Recognition of pathogen-derived sphingolipids in Arabidopsis

第一作者：H. KATO

第一单位：日本京都大学

通讯作者：R. TERAUCHI

 Abstarct 

背景回顾：In plants, many invading microbial pathogens are recognized by cell-surface pattern recognition receptors, which induce defense responses. 

在植物中，许多入侵的微生物病原体是被植物的细胞表面模式识别受体识别的，从而诱导防御响应。

主要发现：Here, we show that the ceramide Phytophthora infestans–ceramide D (Pi-Cer D) from the plant pathogenic oomycete P. infestans triggers defense responses in Arabidopsis. 

本文中，作者发现来自植物病原性卵菌致病疫霉（Phytophthora infestans）的神经酰胺Pi-Cer D能够诱导拟南芥的防御响应。

结果-识别机制：Pi-Cer D is cleaved by an Arabidopsis apoplastic ceramidase, NEUTRAL CERAMIDASE 2 (NCER2), and the resulting 9-methyl–branched sphingoid base is recognized by a plasma membrane lectin receptor–like kinase, RESISTANT TO DFPM-INHIBITION OF ABSCISIC ACID SIGNALING 2 (RDA2). 9-Methyl–branched sphingoid base is specific to microbes and induces plant immune responses by physically interacting with RDA2. Loss of RDA2 or NCER2 function compromised Arabidopsis resistance against an oomycete pathogen. 

Pi-Cer D由拟南芥质外体神经酰胺酶NCER2切割，产生的9-甲基支链鞘氨醇基会被拟南芥中的质膜凝集素类受体激酶RDA2识别。9-甲基支链鞘氨醇基特异于微生物，并且通过与RDA2的物理相互作用诱导植物的免疫响应。RDA2或NCER2基因的功能缺失会导致拟南芥丢失对于卵菌病原体的抗性。

结论：Thus, we elucidated the recognition mechanisms of pathogen-derived lipid molecules in plants.

因此，本文的研究阐明了植物对于病原体来源的脂质分子的识别机制。

doi: https://doi.org/10.1126/science.abn0650

Journal: Science

Published date: May 19, 2022

CITE

H. Kato, K. Nemoto, M. Shimizu, A. Abe, S. Asai, N. Ishihama, S. Matsuoka, T. Daimon, M. Ojika, K. Kawakita, K. Onai, K. Shirasu, M. Yoshida, M. Ishiura, D. Takemoto, Y. Takano, R. Terauchi. Recognition of pathogen-derived sphingolipids in Arabidopsis. Science, 2022, 376(6595): 857-860. DOI: https://doi.org/10.1126/science.abn0650​