科学 Science
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Science 被引用最多的10篇文献
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发文总量 Publications: 194,447
被引总量 Citation Count: 3,644,441 (自引总量 Self-Citation: 8530)
H-指数 H-Index: 598
出版年限 Year Range: 1880-2011
出版年限 Year Range: 1880-2011
学科归属 Interests: 综合学科 Multidisciplinary
被引用最多的10篇文献：
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perfectly. Put another way, there is no atechnical solutiono to the problem. I can win only by giving a radical meaning to the word awin. o I can hit my opponent over the head; or I can drug him; or I can falsify the records. Every way in which I awino involves, in some sense, an aban-donment of the ...
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Molecular classification of cancer: {C}lass discovery and class prediction by gene expression monitoring (Citations: 4500)
Todd R. Golub, Donna K. Slonim, Pablo Tamayo, C. Huard, M. Gaasenbeek, Jill P. Mesirov, H. Coller, Mignon L. Loh, James R. Downing, M. A. Caligiuri, C. D. Bloomfield, Eric S. LanderAlthough cancer classiÞcation has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery)or for assigning tumors to known classes (class prediction). Here, a generic approach to cancer classiÞcation based on gene expression monitoring by DNA microarrays is described and applied to human acute leukemias as a test case.A ... -
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J. Craig Venter, Mark D. Adams, Eugene W. Myers, Peter W. Li, Richard J. Mural, Granger G. Sutton, Hamilton O. Smith, Mark Yandell, Cheryl A. Evans, Robert A. Holt, Jeannine D. Gocayne, Peter Amanatideshttp://academic.research.microsoft.com/io.ashx?type=5&id=1291649&selfId1=-1&selfId2=-1&maxNumber=12&query=A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made ...
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Systems as diverse as genetic networks or the world wide web are best described as networks with complex topology. A common property of many large networks is that the vertex connectivities follow a scale-free power-law distribution. This feature is found to be a consequence of the two generic mechanisms that networks expand continuously by the addition of new ...
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A high-capacity system was developed to monitor the expression of many genes in parallel. Microarrays prepared by high-speed robotic printing of complementary DNAs on glass were used for quantitative expression measurements of the corresponding genes. Because of the small format and high density of the arrays, hybridization volumes of 2 microliters could be used that enabled detection of ...
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https://blog.sciencenet.cn/blog-280034-589050.html
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