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剑蛋白酶研究的信息分析与化学知识发现

已有 2390 次阅读 2011-3-24 16:29 |个人分类:信息分析|系统分类:论文交流| 蛋白酶, 调节器

美研究发现剑蛋白酶对调节细胞运动至关重要
      剑蛋白可以描述为微管调节器,它能够调节细胞运动的速度和方向。临床药物可通过抑制剑蛋白来刺激细胞向某一特定方向迁移,进而达到治病效果,剑蛋白或可刺激剑蛋白的药物可能会在治疗和预防癌症转移等方面具有重要价值。
 
Enzyme Can Steer Cells or Possibly Stop Them in Their Tracks

http://www.sciencedaily.com/releases/2011/03/110318091019.htm

信息分析平台  http://www.gopubmed.org/web/gopubmed/2?WEB1mOWEB10O00d000j10020001000h00100090000

Top Terms
Publications
Microtubules
107
microtubule-severing ATPase activity
106
katanin complex
106
Proteins
96
Adenosine Triphosphatases
96
microtubule
83
Animals
80
microtubule severing
45
Humans
37
Mutation
36
Genes
31
Tubulin
31
Amino Acid Sequence
29
Mitosis
28
Neurons
26
Microtubule-Associated Proteins
26
Genome polyprotein
24
Caenorhabditis elegans
24
Repressible acid phosphatase
22
Tumor necrosis factor receptor superfamily member 1A
22
1 2 3 ...75 

信息分析报告  Katanin.docx

知识发现平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

Start A-Literature C-Literature B-list Filter Literature
A-query: katanin
C-query: cell motility
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 11 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 30760 and can be accessed from the start page after you leave this session. There are 87 terms on the current B-list (33 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 30760 started Thu Mar 24 03:55:33 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
30760 Search ARROWSMITH A
A_query_raw: kataninThu Mar 24 03:57:10 2011

A query = katanin started Thu Mar 24 03:57:11 2011
A query resulted in 128 titles
30760 Search ARROWSMITH C
C_query_raw: cell motility Thu Mar 24 03:57:21 2011

C: cell motility 130376

A: pubmed_query_A 128

AC: ( katanin ) AND ( cell motility ) 11

C query = cell motility started Thu Mar 24 03:57:22 2011
C query resulted in 50000 titles
A AND C query resulted in 11 titles
682 B-terms ready on Thu Mar 24 04:00:33 2011

Sem_filter:
Chemicals & Drugs
87 B-terms left after filter executed Thu Mar 24 04:03:00 2011

新知识概念发现结果

B-list on Thu Mar 24 04:03:45 2011
1 microtubule associated protein
2 e3 ligase
3 ubiquitin ligase
4 ubiquitination
5 gamma tubulin complex
6 cytoplasmic dynein
7 dynein
8 gamma tubulin
9 ligas
10 ubiquitin
11 ubiquitin ligas
12 kinase required
13 meiotic spindle
14 protein phosphatase
15 related kinase
16 aaa atpase
17 beta tubulin
18 alpha tubulin
19 gibberellin signaling
20 cdna
21 protein regulate
22 adaptor
23 ligase
24 protein a novel
25 cellulose microfibril
26 fibroblast growth factor
27 aaa
28 tubulin
29 drosophila myosin
30 igf-1
31 protein involved
32 protein kinase
33 myosin


相关研究课题

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature
AB literature

B-term

BC literature

katanin microtubule associated protein cell motility
1: Tobacco microtubule-associated protein, MAP65-1c, bundles and stabilizes microtubules. 2010
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2: Microtubule-associated proteins in higher plants. 2007
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3: Interactions of tobacco microtubule-associated protein MAP65-1b with microtubules. 2004
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4: Plant microtubule-associated proteins: the HEAT is off in temperature-sensitive mor1. 2001
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1: Modulation of microtubule dynamics by the microtubule-associated protein 1a. 2009
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2: Microtubule-associated protein AtMPB2C plays a role in organization of cortical microtubules, stomata patterning, and tobamovirus infectivity. 2009
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3: Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. 2009
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4: The Fibroblast Growth Factor Receptor Substrate 3 (Frs3) Adapter is a Developmentally Regulated Microtubule-Associated Protein Expressed in Migrating and Differentiated Neurons. 2009
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5: Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: a novel biological function of MAP2 in non-neuronal cells. 2008
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6: Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination. 2008
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7: Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein. 2007
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8: Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability. 2007
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9: The microtubule-associated protein doublecortin is broadly expressed in the telencephalon of adult canaries. 2007
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10: The spindle midzone microtubule-associated proteins Ase1p and Cin8p affect the number and orientation of astral microtubules in Saccharomyces cerevisiae. 2007
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11: [Localization of microtubule-associated protein AtMAP65-1 in guard cells of arabidopsis] 2007
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12: Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. 2007
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13: MPB2C, a microtubule-associated protein, regulates non-cell-autonomy of the homeodomain protein KNOTTED1. 2007
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14: Tobacco mosaic virus movement protein functions as a structural microtubule-associated protein. 2006
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15: Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration. 2005
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16: High molecular weight microtubule-associated protein 2 over-expression in neuronal migration disorders caused by N-methyl-D-aspartate receptor activation in hamsters. 2004
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17: Microtubule-associated proteins and their essential roles during mitosis. 2004
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