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中国科学家发现抑郁蛋白 国际研究文献分析
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我国科学家发现抑郁蛋白
中国科学院神经科学研究所胡海岚研究组科学家实验发现，抑郁的发生和大脑内一种名叫"βCaMKII"的蛋白分子有关，当它出现在大脑"缰核"的部位时，就会将负面情绪传递给大脑。此研究成果已在美国《科学》杂志刊登，为未来抑郁症的治疗提供了新的药物靶点。http://t.itc.cn/HY9b4
βCaMKII in lateral habenula mediates core symptoms of depression.
Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China.
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression. However, the molecular mechanism by which LHb becomes hyperactive in depression remains unknown. Through a quantitative proteomic screen, we found that expression of the β form of calcium/calmodulin-dependent protein kinase type II (βCaMΚΙΙ) was significantly up-regulated in the LHb of animal models of depression and down-regulated by antidepressants. Increasing β-, but not α-, CaMKII in the LHb strongly enhanced the synaptic efficacy and spike output of LHb neurons and was sufficient to produce profound depressive symptoms, including anhedonia and behavioral despair. Down-regulation of βCaMKII levels, blocking its activity or its target molecule the glutamate receptor GluR1 reversed the depressive symptoms. These results identify βCaMKII as a powerful regulator of LHb neuron function and a key molecular determinant of depression.
Li K. Zhou T. Liao L. Yang Z. Wong C. Henn F. Malinow R. Yates JR. Hu H.
Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China.
来源: Science ( P 0036-8075 E 1095-9203 ) IF:31.027 H指数:711 年: 2013 卷: 341 期: 6149 页: 1016-20
PMID: 23990563 [Pubmed]
本文引用地址：http://blog.sciencenet.cn/blog-280034-724922.html
上一篇：[转载]国内外科研动态 9月14日
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Top Terms | Publications | |
|---|---|---|
| Animals | 12 | |
| Calcium-Calmodulin-Dependent Protein Kinase Type 2 | 11 | |
| Calcium/calmodulin-dependent protein kinase type II alpha chain | 8 | |
| Phosphotransferases | 7 | |
| calcium- and calmodulin-dependent protein kinase complex | 7 | |
| calmodulin-dependent protein kinase activity | 7 | |
| Mice | 7 | |
| Plastics | 7 | |
| Neurons | 7 | |
| Receptors, AMPA | 6 | |
| signal transduction | 6 | |
| Synapses | 6 | |
| Synaptic Transmission | 6 | |
| Calcium-Calmodulin-Dependent Protein Kinases | 5 | |
| Receptors, N-Methyl-D-Aspartate | 5 | |
| N-methyl-D-aspartate selective glutamate receptor activity | 5 | |
| N-Methylaspartate | 5 | |
| Neuronal Plasticity | 5 | |
| Protein Kinases | 4 | |
| Proteins | 4 | |
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| Buisson A | 1 | |
| Moustié O | 1 | |
| Lemieux M | 1 | |
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| Bontempi B | 1 | |
| DeKoninck P | 1 | |
| Marc R | 1 | |
| Lin Y | 1 | |
| Jones B | 1 | |
| Liu A | 1 | |
| Tucker J | 1 | |
| Rapp K | 1 | |
| 1 2 3 4 | ||
Top Terms | Publications | |
|---|---|---|
| Animals | 12 | |
| Calcium-Calmodulin-Dependent Protein Kinase Type 2 | 11 | |
| Calcium/calmodulin-dependent protein kinase type II alpha chain | 8 | |
| Phosphotransferases | 7 | |
| calcium- and calmodulin-dependent protein kinase complex | 7 | |
| calmodulin-dependent protein kinase activity | 7 | |
| Mice | 7 | |
| Plastics | 7 | |
| Neurons | 7 | |
| Receptors, AMPA | 6 | |
| signal transduction | 6 | |
| Synapses | 6 | |
| Synaptic Transmission | 6 | |
| Calcium-Calmodulin-Dependent Protein Kinases | 5 | |
| Receptors, N-Methyl-D-Aspartate | 5 | |
| N-methyl-D-aspartate selective glutamate receptor activity | 5 | |
| N-Methylaspartate | 5 | |
| Neuronal Plasticity | 5 | |
| Protein Kinases | 4 | |
| Proteins | 4 | |
| 1 2 3 ...15 | ||
Top Years | Publications | |
|---|---|---|
| 2012 | 3 | |
| 2009 | 3 | |
| 2007 | 3 | |
| 2011 | 2 | |
| 2002 | 1 | |
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| United States | 7 | |
| Netherlands | 2 | |
| China | 1 | |
| France | 1 | |
| Italy | 1 | |
Top Cities | Publications | |
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| Stanford | 3 | |
| Rotterdam | 2 | |
| Beijing | 1 | |
| Caen | 1 | |
| Salt Lake City | 1 | |
| Houston | 1 | |
| New Orleans | 1 | |
| Augusta | 1 | |
| Napoli | 1 | |
Top Journals | Publications | |
|---|---|---|
| Neurosci Lett | 2 | |
| J Neurosci | 2 | |
| Faseb J | 1 | |
| Proc Natl Acad Sci U S A | 1 | |
| Nat Neurosci | 1 | |
| J Biol Chem | 1 | |
| Brain Res | 1 | |
| P Natl Acad Sci Usa | 1 | |
| Neuropharmacology | 1 | |
| Neuron | 1 | |
Top Authors | Publications | |
|---|---|---|
| Tsien R | 2 | |
| Thiagarajan T | 2 | |
| Yu L | 1 | |
| Liu Z | 1 | |
| Liu X | 1 | |
| Zhang J | 1 | |
| Nicole O | 1 | |
| El Gaamouch F | 1 | |
| Buisson A | 1 | |
| Moustié O | 1 | |
| Lemieux M | 1 | |
| Labrecque S | 1 | |
| Bontempi B | 1 | |
| DeKoninck P | 1 | |
| Marc R | 1 | |
| Lin Y | 1 | |
| Jones B | 1 | |
| Liu A | 1 | |
| Tucker J | 1 | |
| Rapp K | 1 | |
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