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11位生命科学突破奖得主：4 荷兰皇家艺术与科学学院 H. Clevers
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| 十一位科学家获生命科学巨奖 |
据《自然》网站消息，来自美国、荷兰和日本的11位科学家获得了首届生命科学大奖——“生命科学突破奖”（Breakthrough Prize in Life Sciences）。他们分别获得该奖的五个奖项，每个得奖人将获奖金300万美元，该数目是诺贝尔奖单项奖金（2012年为120万美元）的2.5倍。
1 美国普林斯顿大学教授David Botstein
2 美国哈佛大学教授Eric S. Lander 获基因组学奖
3 美国康奈尔大学教授Lewis C. Cantley
4 荷兰皇家艺术与科学学院Hubrecht研究所教授Hans Clevers
5 美国加州大学圣地亚哥分校教授Napoleone Ferrara
6 美国纪念斯隆•凯特林癌症中心教授Charles L. Sawyers
7 美国约翰•霍普金斯大学教授Bert Vogelstein
8 美国麻省理工学院教授Robert A. Weinberg 获癌症奖
9 美国洛克菲勒大学教授Titia de Lange 获端粒奖
10 日本京都大学山中伸弥Shinya Yamanaka 获干细胞奖
11 美国洛克菲勒大学教授Cornelia I. Bargmann 获神经生物学奖
我们对每位科学家的学术成就和影响力进行分析。
4 荷兰皇家艺术与科学学院Hubrecht研究所教授Hans Clevers
| 找到的结果数: | 397 |
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| 被引频次总计: | 41107 |
| 去除自引的被引频次总计: | 38868 |
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| 施引文献: | 22259 |
| 去除自引的施引文献: | 21925 |
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| 每项平均引用次数: | 103.54 |
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| h-index : | 100 |
| Citation |
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The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how ...
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Miranda Molenaar, Marc van de Wetering, Mariette Oosterwegel, Josi Peterson-Maduro, Susan Godsave, Vladimir Korinek, Jeroen Roose, Olivier Destrée,XTcf-3 is a maternally expressed Xenopus homolog of the mammalian HMG box factors Tcf-1 and Lef-1. The N-terminus of XTcf-3 binds to β-catenin. Microinjection of XTcf-3 mRNA in embryos results in nuclear translocation of β-catenin. The β-catenin–XTcf-3 complex activates transcription in a transient reporter gene assay, while XTcf-3 ...
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Nick Barker, Johan H. van Es, Jeroen Kuipers, Pekka Kujala, Maaike van den Born, Miranda Cozijnsen, Andrea Haegebarth, Jeroen Korving, Harry Begthel, Peter J. Peters,The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently believed that four to six crypt stem cells reside at the +4 position immediately above the Paneth cells in the small intestine; colon stem cells remain undefined. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5, also known as Gpr49) was selected from ...
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The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in various differentiation events during embryonic development and leads to tumor formation when aberrantly activated. Molecular studies have pinpointed activating mutations of the Wnt signaling pathway as the cause of approximately 90% of colorectal cancer (CRC), and somewhat less frequently in cancers at other sites, such ...Journal: Biochimica Et Biophysica Acta-reviews on Cancer - BBA-REV CANCER , vol. 1653, no. 1, pp. 1-24, 2003
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Mutations of the genes encoding APC or ß-catenin in colon carcinoma induce the constitutive formation of nuclear ß-catenin/Tcf-4 complexes, resulting in activated transcription of Tcf target genes. To study the physiological role of Tcf-4 (which is encoded by the Tcf7l2 gene), we disrupted Tcf7l2 by homologous recombination. Tcf7l2 -/-mice die shortly after birth. A single ...
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Marc van de Wetering, Robert Cavallo, Dennis Dooijes, Moniek van Beest, Johan van Es, Joseph Loureiro, Arne Ypma, Deborah Hursh, Tamara Jones, Amy Bejsovec, Mark Peifer, Mark Mortinhttp://academic.research.microsoft.com/io.ashx?type=5&id=2741291&selfId1=3032394&selfId2=-1&maxNumber=12&query=The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with β-catenin and are hypothesized to mediate Wingless/Wnt signaling. We have cloned a maternally expressed Drosophila TCF family member, dTCF. dTCF binds a canonical TCF DNA motif and interacts with the β-catenin homolog Armadillo. Previous studies have identified two regions in Armadillo ...
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Journal: Science
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The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells (Citations: 356)
Marc van de Wetering, Elena Sancho, Cornelis Verweij, Wim de Lau, Irma Oving, Adam Hurlstone, Karin van der Horn, Eduard Batlle, Damien Coudreuse, Anna-Pavlina Haramis, Menno Tjon-Pon-Fong, Petra Moererhttp://academic.research.microsoft.com/io.ashx?type=5&id=3864743&selfId1=3032394&selfId2=-1&maxNumber=12&query=The transactivation of TCF target genes induced by Wnt pathway mutations constitutes the primary transforming event in colorectal cancer (CRC). We show that disruption of β-catenin/TCF-4 activity in CRC cells induces a rapid G1 arrest and blocks a genetic program that is physiologically active in the proliferative compartment of colon crypts. Coincidently, an intestinal differentiation program is ... -
Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes ...
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Eduard Batlle, Jeffrey T. Henderson, Harry Beghtel, Elena Sancho, Gerwin Huls, Jan Meeldijk, Jennifer Robertson, Marc van de Wetering, Tony Pawson,In the small intestine, the progeny of stem cells migrate in precise patterns. Absorptive, enteroendocrine, and goblet cells migrate toward the villus while Paneth cells occupy the bottom of the crypts. We show here that β-catenin and TCF inversely control the expression of the EphB2/EphB3 receptors and their ligand ephrin-B1 in colorectal cancer and along the crypt-...
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The intestinal epithelium follows the paradigms of stem cell biology established for other self-renewing tissues. With a unique topology, it constitutes a two-dimensional structure folded into valleys and hills: the proliferative crypts and the differentiated villi. Its unprecedented self-renewal rate appears reflected in a high susceptibility to malignant transformation. The molecular mechanisms that control homeostatic self-renewal ...
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Marc van de Wetering, Irma Oving, Vanesa Muncan, Menno Tjon Pon Fong, Helen Brantjes, Dik van Leenen, Frank C. P. Holstege, Thijn R. Brummelkamp, Reuven Agami,We have designed a doxycycline-regulated form of the H1 promoter of RNA polymerase III that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs). As a proof-of-principle, we have targeted β-catenin in colorectal cancer (CRC) cells. T-cell factor (TCF) target-gene expression is induced by accumulated β-catenin, and is the main ...
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Donald A. Glass, Peter Bialek, Jong Deok Ahn, Michael Starbuck, Millan S. Patel, , Mark M. Taketo, Fanxin Long, Andrew P. McMahon, Richard A. Lang, Gerard KarsentyInactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiation; inactivation of Lrp5, a gene encoding a likely Wnt coreceptor, results in low bone mass (osteopenia) by decreasing bone formation. These observations indicate that Wnt signaling controls osteoblast differentiation and suggest that it may regulate bone formation in differentiated osteoblasts. Here, we study later events and find that stabilization of ...
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Sjef Verbeek, David Izon, Frans Hofhuis, Els Robanus-Maandag, Hein Te Riele, Marc Van De Watering, Mariette Oosterwegel, Anne Wilson, H. Robson MacDonald,Two candidate genes for controlling thymocyte differentiation,T-cellfactor-1 (Tcf-1) and lymphoid enhancer-binding factor (Lef-1), encode closely related DNA-binding HMG-box proteins1,2. Their expression pattern is complex and largely overlapping during embryogenesis, yet restricted to lymphocytes postnatally3. Here we generate two independent germline mutations in Tcf-1 and find that thymocyte development in (otherwise ...
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Chronic inflammation and cancer are closely associated in the intestine. Anti-inflammatory medication reduces intestinal neoplasia, while colorectal cancer incidence is increased in ulcerative colitis. Cyclooxygenases are key to both diseases, yet the molecular basis of the association remains incompletely understood. Two recent Cell(Greten et al., 2004; Rakoff-Nahoum et al., 2004) papers illuminate roles of Toll-like receptors ...
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Nick Barker, Rachel A. Ridgway, Johan H. van Es, Marc van de Wetering, Harry Begthel, Maaike van den Born, Esther Danenberg, Alan R. Clarke, Owen J. Sansom,Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin has remained elusive. In a previously established Lgr5 (leucine-rich-repeat containing G-protein-coupled receptor 5) knockin mouse model, a tamoxifen-inducible Cre recombinase is expressed in long-lived intestinal stem cells. Here we ...
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Marco W. Schilham, Mariëtte A. Oosterwegel, Petra Moerer, Jing Ya, Piet A. J. de Boer, Marc van de Wetering, Sjef Verbeek, Wouter H. Lamers, Ada M. Kruisbeek, Ana Cumano,A STRIKING example of the relationship between regulation of transcription and phenotype is the central role of the Y-chromo-somal gene Sry in mammalian sex determination1,2. Sry is the founding member of a large family of so-called Sox genes1,3. During murine embryogenesis, the transcriptional activator Sox-4 is expressed at several sites, but in adult mice ...
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Annette F Baas, Jeroen Kuipers, Nicole N van der Wel, Eduard Batlle, Henk K Koerten, Peter J Peters,The LKB1 gene encodes a serine/threonine kinase that is mutated in the Peutz-Jeghers cancer syndrome. LKB1 is homologous to the Par-4 polarity genes in C. elegans and D. melanogaster. We have previously reported the identification and characterization of an LKB1-specific adaptor protein, STRAD, which activates LKB1 and translocates it from nucleus to cytoplasm. We have now ...
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche (Citations: 139)
Toshiro Sato, Robert G. Vries, Hugo J. Snippert, Marc van de Wetering, Nick Barker, Daniel E. Stange, Johan H. van Es, Arie Abo, Pekka Kujala, Peter J. Peters,
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have recently demonstrated the presence of about six cycling Lgr5+ stem cells at the bottoms of small-intestinal crypts. Here we describe the establishment of long-term culture conditions under which single crypts undergo multiple crypt fission events, while simultanously generating villus-like epithelial domains in ...
Journal: Nature , vol. 459, no. 7244, pp. 262-265, 2009
http://academic.research.microsoft.com/Detail?entitytype=2&searchtype=2&id=3032394&orderBy=1
https://blog.sciencenet.cn/blog-280034-664023.html
上一篇：11位生命科学突破奖得主：3 美国康奈尔大学教授 LC. Cantley
下一篇：11位生命科学突破奖得主：5 美国加州大学圣地亚哥分校N.Ferrara
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