Low-power laser–activated endogenous latent transforming growth factor–β1 (LTGF-β1) directs resident dental stem cell differentiation to promote dentin regeneration.

CTLA-4 blockade induces T cell repertoire turnover, but high-frequency clonotypes are maintained in patients with favorable outcomes.

The cell of origin for the chronic lymphoproliferative disorder hairy cell leukemia is a long-term hematopoietic stem cell, as shown through human genetic data and murine genetic models.

Umbilical cord blood from healthy neonates with no known infectious exposure contains T cells with an effector memory–like phenotype.

Convergent science will require human diversity—individuals with different backgrounds and life experiences—to drive it forward.

Unearthing of the BRAF mutation in hematopoietic stem cells reveals an unexpected origin for a mature B cell malignancy and a new therapeutic target.

Damaging reactive oxygen species drives antibiotic-mediated killing.

Angiotensin receptor suppression in macrophages infiltrating damaged kidneys exacerbates renal fibrosis.

Alteration of the neonatal gut microbiome with antibiotics can impair neutrophil function and increase susceptibility to bacterial sepsis.

Blood from young mice counteracts age-related deterioration of learning and memory in old mice.