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乳腺癌遗传学科研信息分析结果

已有 4792 次阅读 2012-9-24 10:45 |个人分类:科技评价|系统分类:科研笔记| 科研, 科学家, 乳腺癌, 遗传特征

来自癌症基因组计划的科学家们近期报告了他们最新的癌症基因组研究成果，他们公布了800个乳腺癌的遗传特征，包括发现了导致乳腺癌最常见的形式的遗传原因，为新的治疗靶点提供线索，并确定乳腺癌和卵巢癌一种亚型之间的分子遗传相似性。生物通 www.ebiotrade.com

这项研究结果有助于更全面的了解每种乳腺癌亚型背后的分子机制，相关成果公布在Nature杂志上。

http://www.ebiotrade.com/newsf/2012-9/2012920170146451.htm

文献检索与信息分析平台：

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/AnneOTate_summarize.cgi?ID=154012&t=f&w=m

检索策略：

("breast neoplasms"[MeSH Terms] OR ("breast"[All Fields] AND "neoplasms"[All Fields]) OR "breast neoplasms"[All Fields] OR ("breast"[All Fields] AND "cancer"[All Fields]) OR "breast cancer"[All Fields]) AND ("genes"[MeSH Terms] OR "genes"[All Fields] OR "gene"[All Fields])

信息分析结果如下（前20名，详细数据请在信息分析平台上查看）：

	Topics 研究主题分布	Frq
1	Breast Neoplasms	13060
2	Cell Line, Tumor	5271
3	Gene Expression Regulation, Neoplastic	4677
4	Gene Expression Profiling	2335
5	RNA, Messenger	1973
6	Genetic Predisposition to Disease	1906
7	Tumor Markers, Biological	1872
8	Reverse Transcriptase Polymerase Chain Reaction	1816
9	Prognosis	1796
10	Mutation	1750
11	Immunohistochemistry	1737
12	Oligonucleotide Array Sequence Analysis	1672
13	Cell Proliferation	1663
14	Signal Transduction	1643
15	Genes, BRCA1	1601
16	Receptor, erbB-2	1503
17	Receptors, Estrogen	1407
18	Promoter Regions, Genetic	1390
19	Antineoplastic Agents	1309
20	Neoplasms	1304

	Important words 重要词汇分布	Frq
1	breast	23141
2	brca1	2791
3	her2	1965
4	brca2	1655
5	knockdown	1100
6	mb-231	1234
7	cancer	22417
8	mcf-7	2563
9	sirna	883
10	eralpha	1042
11	brca	732
12	trastuzumab	663
13	microarray	2407
14	microrna	513
15	gene	17174
16	mirna	393
17	her-2	823
18	mcf7	708
19	mda	1827
20	expression	14014

	Author 作者分布	frq
1	Wang Y	264
2	Zhang Y	251
3	Wang X	216
4	Li Y	184
5	Li J	168
6	Wang J	151
7	Liu Y	149
8	Zhang J	149
9	Liu J	144
10	Narod SA	141
11	Reis-Filho JS	132
12	Easton DF	126
13	Zhang X	122
14	Chen X	120
15	Wang L	116
16	Borresen-Dale AL	115
17	Li H	115
18	Li X	109
19	Lubinski J	108
20	Zhang L	108

	Affiliations 研究机构分布	frq
1	USA	5380
2	Department of Pathology	1205
3	China	1007
4	Houston	659
5	Department of Medicine	656
6	Japan	643
7	UK	641
8	Germany	636
9	Canada	599
10	Italy	568
11	Boston	529
12	France	519
13	Department of Surgery	509
14	New York	486
15	Department of Oncology	473
16	London	362
17	Toronto	350
18	Spain	339
19	Philadelphia	337
20	Bethesda	321

	Journals 文献的期刊分布	frq
1	Breast Cancer Res Treat	1270
2	Cancer Res	1115
3	Breast Cancer Res	619
4	Oncogene	593
5	Clin Cancer Res	541
6	PLoS One	472
7	J Biol Chem	434
8	Int J Cancer	423
9	BMC Cancer	403
10	J Clin Oncol	278
11	Br J Cancer	267
12	Int J Oncol	260
13	Proc Natl Acad Sci U S A	260
14	Cancer Epidemiol Biomarkers Prev	258
15	Oncol Rep	244
16	Anticancer Res	236
17	Cancer Lett	224
18	Carcinogenesis	215
19	Biochem Biophys Res Commun	192
20	J Natl Cancer Inst	178

	Years 文献的年代分布
1	2012	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
2	2011	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
3	2010	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
4	2009	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
5	2008	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
6	2007	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
7	2006	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
8	2005	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
9	2004	xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
10	2003	x
11	2002	x
12	2001	x
13	2000	x
14	1999	x
15	1998	x
16	1997	x
17	1993	x

	Topics 文献聚类	Frq
	Most recent articles	7530
1	Breast Neoplasms	13060
2	Cell Line, Tumor	5271
3	Gene Expression Profiling	2335
4	Mutation	1750
5	Signal Transduction	1643
6	Neoplasms	1304
7	Tumor Cells, Cultured	998
8	Gene Expression	955
9	Genotype	889
10	Gene Expression Regulation	695
11	Cell Line	639
12	BRCA1 Protein	636
13	Amino Acid Sequence	377
14	Cells, Cultured	360
15	ATP-Binding Cassette Transporters	195
	Not indexed by topic	10
	Miscellaneous	1007