GLYPHOSATE ISOPROPYLAMINE SALT CASRN: 38641-94-0 ISOPROPYLAMINE盐草甘膦

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Substance Identification:


Substance Name:GLYPHOSATE ISOPROPYLAMINE SALT ISOPROPYLAMINE盐草甘膦

CAS Registry Number:38641-94-0

Major Use:
PESTICIDES (HERBICIDES)


Data Type:
Carcinogenicity
Mutagenicity

Studies Data:


Carcinogenicity Studies:   致癌研究

Species:	Rat
Strain/Sex:	Sprague-Dawley/Male (50/Group)
Route:	Oral  口腔
Dose:	0; 2000; 8000; 20,000 ppm of 96.5% glyphosate, isopropylamine salt in diet for 24 mo; study duration 24 mo
Results:	Negative  阴性
Reference:	​

[CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY DEPARTMENT OF PESTICIDE REGULATION; SUMMARY OF TOXICOLOGY DATA FOR GLYPHOSATE, ISOPROPYLAMINE SALT (November 3, 1992)]

Species:	Rat
Strain/Sex:	Sprague-Dawley/Female (50/Group)
Route:	Oral
Dose:	0; 2000; 8000; 20,000 ppm of 96.5% glyphosate, isopropylamine salt in diet for 24 mo; study duration 24 mo
Tumor Site/ Type of Lesion:	Adrenal cortex: carcinoma (3/50 in high dose group vs 0 in all other groups)
Results:	Positive. (Department of Pesticides Regulation reviewer describes as a possible adverse effect.) 阳性
Reference:	​

[CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY DEPARTMENT OF PESTICIDE REGULATION; SUMMARY OF TOXICOLOGY DATA FOR GLYPHOSATE, ISOPROPYLAMINE SALT (November 3, 1992)]


Mutagenicity Studies:

Test System:	AMES SALMONELLA TYPHIMURIUM
Strain Indicator:	TA98
Metabolic Activation:	S-9, AROCLOR 1254
Method:	STANDARD PLATE
Dose:	180-1440 UG/PLATE
Results:	NEGATIVE  阴性
Reference:	​

[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]

Test System:	AMES SALMONELLA TYPHIMURIUM
Strain Indicator:	TA100
Metabolic Activation:	NONE
Method:	STANDARD PLATE
Dose:	180-1440 UG/PLATE
Results:	NEGATIVE 阴性
Reference:	​

[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]

Test System:	AMES SALMONELLA TYPHIMURIUM
Strain Indicator:	TA100
Metabolic Activation:	S-9, AROCLOR 1254
Method:	STANDARD PLATE
Dose:	180-1440 UG/PLATE
Results:	POSITIVE 阳性
Reference:	​

[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]

Test System:	BONE MARROW POLYCHROMATIC ERYTHROCYTES
End Point:	IN VIVO MICRONUCLEUS
Species:	MOUSE
Strain/Sex:	SWISS/MALE, FEMALE
Route:	IP 2X IN AQUEOUS SUSPENSION WITHIN 24 HR
Dose:	50.0-200.0 MG/KG
Dose Regimen:	48 HR TREATMENT
Results:	NEGATIVE 阴性
Reference:	​

[GRISOLIA,CK; A COMPARISON BETWEEN MOUSE AND FISH MICRONUCLEUS TEST USING CYCLOPHOSPHAMIDE, MITOMYCIN C AND VARIOUS PESTICIDES; MUTAT. RES. 518(2): 145-150, 2002]

Test System:	BOVINE LYMPHOCYTES
End Point:	IN VITRO MICRONUCLEUS
Metabolic Activation:	NONE
Dose:	28; 56; 140; 280; 560 UM/L (TEST MATERIAL SOLVENT: WATER)
Dose Regimen:	24 OR 48 HR CONTINUOUS TREATMENT
Results:	NEGATIVE 阴性
Reference:	​

[PIESOVA,E; THE INFLUENCE OF DIFFERENT TREATMENT LENGHT ON THE INDUCTION OF MICRONUCLEI IN BOVINE LYMPHOCYTES AFTER THE EXPOSURE OF GLYPHOSATE; FOLIA VET. 48(3):130-134, 2004]


Administrative Information:


CCRIS Record Number:6431

Last Revision Date:20110526

Update History:
Complete Update on 2011-05-26
Complete Update on 2006-02-02
Complete Update on 2005-09-01
Complete Update on 04/07/1995, 7 fields added/edited/deleted.