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生长激素受体缺陷与癌症和糖尿病的理论知识发现

已有 7467 次阅读 2011-12-17 05:05 |个人分类:知识发现|系统分类:科研笔记| 知识, class, border, 糖尿病, 生长激素

  拜读了张彦斌博友的博文,做了知识发现,供大家参考。
 
生长激素受体有缺陷的人,虽然个子长不高,但一辈子不会得癌症和糖尿病!
 
知识发现平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature
A-query: Growth hormone receptor deficiency
C-query: cancer and diabetes
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 26 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 16949 and can be accessed from the start page after you leave this session. There are 1411 terms on the current B-list (发现有关生长激素受体缺陷与癌症和糖尿病的理论知识概念347个,对相关科研有参考意义 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=16949

AC: ( Growth hormone receptor deficiency ) AND ( cancer and diabetes ) 26

C query = cancer and diabetes started Fri Dec 16 14:41:01 2011
C query resulted in 23593 titles
A AND C query resulted in 26 titles
4996 B-terms ready on Fri Dec 16 14:43:51 2011

Sem_filter:
Concepts & Ideas
1411 B-terms left after filter executed Fri Dec 16 14:48:24 2011

B-list on Fri Dec 16 14:52:53 2011
1 ghrelin level
2 igf binding
3 androgen deprivation
4 insulin insulin growth
5 recombinant human growth
6 igf system
7 transducer activator transcription
8 growth factor system
9 proliferator activated receptor
10 gh deficiency effect
11 signal transducer activator
12 expression insulin growth
13 novel mutation
14 effect gh replacement
15 vascular endothelial growth
16 insulin release
17 growth hormone therapy
18 androgen deprivation therapy
19 glycemic control
20 25-hydroxyvitamin d
21 cardiovascular risk
22 deprivation therapy prostate
23 growth factor binding
24 i igf binding
25 cooperative growth study
26 hormone refractory prostate
27 national cooperative growth
28 suprasellar
29 insulin sensitivity
30 hormone insulin growth
31 suppressor cytokine
32 refractory prostate cancer
33 gh insulin growth
34 ins-1 cell
35 cag repeat
36 ins-1
37 expression insulin
38 releasing hormone receptor
39 growth hormone replacement
40 signaling pancreatic beta
41 gh responsiveness
42 i insulin growth
43 repeat polymorphism
44 splice site mutation
45 small cell lung
46 regulation insulin growth
47 deprivation therapy
48 hypoxia inducible
49 hepatoma cell line
50 hypothalamic pituitary
51 tamoxifen therapy
52 ppargamma activation
53 insulin binding
54 hypothalamic hamartoma
55 expression leptin
56 hypothalamic neuropeptide y
57 growth hormone secretion
58 splice site
59 genome wide
60 ret ptc1
61 insulin sensitivity beta
62 genetically engineered mouse
63 p450 oxidoreductase deficiency
64 chronic kidney
65 advanced prostate cancer
66 igf igf binding
67 treatment cushing
68 early stage prostate
69 serum insulin growth
70 hypoxia inducible factor
71 g protein alpha
72 nf kappab
73 beta cell function
74 channel insulin
75 expression igf i-induced
76 euthyroid
77 receptor insulin growth
78 treatment growth hormone
79 defect insulin
80 beta cell replication
81 treatment cushing disease
82 mammary stem cell
83 activation phosphatidylinositol 3-kinase
84 volumetric bone
85 circulating insulin growth
86 familial isolated
87 splice variant
88 factor igf binding
89 signaling pancreatic
90 vitamin d metabolism
91 role insulin growth
92 systematic review meta
93 expression leptin receptor
94 index growth hormone
95 small cell
96 human insulin growth
97 expression profile
98 insulin action
99 leptin action
100 effect gh
101 factor signaling
102 defect insulin receptor
103 quality life
104 mammary epithelial cell
105 treatment growth
106 treatment insulin
107 treatment pituitary adenoma
108 inhibit growth breast
109 effect insulin growth
110 oral glucose
111 cloning expression
112 estrogen postmenopausal
113 sensitivity beta cell
114 response gh replacement
115 beta cell
116 advanced prostate
117 pancreatic cancer cell
118 hormone binding
119 pituitary adrenal
120 neuroendocrine differentiation
121 erbb-3 expression
122 protein alpha subunit
123 dmba induced mammary
124 bone mineral density
125 receptor variant
126 c elegans
127 gastric inhibitory
128 signaling aging
129 risk marker
130 polycystic
131 liver specific
132 increase insulin
133 somatomedin level
134 mouse model thyroid
135 katp channel
136 binding thyroid hormone
137 transgenic growth
138 review meta analysis
139 c ebpbeta
140 hormone receptor expression
141 cell cycle arrest
142 stimulate beta cell
143 expression growth
144 increase adipose
145 leptin expression
146 expression nitric oxide
147 endometrial
148 increased insulin
149 overexpression
150 responsive element
151 obstructive sleep
152 regulation growth hormone
153 isolated growth hormone
154 adipose differentiation
155 insulin growth
156 hormone treatment
157 ret
158 effect growth hormone
159 treated insulin growth
160 growth hormone release
161 meta analysis
162 abnormal growth hormone
163 long term estrogen
164 prostate cancer progression
165 calorie restriction
166 expression rat
167 expression thyroid hormone
168 mammary adenocarcinoma
169 model thyroid
170 leptin regulation
171 gestational
172 treatment pituitary
173 therapy prostate cancer
174 treatment gh
175 increased insulin sensitivity
176 igf1 level
177 lifespan
178 binding protein growth
179 large cohort
180 precocious
181 necrosis factor alpha
182 systolic
183 downstream akt
184 androgen deprivation increase
185 hormone deficiency effect
186 estrogen deficiency
187 fibroblast growth
188 hormone growth
189 hormone beta receptor
190 melatonin deficiency
191 translation initiation
192 effect insulin
193 inhibit growth
194 cause pituitary
195 kindred
196 beta cell specific
197 activation protein kinase
198 vitamin d endocrine
199 full length
200 mouse model
201 human growth
202 regulation growth
203 term effect insulin
204 stage renal disease
205 increased cardiovascular risk
206 cancer cell line
207 endometrial cancer cell
208 islet beta cell
209 insulin release pancreatic
210 adrenocortical function
211 serum concentration insulin
212 role growth
213 expression prostate cancer
214 therapy insulin
215 expression peroxisome proliferator
216 postmenopausal
217 co activator
218 young overweight
219 level insulin sensitivity
220 interleukin-6 expression
221 ovarian response
222 null mice
223 early gene expression
224 c src
225 modulation igf
226 caloric restriction
227 expression thyroid
228 sex hormone binding
229 lipoprotein metabolism
230 growth prostate cancer
231 acth release
232 cardiovascular
233 severe insulin
234 therapy breast cancer
235 calorie
236 intrauterine growth
237 radiotherapy
238 ovarian germ cell
239 pituitary cell line
240 hormone binding globulin
241 disruption steroid
242 chinese
243 highly conserved
244 regulation peroxisome proliferator
245 binding growth
246 linear growth
247 advanced
248 molecular weight adiponectin
249 total high molecular
250 model thyroid cancer
251 ppargamma activation a
252 translational perspective
253 growth factor alpha
254 growth factor beta
255 longevity
256 end stage renal
257 p450 expression
258 function anterior pituitary
259 severe insulin resistance
260 receptor modulator
261 ligand binding
262 endothelial function
263 treatment osteoporosis
264 complex genetic
265 nuclear ribonucleoprotein
266 i expression
267 deficiency acromegaly
268 level gh
269 acromegaly induced
270 syndrome severe insulin
271 allogeneic bone marrow
272 intravenous dexamethasone
273 diabetes model
274 mrna expression
275 cancer treatment
276 therapy breast
277 ribonucleic acid expression
278 targeted disruption
279 modulation estrogen receptor
280 adrenal
281 transgenic mouse model
282 ablation thyroid
283 effect octreotide
284 pancreatic
285 oxygen species
286 growth response
287 multiple hormone
288 effect thyroid
289 suppressor
290 hypothalamic
291 releasing hormone analog
292 novel therapeutic
293 effect thyroid hormone
294 ca2 channel
295 expression pituitary
296 colony stimulating
297 voltage dependent
298 growth puberty
299 growth breast cancer
300 insulin responsiveness
301 nuclear localization
302 cell cycle progression
303 dose growth hormone
304 human endometrial
305 adult onset
306 high throughput
307 i level
308 growth study
309 density young
310 increased cardiovascular
311 nodular
312 growth factor level
313 estrogen deprivation
314 successful treatment cushing
315 gonadal
316 localization prolactin
317 glucose deprivation
318 length polymorphism
319 induced expression
320 adrenal response
321 ovarian
322 growth breast
323 risk factor
324 thyroid hormone beta
325 cell growth differentiation
326 thyroid hormone action
327 reactive oxygen
328 cancer growth
329 mammary carcinoma growth
330 treatment breast cancer
331 expression neuronal
332 systematic review
333 gonadotropin treatment
334 modulation glucose
335 signaling cause
336 level insulin
337 severe growth
338 binding globulin
339 mammary tumorigenesis
340 protein expression
341 premature ovarian
342 role fibroblast growth
343 ectopic
344 lesson mouse model
345 ureteral
346 hgh level
347 liver growth

 

参考文献

 

癌症研究的一个简单且重大的进展

http://blog.sciencenet.cn/home.php?mod=space&uid=590130&do=blog&id=519240

 
 


https://blog.sciencenet.cn/blog-280034-519242.html

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