自然遗传变异多态性位点，可用于创制高磷吸收的大豆基因型。

 廖 红