背景回顾：Plant cells can be distinguished from animal cells by their cell walls and high-turgor pressure. 

提出问题：Although changes in turgor and the stiffness of cell walls seem coordinated, we know little about the mechanism responsible for coordination. 

研究基础：Evidence has accumulated that plants, like yeast, have a dedicated cell wall integrity maintenance mechanism. It monitors the functional integrity of the wall and maintains integrity through adaptive responses induced by cell wall damage arising during growth, development, and interactions with the environment. These adaptive responses include osmosensitive induction of phytohormone production, defense responses, as well as changes in cell wall composition and structure. 

主要研究：Here, we investigate how the cell wall integrity maintenance mechanism coordinates changes in cell wall stiffness and turgor in Arabidopsis thaliana. 

结果1-干旱响应依赖于细胞壁功能完整：We show that the production of abscisic acid (ABA), the phytohormone-modulating turgor pressure, and responses to drought depend on the presence of a functional cell wall. 

结果2-THE1：We find that the cell wall integrity sensor THESEUS1 modulates mechanical properties of walls, turgor loss point, ABA biosynthesis, and ABA-controlled processes. 

结果3-RLP12：We identify RECEPTOR-LIKE PROTEIN 12 as a component of cell wall integrity maintenance–controlling, cell wall damage–induced jasmonic acid (JA) production. 

结论：We propose that THE1 is responsible for coordinating changes in turgor pressure and cell wall stiffness.

 摘 要 

植物细胞区别于动物细胞的重要特征就是细胞壁和高膨压。尽管细胞内的膨胀压力处于动态波动中，但是细胞壁的机械强度似乎是随之协调的，但我们对于这种协调还所知甚少。已有的证据表明，植物与酵母一样，存在一个专门用于细胞壁完整性维持的机制。该机制能够通过在植物生长、发育或者与环境互作过程中细胞壁损伤所诱导的适应性响应，来监测细胞壁的功能性完整，并维持细胞壁完整性。这些适应性响应包括了植物激素生成的渗透敏感诱导，防御响应，以及细胞壁组分和结构的变化。本文中，作者研究了拟南芥中细胞壁完整性维持机制如何协调细胞壁机械强度与细胞膨压的改变。作者发现能够调控膨压的植物激素ABA的生成以及对干旱的响应都依赖于一个功能性的细胞壁。作者发现细胞壁完整性感受器THESEUS1能够调控细胞壁的机械特性、膨压丢失点（turgor loss point，指的是细胞在脱水情况下，维持细胞膨压的能力，该值负得越多，说明细胞抗脱水能力越强）、ABA生物合成以及ABA控制的相关进程。作者还发现RLP12是细胞壁完整性维持控制、细胞壁损伤诱导茉莉酸生成的所需组分。作者认为THE1对于协调植物细胞膨压与细胞壁机械强度的改变是非常重要的。

 通讯作者 

** Thorsten Hamann **