读了李老师的博文，我采用知识发现的方法，对基因敲除狗研究的文献进行分析，发现9个知识点，是否有潜在的研究意义？供科研人员参考。

李卫红   JMCB:世界首只基因敲除狗的诞生 http://blog.sciencenet.cn/home.php?mod=space&uid=1045694&do=blog&id=929815

A-query: gene-target dogs
C-query: CRISPR/Cas9

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 18002 and can be accessed from the start page after you leave this session. There are 25 terms on the current B-list (9 are predicted to be relevant  9个相关知识点和问题), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=18002&interface=two-node

id # 18002 started Wed Oct 21 02:17:37 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: gene-target dogs Wed Oct 21 02:17:45 2015

A query = gene-target dogs started Wed Oct 21 02:17:45 2015
A query resulted in 6 titles
C_query_raw: CRISPR/Cas9 Wed Oct 21 02:18:00 2015

C: CRISPR/Cas9 547

A: gene-target dogs 6

AC: ( gene-target dogs ) AND ( CRISPR/Cas9 ) 1

C_query_raw: CRISPR/Cas9 Wed Oct 21 02:18:03 2015

C: CRISPR/Cas9 547

A: gene-target dogs 6

AC: ( gene-target dogs ) AND ( CRISPR/Cas9 ) 1

C query = CRISPR/Cas9 started Wed Oct 21 02:18:04 2015
C query resulted in 547 titles
A AND C query resulted in 1 titles
25 B-terms ready on Wed Oct 21 02:18:07 2015

B-list on Wed Oct 21 02:50:01 2015
1 targeting
2 rna
3 nematode
4 chain reaction
5 real time
6 dna
7 gene
8 genetic
9 polymerase

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=18002