检索策略

 

("gene therapy"[MeSH Terms] OR ("gene"[All Fields] AND "therapy"[All Fields]) OR "gene therapy"[All Fields]) AND ("heart diseases"[MeSH Terms] OR ("heart"[All Fields] AND "diseases"[All Fields]) OR "heart diseases"[All Fields] OR ("cardiac"[All Fields] AND "disease"[All Fields]) OR "cardiac disease"[All Fields])

 

 

检索分析平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/AnneOTate_summarize.cgi

 

信息分析结果

 

Topics   研究主题分布    文献量    Frq 1 Gene Therapy 1659 2 Myocardium 889 3 Myocardial Infarction 726 4 Heart Failure 708 5 Disease Models, Animal 691 6 Genetic Vectors 566 7 Gene Expression 535 8 Gene Transfer Techniques 497 9 Gene Expression Regulation 472 10 Myocardial Ischemia 443 11 Coronary Disease 428 12 RNA, Messenger 405 13 Neovascularization, Physiologic 382 14 Treatment Outcome 379 15 Polymorphism, Genetic 374 16 Genotype 369 17 Adenoviridae 350 18 Vascular Endothelial Growth Factor A 336 19 Rats, Sprague-Dawley 334 20 Heart 333

Restrict terms by semantic categories?

 

	Important words  文献中重要词汇分布	Frq
1	microrna	92
2	scn5a	105
3	cardiomyocyte	547
4	intramyocardially	39
5	gene	4864
6	cardiac	2917
7	heart	3156
8	kcnh2	31
9	myocardial	2004
10	mirna	59
11	serca2a	73
12	intramyocardial	181
13	ptpn11	24
14	therapy	3009
15	herg	84
16	myocardium	709
17	ventricular	1429
18	angiogenesis	476
19	remodeling	495
20	coronary	1454

 

	Author   论文作者分布	frq
1	Hajjar RJ	70
2	Morishita R	66
3	Koch WJ	65
4	Ogihara T	40
5	Kaneda Y	39
6	Wang J	36
7	Katus HA	35
8	Priori SG	35
9	Zhang Y	35
10	Isner JM	34
11	Losordo DW	34
12	Wu JC	32
13	Dzau VJ	31
14	Sawa Y	31
15	Zhang L	30
16	Carmeliet P	29
17	Li J	29
18	Collen D	28
19	Wang Y	27
20	Wang L	26

 

	Affiliations   研究机构分布	frq
1	USA	1275
2	Department of Medicine	376
3	Japan	344
4	Department of Cardiology	282
5	China	227
6	Boston	201
7	Germany	197
8	Division of Cardiology	171
9	Department of Internal Medicine	148
10	UK	144
11	Department of Surgery	137
12	Canada	132
13	New York	131
14	Italy	123
15	London	120
16	France	107
17	Department of Pediatrics	102
18	Department of Cardiovascular Medicine	99
19	Department of Pharmacology	91
20	Bethesda	86

 

	Journals    期刊分布	frq
1	Circulation	303
2	Cardiovasc Res	151
3	Circ Res	135
4	Gene Ther	117
5	J Am Coll Cardiol	107
6	J Mol Cell Cardiol	97
7	Am J Physiol Heart Circ Physiol	95
8	Hypertension	65
9	Mol Ther	60
10	Hum Gene Ther	59
11	Proc Natl Acad Sci U S A	51
12	Am J Cardiol	50
13	J Cardiovasc Pharmacol	50
14	Atherosclerosis	46
15	J Clin Invest	46
16	Int J Cardiol	45
17	Arterioscler Thromb Vasc Biol	42
18	Nippon Rinsho	41
19	PLoS One	41
20	Eur Heart J	39

 

	Years    论文年代分布
1	2012	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
2	2011	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
3	2010	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
4	2009	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
5	2008	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
6	2007	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
7	2006	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
8	2005	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
9	2004	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
10	2003	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
11	2002	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
12	2001	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
13	2000	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
14	1999	xxxxxxxxxxxxxxxxxxxxxxxxxx
15	1998	xxxxxxxxxxxxxxxxxxxx
16	1997	xxxxxxxxxxxxxx
17	1996	xxxxxxxxxxx
18	1995	xxxxxxxxxxxx
19	1994	xxxxxxx
20	1993	xxxxxxxxxx

 

	Topics    文献聚类	Frq
	Most recent articles	1081
1	Gene Therapy	1659
2	Myocardium	889
3	Myocardial Infarction	726
4	Heart Failure	708
5	Disease Models, Animal	691
6	Gene Expression	535
7	Gene Expression Regulation	472
8	Myocardial Ischemia	443
9	Coronary Disease	428
10	Polymorphism, Genetic	374
11	Cardiovascular Diseases	332
12	Coronary Artery Disease	288
13	Mutation	284
14	Heart Diseases	250
15	Electrocardiography	220
	Miscellaneous	801

 

 

参考文献

 

诺奖得主山中伸弥最新综述

2012年诺贝尔生理/医学奖得主山中伸弥不仅在体细胞重编程基础研究领域成果颇丰，而且也极力于这些基础研究成果在临床上的应用，近期他与另外一位学者共同发布了题为“An Emerging Strategy of Gene Therapy for Cardiac Disease”的综述文章，概况了针对心脏病治疗的一种新型基因治疗方法。