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科学前沿:基因剪刀 高峰 杨璐菡 韩春雨

已有 3081 次阅读 2016-8-8 10:46 |个人分类:今日热点|系统分类:观点评述


许培扬  青年科学家杨璐菡  http://blog.sciencenet.cn/blog-280034-931077.html

许培扬  韩春雨NgAgo科学研究数据资源  http://blog.sciencenet.cn/blog-280034-995137.html

       今年6月,全球25名基因研究领域的科学家联名在《科学》杂志上宣布,今年内将启动“人类基因组编写计划”,目标包括在10年内合成一个完整的人类基因组。

  “我们希望更好地了解人类基因组,并推动基因编辑和合成技术的发展。”30岁的中国学者杨璐菡对新华社记者说。她是“人类基因组编写计划”最年轻的发起人之一,目前在哈佛大学从事基因研究。

  全球最流行的“基因剪刀”是2013年兴起的CRISPR-Cas9技术,主要发明者之一是出生在石家庄的美籍华人科学家张峰。


科学家10年内合成人类基因组:"基因剪刀"能剪出"完美人类"?

http://tech.sina.com.cn/d/f/2016-08-08/doc-ifxutfpc4753332.shtml

POLICY FORUMGENOME ENGINEERING
The Genome Project-Write
Science  08 Jul 2016:
Vol. 353, Issue 6295, pp. 126-127
DOI: 10.1126/science.aaf6850

http://science.sciencemag.org/content/353/6295/126

 杨璐菡的13篇论文分布如下:

年份年份趋势图
记录数
占%
01.2016     1 7.692%
02.2015     2 15.385%
03.2014     5 38.462%
04.2013     3 23.077%
05.2012     2 15.385%
期刊期刊分区中科院期刊分区
记录数
占%
01.science     4 30.769%
02.nucleic acids res     2 15.385%
03.bioinformatics     1 7.692%
04.curr protoc mol biol     1 7.692%
05.methods mol biol     1 7.692%
06.nat biotechnol     1 7.692%
07.nat commun     1 7.692%
08.nat med     1 7.692%
09.proc natl acad sci u s a     1 7.692%
国家国家分布图
记录数
占%
01.美国     10 76.923%
02.中国大陆     1 7.692%
03.瑞典     1 7.692%
04.荷兰     1 7.692%
大陆城市境外城市
没有聚类出数据
大陆作者作者与主题词全部作者作者邮件
记录数
占%
01.Yang L     13 100.000%
02.Church GM     7 53.846%
03.Aach J     6 46.154%
04.Church G     6 46.154%
05.Mali P     5 38.462%
06.Yang JL     3 23.077%
07.Briggs AW     2 15.385%
08.Byrne S     2 15.385%
09.Chari R     2 15.385%
10.Esvelt KM     2 15.385%
查看更多
大陆机构第一作者机构合著机构境外机构
记录数
占%
01.哈佛医学院     11 84.615%
02.哈佛大学     6 46.154%
03.波士顿儿童医院     2 15.385%
04.kennedy krieger institute     1 7.692%
05.华盛顿大学     1 7.692%
06.波士顿大学     1 7.692%
07.瑞典卡罗琳斯卡医学院     1 7.692%
08.鲁尔大学     1 7.692%
09.麻省总医院     1 7.692%
主题词主题词搭配主题词与主题词
记录数
占%
01.genome, human     6 46.154%
02.induced pluripotent stem cells     5 38.462%
03.base sequence     4 30.769%
04.cell line     4 30.769%
05.gene targeting     4 30.769%
06.molecular sequence data     4 30.769%
07.genetic engineering     3 23.077%
08.hek293 cells     3 23.077%
09.cell separation     2 15.385%
10.clustered regularly interspaced short palindromic repeats     2 15.385%
11.genetic loci     2 15.385%
12.homologous recombination     2 15.385%
13.rna, guide     2 15.385%
14.sequence analysis, dna     2 15.385%
15.transcription factors     2 15.385%
16.alleles     1 7.692%
17.bacterial proteins     1 7.692%
18.barth syndrome     1 7.692%
19.cardiomyopathy, dilated     1 7.692%
20.caspase 9     1 7.692%
21.chromosomes, human, pair 19     1 7.692%
22.codon     1 7.692%
23.crispr-associated proteins     1 7.692%
24.crispr-cas systems     1 7.692%
25.data collection     1 7.692%
26.databases, genetic     1 7.692%
27.deoxyribonuclease i     1 7.692%
28.deoxyribonucleases     1 7.692%
29.deoxyribonucleases, type ii site-specific     1 7.692%
30.dna     1 7.692%
31.dna cleavage     1 7.692%
32.dna end-joining repair     1 7.692%
33.dna-binding proteins     1 7.692%
34.endogenous retroviruses     1 7.692%
35.endonucleases     1 7.692%
36.epithelial cells     1 7.692%
37.exons     1 7.692%
38.gene dosage     1 7.692%
39.genes, pol     1 7.692%
40.genes, reporter     1 7.692%
41.genes, synthetic     1 7.692%
42.genetic variation     1 7.692%
43.genomics     1 7.692%
44.high-throughput nucleotide sequencing     1 7.692%
45.individualized medicine     1 7.692%
46.inverted repeat sequences     1 7.692%
47.k562 cells     1 7.692%
48.kidney     1 7.692%
49.magnetics     1 7.692%
50.mitochondrial diseases     1 7.692%
Substance化学药中药
记录数
占%
01.rna, guide     2 15.385%
02.taz protein, human     2 15.385%
03.transcription factors     2 15.385%
04.bacterial proteins     1 7.692%
05.caspase 9     1 7.692%
06.codon     1 7.692%
07.crispr-associated proteins     1 7.692%
08.deoxyribonuclease i     1 7.692%
09.deoxyribonucleases     1 7.692%
10.deoxyribonucleases, type ii site-specific     1 7.692%
11.dna     1 7.692%
12.dna-binding proteins     1 7.692%
13.endodeoxyribonuclease foki     1 7.692%
14.endonucleases     1 7.692%
15.oligodeoxyribonucleotides     1 7.692%
16.reactive oxygen species     1 7.692%
17.rna     1 7.692%
18.trans-activators     1 7.692%
疾病症状治疗方法物种解剖食品
记录数
占%
01.心肌疾病     2 15.385%
02.心脏病     2 15.385%
03.扩张型心肌病     2 15.385%
04.barth综合症     1 7.692%
05.x连锁遗传性疾病     1 7.692%
06.代谢疾病     1 7.692%
07.先天性代谢缺陷     1 7.692%
08.先天性心脏缺损     1 7.692%
09.先天性畸形     1 7.692%
10.先天性脂质代谢缺陷     1 7.692%
11.先天性遗传性新生儿疾病和畸形     1 7.692%
12.先天性遗传性疾病     1 7.692%
13.多发性畸形     1 7.692%
14.心力衰竭     1 7.692%
15.心脏扩大     1 7.692%
16.心血管畸形     1 7.692%
17.心血管疾病     1 7.692%
18.线粒体疾病     1 7.692%
19.营养与代谢疾病     1 7.692%
科室学科
记录数
占%
01.department of genetics     9 69.231%
02.department of cardiology     2 15.385%
03.academic medical center     1 7.692%
04.beth israel deaconess medical center     1 7.692%
05.center for cardiovascular biology     1 7.692%
06.center for cardiovascular biology and institute for stem cell and regenerative medicine     1 7.692%
07.department of biomedical engineering     1 7.692%
08.department of cardiovascular physiology     1 7.692%
09.department of cell and molecular biology and medicine     1 7.692%
10.department of clinical chemistry and pediatrics     1 7.692%




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