||
第一作者:Niels A. Müller
第一单位:德国Thünen林木遗传研究所
通讯作者:Matthias Fladung
Abstract
背景与问题:Although hundreds of plant lineages have independently evolved dioecy (that is, separation of the sexes), the underlying genetic basis remains largely elusive.
研究结果:Here we show that diverse poplar species carry partial duplicates of the ARABIDOPSIS RESPONSE REGULATOR 17 (ARR17) orthologue in the male-specific region of the Y chromosome. These duplicates give rise to small RNAs apparently causing male-specific DNA methylation and silencing of the ARR17 gene. CRISPR–Cas9-induced mutations demonstrate that ARR17 functions as a sex switch, triggering female development when on and male development when off. Despite repeated turnover events, including a transition from the XY system to a ZW system, the sex-specific regulation of ARR17 is conserved across the poplar genus and probably beyond.
结论:Our data reveal how a single-gene-based mechanism of dioecy can enable highly dynamic sex-linked regions and contribute to maintaining recombination and integrity of sex chromosomes.
摘 要
尽管数百种植物支系独立演化出了雌雄异株,但是潜在的分子机制仍然还不清楚。本文中,作者发现不同的杨树物种在Y染色体的雄性特异性区段都含有一个ARR17基因的部分重复。这些重复拷贝产生了很多的小RNA,导致雄性特异性的DNA甲基化和ARR17基因沉默。CRISPR–Cas9介导的基因突变显示ARR17基因可以作为一个性别转换“开关”,“开”时可以诱导雌性发育,“关”时可以诱导雄性发育。尽管发生过多次的周转事件,包括从XY系统过渡到ZW系统,但是ARR17基因的性别特异性调控功能在杨属植物中十分保守,并且可能在其它植物支系中同样具有保守的功能。本文的数据揭示了单基因控制的雌雄异株分子机制如何保证高度动态的性别连锁区域,以及如何作用于性染色体重组和完整性的维持。
通讯作者
**Matthias Fladung**
个人简介:
1987年,马克斯-普朗克植物育种研究所,博士。
研究方向:林木遗传。
doi: 10.1038/s41477-020-0672-9
Journal: Nature Plants
Published: June 01, 2020
p.s. 往期植物性别决定相关研究链接:
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-10-19 21:28
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社