主要发现：Here, we identified BIN2, a glycogen synthase kinase 3 (GSK3)-like kinase, as a molecular switch in the transition to robust growth after salt stress in Arabidopsis thaliana.

结果1-表达模式与功能鉴定：In the rapid recovery phase after salt stress, the calcium sensors SOS3 and SCaBP8 perceive a calcium signal and promote BIN2 localization to the plasma membraneto repress the salt stress response, and BIN2 inhibits SOS2 activity and enhances growth by releasing BZR1/BES1 transcriptional activity.

结果2-胁迫基因表达：The expression of stress- and brassinosteroid-responsive genes is coordinately regulated during this process.

结果3-功能突变: bin2-3bil1 and bin2-3bil2 mutants defective in BIN2 and its homologs BIL1 and BIL2, respectively, are hyposensitive to salt stress.

结论：Our study suggests that salt signaling modulates the subcellular localization and interactions of BIN2. By phosphorylating different substrates, BIN2 regulates the salt stress response and growth recovery.

Highlights

• BIN2 phosphorylates and inhibits SOS2 to negatively regulate salt stress tolerance.

• SOS3/SCaBP8 promotes BIN2 plasma membrane localization during recovery after salt stress.

• SOS3/SCaBP8-BIN2 module inhibits SOS2 activity and releases BZR1/BES1 activity.

• BIN2 maintains plant homeostasis by modulating salt stress response and growth.