An auxin-regulable oscillatory circuit drives the root clock in Arabidopsis

第一作者：Juan Perianez-Rodriguez

第一单位：西班牙植物生物技术和基因组中心

通讯作者：Miguel A. Moreno-Risueno

 Abstract 

隔年结实：In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression.

提出问题：The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown.

主要发现：We identified the key elements of the oscillator (AUXIN RESPONSE FACTOR 7, its auxin-sensitive inhibitor IAA18/POTENT, and auxin) that form a negative regulatory loop circuit in the oscillation zone.

结果1-计算模拟：Through multilevel computer modeling fitted to experimental data, we explain how gene expression oscillations coordinate with cell division and growth to create the periodic pattern of organ spacing.

结果2-重力刺激试验：Furthermore, gravistimulation experiments based on the model predictions show that external auxin stimuli can lead to entrainment of the root clock.

结论：Our work demonstrates the mechanism underlying a robust biological clock and how it can respond to external stimuli.

 通讯作者 

doi: https://doi.org/10.1126/sciadv.abd4722

Journal: Science Advance

Published date: Jan 01, 2021