博文
抗凝药利伐沙班与血栓栓塞研究的知识发现
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通用名：利伐沙班片
英文名：Rivaroxaban tablets
汉语拼音：LiFaShaBanPian
英文名：Rivaroxaban tablets
汉语拼音：LiFaShaBanPian
用于预防髋关节和膝关节置换术后患者深静脉血栓（DVT）和肺栓塞（PE）的形成。也可用于预防非瓣膜性心房纤颤患者脑卒中和非中枢神经系统性栓塞，降低冠状动脉综合症复发的风险等。
利伐沙班高度选择性和可竞争性抑制游离和结合的Xa因子以及凝血酶原活性，以剂量-依赖方式延长活化部分凝血活酶时间板(PT) 和凝血酶原时间(aPTT)。利伐沙班与磺达肝素钠/肝素的本质区别在于它不需要抗凝血酶III参与，可直接拮抗游离和结合的Xa因子。而肝素则需要有抗凝血酶III才能发挥作用，且对凝血酶原复合物中的Xa因子无效。
检索用词：
A-query: thromboembolism 血栓栓塞
C-query: Rivaroxaban 利伐沙班
C-query: Rivaroxaban 利伐沙班
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 328 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 16829 and can be accessed from the start page after you leave this session. There are 1729 terms on the current B-list (在文献中发现206个隐含知识概念，对科研选题和相关研究有参考价值 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.
To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.
Sem_filter:
Chemicals & Drugs
Viewed B-terms Wed Sep 19 20:25:43 2012
fondaparinux
C_query_raw: Rivaroxaban Wed Sep 19 20:34:59 2012
C: Rivaroxaban 674
A: pubmed_query_A 51794
AC: ( thromboembolism ) AND ( Rivaroxaban ) 328
C query = Rivaroxaban started Wed Sep 19 20:35:00 2012
C query resulted in 674 titles
A AND C query resulted in 328 titles
1729 B-terms ready on Wed Sep 19 20:35:09 2012
Chemicals & Drugs
Viewed B-terms Wed Sep 19 20:25:43 2012
fondaparinux
C_query_raw: Rivaroxaban Wed Sep 19 20:34:59 2012
C: Rivaroxaban 674
A: pubmed_query_A 51794
AC: ( thromboembolism ) AND ( Rivaroxaban ) 328
C query = Rivaroxaban started Wed Sep 19 20:35:00 2012
C query resulted in 674 titles
A AND C query resulted in 328 titles
1729 B-terms ready on Wed Sep 19 20:35:09 2012
B-list on Wed Sep 19 20:35:27 2012
1 fondaparinux
2 enoxaparin
3 direct factor xa
4 direct thrombin
5 clopidogrel
6 thromboprophylaxis
7 knee replacement
8 oral direct
9 nonvalvular atrial fibrillation
10 antiphospholipid syndrome
11 total knee arthroplasty
12 antiphospholipid
13 hip knee arthroplasty
14 generation oral
15 unfractionated heparin
16 recombinant activated
17 lupus anticoagulant
18 heparin induced thrombocytopenia
19 direct thrombin inhibitor
20 molecular weight heparin
21 weight heparin
22 nonvalvular
23 stroke prevention atrial
24 dabigatran
25 total knee replacement
26 induced thrombocytopenia
27 dvt
28 cardioembolic stroke
29 valvular atrial fibrillation
30 cardioembolic
31 prevention deep
32 or knee replacement
33 total knee
34 physician evidence based
35 activated factor vii
36 apixaban
37 patient nonvalvular atrial
38 heparin induced
39 prevention deep vein
40 knee arthroplasty
41 versus warfarin
42 anticoagulation atrial
43 stroke prevention
44 oral direct factor
45 factor xa inhibitor
46 anticoagulation atrial fibrillation
47 xa inhibitor
48 risk stroke
49 oral anticoagulation
50 oral anticoagulant
51 deep vein thrombosis
52 atrial appendage
53 ischaemic stroke
54 prothrombin complex concentrate
55 deep venous thrombosis
56 left atrial appendage
57 acute coronary syndrome
58 total hip or
59 thrombosis pulmonary
60 patient heparin induced
61 ischemic stroke
62 patient heparin
63 oral direct thrombin
64 treatment atrial
65 deep vein
66 thrombosis pulmonary embolism
67 recurrent venous
68 total hip
69 hip knee
70 deep venous
71 vein thrombosis pulmonary
72 xa
73 thrombophilia
74 factor xa
75 left atrial
76 etexilate
77 complex concentrate
78 arthroplasty a
79 acute coronary
80 inr
81 platelet glycoprotein
82 atrial fibrillation stroke
83 self management
84 patient atrial fibrillation
85 antithrombotic therapy
86 arthroplasty
87 european society cardiology
88 acute pulmonary embolism
89 guideline atrial fibrillation
90 blood thinner
91 versus enoxaparin
92 patient atrial
93 ischaemic attack
94 oral anticoagulant therapy
95 anticoagulant therapy
96 vte
97 non valvular
98 thrombosis american college
99 transient ischaemic
100 prevention deep venous
101 thromboprophylaxis major
102 prevention thromboembolic
103 hip arthroplasty
104 atrial fibrillation a
105 warfarin prevention
106 heparin thromboprophylaxis
107 thromboembolic disease
108 atrial fibrillation part
109 stroke prevention patient
110 antithrombotic therapy prevention
111 vein thrombosis
112 warfarin nonvalvular
113 warfarin patient atrial
114 weight heparin thromboprophylaxis
115 thrombolysis
116 therapy atrial fibrillation
117 warfarin nonvalvular atrial
118 therapy atrial
119 testing thrombophilia
120 warfarin atrial fibrillation
121 procoagulant
122 thrombin inhibitor
123 recombinant activated factor
124 anticoagulation clinic
125 coagulopathy
126 prevention thrombosis
127 antiplatelet
128 thromboplastin
129 atrial fibrillation
130 prevention thromboembolic disease
131 venous thrombosis
132 antithrombotic
133 unfractionated
134 perioperative management
135 anticoagulant treatment
136 thrombolysis myocardial infarction
137 non valvular atrial
138 tissue factor pathway
139 joint replacement
140 enoxaparin total
141 novel oral anticoagulant
142 anticoagulation therapy
143 anticoagulation
144 stroke transient ischaemic
145 hip
146 valvular
147 prophylaxis deep vein
148 hip or knee
149 compared warfarin
150 therapy antiphospholipid syndrome
151 fibrillation
152 knee arthroplasty a
153 warfarin
154 vitamin k antagonist
155 patient non valvular
156 prophylaxis deep
157 antithrombotic drug
158 stroke risk
159 anti xa
160 antithrombotic activity
161 stroke risk patient
162 stroke transient
163 anticoagulant thromboprophylaxis
164 pulmonary embolism
165 anti factor xa
166 acp journal club
167 dabigatran etexilate
168 symptomatic deep
169 stroke or embolism
170 heparin platelet factor
171 bleeding risk
172 anticoagulant atrial fibrillation
173 antiplatelet agent
174 platelet function
175 arthroplasty a meta
176 lower limb arthroplasty
177 emerging anticoagulant
178 anticoagulant therapy atrial
179 following major orthopedic
180 atrial fibrillation new
181 platelet aggregation
182 stroke atrial
183 or transient ischaemic
184 rate rhythm control
185 thrombin generation
186 platelet glycoprotein vi
187 prevention pulmonary embolism
188 vein thrombosis a
189 stroke patient atrial
190 pharmacokinetic pharmacodynamic
191 enoxaparin preventing
192 stroke atrial fibrillation
193 prevention atrial fibrillation
194 disease antithrombotic
195 vitamin k
196 ischaemic stroke transient
197 warfarin patient non
198 perioperative stroke
199 thromboembolic
200 alternative warfarin
201 stroke or transient
202 joint arthroplasty
203 disease antithrombotic therapy
204 antithrombotic agent
205 vte disease
206 heparin warfarin
207 hip or
208 canadian cardiovascular society
209 factor viii
210 acute deep vein
1 fondaparinux
2 enoxaparin
3 direct factor xa
4 direct thrombin
5 clopidogrel
6 thromboprophylaxis
7 knee replacement
8 oral direct
9 nonvalvular atrial fibrillation
10 antiphospholipid syndrome
11 total knee arthroplasty
12 antiphospholipid
13 hip knee arthroplasty
14 generation oral
15 unfractionated heparin
16 recombinant activated
17 lupus anticoagulant
18 heparin induced thrombocytopenia
19 direct thrombin inhibitor
20 molecular weight heparin
21 weight heparin
22 nonvalvular
23 stroke prevention atrial
24 dabigatran
25 total knee replacement
26 induced thrombocytopenia
27 dvt
28 cardioembolic stroke
29 valvular atrial fibrillation
30 cardioembolic
31 prevention deep
32 or knee replacement
33 total knee
34 physician evidence based
35 activated factor vii
36 apixaban
37 patient nonvalvular atrial
38 heparin induced
39 prevention deep vein
40 knee arthroplasty
41 versus warfarin
42 anticoagulation atrial
43 stroke prevention
44 oral direct factor
45 factor xa inhibitor
46 anticoagulation atrial fibrillation
47 xa inhibitor
48 risk stroke
49 oral anticoagulation
50 oral anticoagulant
51 deep vein thrombosis
52 atrial appendage
53 ischaemic stroke
54 prothrombin complex concentrate
55 deep venous thrombosis
56 left atrial appendage
57 acute coronary syndrome
58 total hip or
59 thrombosis pulmonary
60 patient heparin induced
61 ischemic stroke
62 patient heparin
63 oral direct thrombin
64 treatment atrial
65 deep vein
66 thrombosis pulmonary embolism
67 recurrent venous
68 total hip
69 hip knee
70 deep venous
71 vein thrombosis pulmonary
72 xa
73 thrombophilia
74 factor xa
75 left atrial
76 etexilate
77 complex concentrate
78 arthroplasty a
79 acute coronary
80 inr
81 platelet glycoprotein
82 atrial fibrillation stroke
83 self management
84 patient atrial fibrillation
85 antithrombotic therapy
86 arthroplasty
87 european society cardiology
88 acute pulmonary embolism
89 guideline atrial fibrillation
90 blood thinner
91 versus enoxaparin
92 patient atrial
93 ischaemic attack
94 oral anticoagulant therapy
95 anticoagulant therapy
96 vte
97 non valvular
98 thrombosis american college
99 transient ischaemic
100 prevention deep venous
101 thromboprophylaxis major
102 prevention thromboembolic
103 hip arthroplasty
104 atrial fibrillation a
105 warfarin prevention
106 heparin thromboprophylaxis
107 thromboembolic disease
108 atrial fibrillation part
109 stroke prevention patient
110 antithrombotic therapy prevention
111 vein thrombosis
112 warfarin nonvalvular
113 warfarin patient atrial
114 weight heparin thromboprophylaxis
115 thrombolysis
116 therapy atrial fibrillation
117 warfarin nonvalvular atrial
118 therapy atrial
119 testing thrombophilia
120 warfarin atrial fibrillation
121 procoagulant
122 thrombin inhibitor
123 recombinant activated factor
124 anticoagulation clinic
125 coagulopathy
126 prevention thrombosis
127 antiplatelet
128 thromboplastin
129 atrial fibrillation
130 prevention thromboembolic disease
131 venous thrombosis
132 antithrombotic
133 unfractionated
134 perioperative management
135 anticoagulant treatment
136 thrombolysis myocardial infarction
137 non valvular atrial
138 tissue factor pathway
139 joint replacement
140 enoxaparin total
141 novel oral anticoagulant
142 anticoagulation therapy
143 anticoagulation
144 stroke transient ischaemic
145 hip
146 valvular
147 prophylaxis deep vein
148 hip or knee
149 compared warfarin
150 therapy antiphospholipid syndrome
151 fibrillation
152 knee arthroplasty a
153 warfarin
154 vitamin k antagonist
155 patient non valvular
156 prophylaxis deep
157 antithrombotic drug
158 stroke risk
159 anti xa
160 antithrombotic activity
161 stroke risk patient
162 stroke transient
163 anticoagulant thromboprophylaxis
164 pulmonary embolism
165 anti factor xa
166 acp journal club
167 dabigatran etexilate
168 symptomatic deep
169 stroke or embolism
170 heparin platelet factor
171 bleeding risk
172 anticoagulant atrial fibrillation
173 antiplatelet agent
174 platelet function
175 arthroplasty a meta
176 lower limb arthroplasty
177 emerging anticoagulant
178 anticoagulant therapy atrial
179 following major orthopedic
180 atrial fibrillation new
181 platelet aggregation
182 stroke atrial
183 or transient ischaemic
184 rate rhythm control
185 thrombin generation
186 platelet glycoprotein vi
187 prevention pulmonary embolism
188 vein thrombosis a
189 stroke patient atrial
190 pharmacokinetic pharmacodynamic
191 enoxaparin preventing
192 stroke atrial fibrillation
193 prevention atrial fibrillation
194 disease antithrombotic
195 vitamin k
196 ischaemic stroke transient
197 warfarin patient non
198 perioperative stroke
199 thromboembolic
200 alternative warfarin
201 stroke or transient
202 joint arthroplasty
203 disease antithrombotic therapy
204 antithrombotic agent
205 vte disease
206 heparin warfarin
207 hip or
208 canadian cardiovascular society
209 factor viii
210 acute deep vein
研究论文计量分析结果如下：
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