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Science：基因治疗方法研究进展国际研究信息分析报告

已有 3014 次阅读 2013-9-5 14:26 |个人分类:信息分析|系统分类:科研笔记| 国际, 治疗方法

Science：行之有效的基因治疗方法 http://www.bio360.net/news/show/6942.html

基因治疗（gene therapy）的理念非常简单——将健康基因引入到患者体内，健康基因的产物将减轻缺陷基因所引起的身体缺陷或延缓疾病的进展。但是为什么在过去的三十年里，用该方法治疗患者的临床成功案例却鲜有报道呢？其中一个主要的障碍是将基因输送到合适的细胞、组织和器官中去。

Inder M. Verma. Gene Therapy That Works. Science 23 August 2013; DOI: 10.1126/science.1242551

科学家发现30种常见癌症DNA新疗法 http://www.bioon.com/biology/cancer/581252.shtml

检索策略 gene therapy AND ("Genetic Therapy/methods"[mesh])

检索时间 2013年9月5日15时

检索结果 PUBMED数据库检索到相关文献17067篇

分析平台 http://www.pubmedplus.cn/Pubmed/Statistic

分析结果如下：

研究主题领域

01.Genetic Therapy/methods 17067 篇100.000%

02.Gene Transfer Techniques* 7909 篇46.341%

03.Genetic Vectors* 7567 篇44.337%

04.Neoplasms/therapy 5669 篇33.216%

05.Adenoviridae/genetics 2813 篇16.482%

06.Neoplasms/genetics 2480 篇14.531%

07.Genetic Vectors/genetics 2285 篇13.388%

08.Genetic Vectors/therapeutic use 1979 篇11.595%

09.Retroviridae/genetics 1713 篇10.037%

10.Transfection/methods 1122 篇6.574%

11.Genetic Therapy/trends 973 篇5.701%

12.Dependovirus/genetics 973 篇5.701%

13.DNA/genetics 824 篇4.828%

14.Lentivirus/genetics 792 篇4.641%

15.Immunotherapy/methods 779 篇4.564%

16.Transduction, Genetic/methods 762 篇4.465%

17.Thymidine Kinase/genetics 668 篇3.914%

18.Plasmids/genetics 626 篇3.668%

19.Recombinant Proteins/genetics 607 篇3.557%

20.Genetic Therapy/adverse effects 585 篇3.428%

21.RNA Interference* 569 篇3.334%

22.Glioma/therapy 521 篇3.053%

23.DNA/metabolism 505 篇2.959%

24.Brain Neoplasms/therapy 459 篇2.689%

25.Gene Targeting/methods 451 篇2.643%

26.Green Fluorescent Proteins/genetics 434 篇2.543%

27.Liver/metabolism 432 篇2.531%

28.RNA, Messenger/metabolism 425 篇2.490%

29.Liver Neoplasms/therapy 425 篇2.490%

30.RNA, Small Interfering/genetics 413 篇2.420%

31.Luciferases/genetics 388 篇2.273%

32.Drug Delivery Systems/methods 376 篇2.203%

33.Stem Cell Transplantation/methods 376 篇2.203%

34.Apoptosis/genetics 375 篇2.197%

35.Genetic Vectors/metabolism 342 篇2.004%

36.RNA, Small Interfering/therapeutic use 339 篇1.986%

37.Recombinant Fusion Proteins/genetics 333 篇1.951%

38.RNA, Messenger/genetics 323 篇1.893%

39.Promoter Regions, Genetic/genetics 261 篇1.529%

40.Green Fluorescent Proteins/metabolism 254 篇1.488%

41.Vascular Endothelial Growth Factor A/genetics 245 篇1.436%

42.Apoptosis/drug effects 245 篇1.436%

43.Carcinoma, Hepatocellular/therapy 238 篇1.395%

44.RNA, Small Interfering/metabolism 195 篇1.143%

45.Oncolytic Virotherapy/methods 184 篇1.078%

46.Nanoparticles/chemistry 170 篇

0.996

文献作者分布

1.Curiel DT 176 篇1.031%

02.Zhang Y 108 篇0.633%

03.Li J 104 篇0.609%

04.Li Y 93 篇0.545%

05.Wang J 93 篇0.545%

06.Wilson JM 90 篇0.527%

07.Zhang X 87 篇0.510%

08.Wang Y 85 篇0.498%

09.Liu Y 84 篇0.492%

10.Wang L 81 篇0.475%

11.Ylä-Herttuala S 81 篇0.475%

12.Wang X 78 篇0.457%

13.Li S 74 篇0.434%

14.Zhang L 72 篇0.422%

15.Wang H 71 篇0.416%

16.Zhang J 66 篇0.387%

17.Li X 63 篇0.369%

18.Thrasher AJ 63 篇0.369%

19.Liu X 59 篇0.346%

20.Liu J 57 篇0.334%

21.Chen J 56 篇0.328%

22.Prieto J 56 篇0.328%

23.Nakamura T 55 篇0.322%

24.Wang S 52 篇0.305%

25.Kim SW 50 篇0.293%

26.Wang W 50 篇0.293%

27.Li Q 49 篇0.287%

28.Li Z 49 篇0.287%

29.Chen X 47 篇0.275%

30.Yang J 47 篇0.275%

31.Li H 47 篇0.275%

32.Chen Y 47 篇0.275%

33.High KA 43 篇0.252%

34.Hauswirth WW 43 篇0.252%

35.Wang Z 43 篇0.252%

36.Hajjar RJ 42 篇0.246%

37.Lee M 41 篇0.240%

38.Li C 39 篇0.229%

39.Zhang Z 37 篇0.217%

40.Zhao X 37 篇0.217%

41.Waddington SN 36 篇0.211%

42.Zhou J 36 篇0.211%

43.Zhang W 36 篇0.211%

44.Yu H 36 篇0.211%

45.Wang B 35 篇0.205%

46.Zhang H 34 篇0.199%

47.Yang L 33 篇0.193%

48.Xu Y 29 篇0.170%

49.Wang P 24 篇0.141%

50.Wei YQ 24 篇

0.141研究机构分布

1.university of california 287 篇1.682%

02.university of pittsburgh 287 篇1.682%

03.university of pennsylvania 231 篇1.353%

04.inserm 225 篇1.318%

05.national institutes of health 211 篇1.236%

06.harvard medical school 206 篇1.207%

07.osaka university 188 篇1.102%

08.baylor college of medicine 171 篇1.002%

09.university of florida 164 篇0.961%

10.university of alabama at birmingham 163 篇0.955%

11.university of michigan 143 篇0.838%

12.gene therapy center 138 篇0.809%

13.university of pittsburgh school of medicine 124 篇0.727%

14.university college london 123 篇0.721%

15.massachusetts general hospital 120 篇0.703%

16.national cancer institute 110 篇0.645%

17.sichuan university 101 篇0.592%

18.university of washington 100 篇0.586%

19.mayo clinic 90 篇0.527%

20.kyushu university 90 篇0.527%

21.west china hospital 75 篇0.439%

22.johns hopkins university school of medicine 75 篇0.439%

23.tongji medical college 74 篇0.434%

24.stanford university school of medicine 74 篇0.434%

25.mount sinai school of medicine 73 篇0.428%

26.children's hospital of philadelphia 72 篇0.422%

27.kyoto university 71 篇0.416%

28.huazhong university of science and technology 68 篇0.398%

29.seoul national university 67 篇0.393%

30.university of pennsylvania school of medicine 67 篇0.393%

31.university of minnesota 66 篇0.387%

32.university of north carolina at chapel hill 62 篇0.363%

33.imperial college london 61 篇0.357%

34.university of oxford 59 篇0.346%

35.thomas jefferson university 59 篇0.346%

36.sun yat-sen university 57 篇0.334%

37.zhejiang university 51 篇0.299%

38.washington university school of medicine 51 篇0.299%

39.chinese academy of sciences 50 篇0.293%

40.fudan university 49 篇0.287%

41.tongji hospital 46 篇0.270%

42.leiden university medical center 46 篇0.270%

43.university of navarra 45 篇0.264%

44.academic medical center 45 篇0.264%

45.central south university 41 篇0.240%

46.third military medical university 39 篇0.229%

47.hannover medical school 35 篇0.205%

48.yonsei university college of medicine 28 篇0.164%

49.university of massachusetts medical school 27 篇

0.158

文献的期刊分布

1.Gene Ther 2297 篇13.459%

02.Mol Ther 683 篇4.002%

03.Hum Gene Ther 656 篇3.844%

04.Cancer Gene Ther 519 篇3.041%

05.J Gene Med 300 篇1.758%

06.Cancer Res 289 篇1.693%

07.Curr Gene Ther 254 篇1.488%

08.Blood 206 篇1.207%

09.Methods Mol Biol 169 篇0.990%

10.Nihon Rinsho 169 篇0.990%

11.Expert Opin Biol Ther 158 篇0.926%

12.Curr Opin Mol Ther 149 篇0.873%

13.Proc Natl Acad Sci U S A 147 篇0.861%

14.J Control Release 126 篇0.738%

15.Biochem Biophys Res Commun 120 篇0.703%

16.Clin Cancer Res 112 篇0.656%

17.Anticancer Res 99 篇0.580%

18.Circulation 93 篇0.545%

19.Cardiovasc Res 92 篇0.539%

20.Nat Biotechnol 92 篇0.539%

21.Adv Exp Med Biol 90 篇0.527%

22.World J Gastroenterol 86 篇0.504%

23.Biomaterials 84 篇0.492%

24.Int J Oncol 79 篇0.463%

25.Adv Drug Deliv Rev 72 篇0.422%

26.PLoS One 70 篇0.410%

27.J Virol 62 篇0.363%

28.Curr Pharm Des 59 篇0.346%

29.Zhonghua Yi Xue Za Zhi 57 篇0.334%

30.Cancer Biol Ther 57 篇0.334%

31.Oncol Rep 55 篇0.322%

32.Cancer Lett 55 篇0.322%

33.Int J Pharm 55 篇0.322%

34.Front Biosci 50 篇0.293%

35.Circ Res 50 篇0.293%

36.Pharm Res 47 篇0.275%

37.Exp Neurol 45 篇0.264%

38.J Surg Res 43 篇0.252%

39.Neurobiol Dis 39 篇0.229%

40.Expert Opin Drug Deliv 35 篇0.205%

41.Hum Mol Genet 35 篇0.205%

42.Am J Physiol Heart Circ Physiol 35 篇0.205%

43.Cancer Sci 31 篇0.182%

44.J Invest Dermatol 29 篇0.170%

45.Med Hypotheses 28 篇0.164%

46.Ther Deliv 28 篇0.164%

47.Cancer Biother Radiopharm 27 篇0.158%

48.Brain Res 27 篇0.158%

49.Mol Pharm 24 篇0.141%

50.Int J Nanomedicine 17 篇

0.100

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