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疟原虫与生物钟的研究动态与基因知识发现

已有 5119 次阅读 2011-1-10 10:44 |个人分类:知识发现|系统分类:论文交流| 知识发现, 生物钟, 疟原虫

《皇家学会学报B》:疟原虫也怕“时差”

http://news.sciencenet.cn/htmlnews/2011/1/242580.shtm

长途旅行带来的时差会让人不舒服,而英国一项最新研究发现,导致疟疾的疟原虫也怕“时差”,在与其生物钟不同的实验鼠体内,疟原虫的致病性下降了约一半。这项发现将有助于研发防治疟疾的新方法。

Malaria parasites synch with host

http://www.the-scientist.com/news/display/57905/

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

Start A-Literature C-Literature B-list Filter Literature
  A-query: Plasmodium
C-query: circadian rhythms
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 50 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 13713 and can be accessed from the start page after you leave this session. There are 1287 terms on the current B-list (493 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

job id # 13713 started Sun Jan 9 22:08:16 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
13713 Search ARROWSMITH A
A_query_raw: PlasmodiumSun Jan 9 22:08:53 2011

A query = Plasmodium started Sun Jan 9 22:08:54 2011
A query resulted in 37741 titles
13713 Search ARROWSMITH C
C_query_raw: circadian rhythms Sun Jan 9 22:09:02 2011

C: circadian rhythms 59571

A: pubmed_query_A 37741

AC: ( Plasmodium ) AND ( circadian rhythms ) 50

C query = circadian rhythms started Sun Jan 9 22:09:03 2011
C query resulted in 50000 titles
A AND C query resulted in 50 titles
20943 B-terms ready on Sun Jan 9 22:16:24 2011

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1287 B-terms left after filter executed Sun Jan 9 22:23:47 2011

B-list on Sun Jan 9 22:24:46 2011
1 toll receptor
2 hepcidin
3 single nucleotide polymorphism
4 quantitative trait loci
5 adiponectin
6 casein kinase
7 cdna library
8 transporter gene
9 aquaporin
10 cyp2c19
11 pcc
12 gene family
13 genome wide
14 c fos
15 quantitative trait locus
16 leptin
17 akt
18 mosquito net
19 petri net
20 histone deacetylase
21 rna binding protein
22 gene encoding
23 cd8
24 chromatin remodeling
25 histone acetyltransferase
26 sirtuin
27 rosette
28 cyclin dependent kinase
29 tandem repeat
30 ck2
31 phytochrome
32 synthetase gene
33 cd81
34 signal regulated kinase
35 e selectin
36 map kinase
37 cytokine production
38 thioredoxin
39 cd40 ligand
40 toll
41 allelic variant
42 allelic variation
43 reductase gene
44 ifn gamma
45 cyp2a5
46 thrombomodulin
47 leptin receptor
48 rna binding
49 polymorphism promoter
50 thymidylate synthase
51 rnai
52 chemokine
53 snp
54 helicase
55 gene expressed
56 plastid gene
57 cd1d
58 p selectin
59 ryanodine receptor
60 cd4
61 intercellular adhesion molecule
62 cloning genomic
63 regulon
64 g6pd
65 glutathione reductase
66 isph
67 signal regulated
68 reporter gene
69 oxide synthase gene
70 intron
71 oscillator
72 gene promoter
73 c jun n
74 c jun
75 luciferase
76 ppargamma
77 inos
78 transcription factor
79 hyperinsulinemia
80 th1
81 cdna
82 qtc
83 aquaporin gene
84 protease gene
85 early gene
86 ifn
87 dnak
88 open reading frame
89 serine hydroxymethyltransferase
90 retrotransposon
91 na h exchanger
92 gene transcript
93 ornithine decarboxylase
94 alpha tubulin
95 neuropeptide
96 acyl carrier protein
97 jnk
98 pup
99 reading frame
100 rop1
101 pcr
102 ornithine aminotransferase
103 heat shock protein
104 tnf
105 perforin
106 tyrosine aminotransferase
107 cgmp
108 operon
109 leucine zipper protein
110 fos
111 5-ht2
112 related gene
113 transgene
114 cytokine
115 candidate gene
116 ck1
117 gene encode a
118 il-18
119 ppar
120 protein gene
121 promoter analysis
122 vegf
123 gene belonging
124 dbp
125 l fabp
126 novel gene
127 exon
128 cloning gene
129 allele specific
130 seizure frequency
131 nf kappa b
132 cyclophilin
133 glucose-6-phosphate dehydrogenase
134 topoisomerase i
135 il-12
136 reca
137 elk-1
138 untranslated region
139 codon
140 guanylyl cyclase
141 s6
142 annexin
143 aminolevulinate synthase gene
144 platelet activation
145 tumor necrosis factor
146 nk1
147 il-6
148 apurinic apyrimidinic endonuclease
149 post transcriptional gene
150 il-10
151 fsh
152 gene encode
153 allele
154 thioredoxin reductase
155 nf kappab
156 proteinuria
157 high mobility group
158 analysis gene
159 blood glucose level
160 apolipoprotein e
161 transferrin receptor
162 endothelin
163 expression gene
164 ppar gamma
165 tetraspanin
166 topoisomerase
167 acetyltransferase
168 resistance gene
169 mdr2
170 allelic
171 clock
172 cd34
173 glycogen synthase
174 gene cluster
175 transcobalamin
176 apoptosis related gene
177 hsp90
178 drosophila melanogaster gene
179 binding protein gene
180 sms
181 rna helicase
182 o glcnac
183 adp ribosylation factor
184 ubiquitin
185 monooxygenase
186 rna polymerase i
187 il-2
188 box
189 promoter region
190 cd36
191 transporter
192 gene ontology
193 mdr1a
194 promoter activity
195 dna binding protein
196 polymorphism gene
197 cip1
198 heme oxygenase
199 hbs
200 responsive gene
201 gata
202 gsk-3
203 il-1
204 5-ht
205 th2
206 myod
207 interferon gamma
208 opiate receptor
209 db
210 structure gene
211 phosphoenolpyruvate carboxylase
212 na h antiporter
213 degenerate
214 pcna
215 genomic
216 core promoter
217 fk506
218 nucleoside phosphorylase
219 l selectin
220 protein sequence
221 5ht1a
222 cystatin
223 obese
224 lymphocyte proliferation
225 rest
226 lecithin cholesterol acyltransferase
227 sri
228 g-6-pd
229 cytochrome p-450
230 hsp70
231 s adenosylmethionine decarboxylase
232 hdl
233 acetyl coa carboxylase
234 calmodulin
235 timp
236 c3d
237 gene associated
238 diabetes mellitus
239 dam
240 matrix metalloproteinase
241 cba
242 peroxidase gene
243 erythropoietin
244 bee
245 nk
246 kelch
247 lc
248 p-450
249 gene involved
250 clone
251 mali
252 g csf
253 ferredoxin
254 3a4
255 macrophage activation
256 glyoxalase
257 tyrosine kinase
258 cyclin
259 tag
260 transcriptional control gene
261 cell cycle progression
262 masking
263 vitellogenin
264 nuclear localization signal
265 enhancer
266 gene transgenic
267 subunit gene
268 site promoter
269 retinoic acid receptor
270 rna polymerase
271 bp
272 diabetes
273 alpha gene
274 protein phosphatase
275 gene not
276 beta tubulin
277 interleukin
278 genome
279 promoter control
280 gene variant
281 gene homolog
282 calcium binding protein
283 dynamin
284 dark
285 cd36 gene
286 tnf alpha
287 protein kinase c
288 chloride channel
289 tubulin
290 von willebrand factor
291 chaperone
292 lp
293 heme
294 asia
295 polyubiquitin
296 trh
297 pp1
298 sos
299 untranslated
300 jun
301 prolactin
302 nnos
303 histone h4
304 nadp
305 p38
306 cell adhesion molecule
307 trna
308 body weight
309 actin binding
310 rrna
311 gm csf
312 trait
313 atpase gene
314 gene homologue
315 tropic
316 gsk3
317 coiled coil
318 thrombopoietin
319 malate dehydrogenase
320 raptor
321 cdna a
322 gtpase
323 glutathione peroxidase
324 pa
325 domain
326 il-1beta
327 jet
328 calcium channel
329 drb
330 c1q
331 il-3
332 glutathione s transferase
333 golden
334 protein-1 gene
335 gmp
336 h atpase
337 nude
338 aminopeptidase
339 nod
340 troponin
341 cs
342 psba
343 mhc
344 homodimer
345 immunoregulatory
346 human genome
347 sulfotransferase
348 blind
349 ldh
350 analysis promoter
351 egf
352 epilepsy
353 novel allele
354 peroxisome
355 dna binding
356 interferon gamma receptor
357 desert
358 aminotransferase
359 sir
360 leaf
361 n methyltransferase
362 hepatocyte growth factor
363 jar
364 coat
365 protease
366 mg2
367 regulated promoter
368 somatostatin
369 factor gene
370 thymidine kinase
371 immune response
372 prey
373 protein phosphatase 2a
374 proteoglycan
375 glyceraldehyde-3-phosphate dehydrogenase
376 acyltransferase
377 ribosomal protein
378 defensin
379 potassium channel
380 adenylate cyclase
381 gene transcribed
382 p glycoprotein
383 fatty acid biosynthesis
384 hsp60
385 tcdd
386 endonuclease
387 interferon alpha
388 receptor gene
389 lipoprotein lipase
390 fabp
391 alcohol dehydrogenase
392 insulin
393 hrp
394 hmg coa reductase
395 prl
396 gene relation
397 axis
398 uchl1
399 associated protein
400 laminin
401 pge2
402 erk
403 nadph
404 t7
405 pyrophosphatase
406 kinase protein
407 hypertension
408 cytochrome p450
409 gaba
410 endopeptidase
411 cd54
412 nadh
413 il-1 alpha
414 cre
415 hen
416 obesity
417 rt
418 13c
419 hla
420 platelet count
421 esi
422 ferrochelatase
423 isomerase
424 jaundice
425 fibronectin
426 adenylate kinase
427 sera
428 dba
429 nuclear protein
430 lizard
431 acs1
432 g1
433 spp
434 tgf beta1
435 metallothionein
436 gene cell
437 tnfalpha
438 intronic
439 new gene
440 epidermal growth factor
441 map
442 sp
443 gaba a
444 tgf beta
445 rain
446 monoamine oxidase a
447 p450
448 kinase gene
449 gene related
450 adenosine deaminase
451 pka
452 cho
453 integrin
454 epo
455 hn
456 dehydrogenase
457 carbonic anhydrase
458 promoter gene
459 copy
460 polypeptide
461 succinate dehydrogenase
462 igm
463 iga
464 isocitrate dehydrogenase
465 p16
466 growth hormone
467 bat
468 lacking
469 mri
470 ige
471 gene human
472 gamma glutamylcysteine synthetase
473 phosphoprotein
474 gene a
475 reductase
476 cyp
477 coa reductase gene
478 decarboxylase
479 igg
480 var
481 nf
482 aav
483 stearoyl coa desaturase
484 tof
485 acth
486 receptor kinase
487 hole
488 dip
489 asthma
490 urinary protein
491 cytochrome c
492 protein kinase
493 bright

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

 

 

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

Plasmodium gene family circadian rhythms
1: Differential Expansion of the Merozoite Surface Protein (msp)-7 Gene Family in Plasmodium species under a Birth-and-Death Model of Evolution. 2010
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2: [Var gene family and antigen variation in Plasmodium falciparum] 2010
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3: Babesia bovis expresses Bbo-6cys-E, a member of a novel gene family that is homologous to the 6-cys family of Plasmodium. 2010
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4: Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum. 2009
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5: A conserved multi-gene family induces cross-reactive antibodies effective in defense against Plasmodium falciparum. 2009
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6: Transcriptional memory and switching in the Plasmodium falciparumrif gene family. 2009
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7: Clonally variant gene families in Plasmodium falciparum share a common activation factor. 2009
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8: Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species. 2009
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9: Absence of erythrocyte sequestration and lack of multicopy gene family expression in Plasmodium falciparum from a splenectomized malaria patient. 2009
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10: The Gram-negative bacteria-binding protein gene family: its role in the innate immune system of anopheles gambiae and in anti-Plasmodium defence. 2008
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11: PlasmoGF: an integrated system for comparative genomics and phylogenetic analysis of Plasmodium gene families. 2008
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12: Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum. 2008
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13: [Regulation mechanism of variation in Plasmodium falciparum var gene family] 2007
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14: A member of the py235 gene family of Plasmodium yoelii encodes an erythrocyte binding protein recognised by a protective monoclonal antibody. 2006
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15: Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum. 2006
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16: Contrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene family. 2006
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17: Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. 2006
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18: Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes. 2006
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19: Extense variant gene family repertoire overlap in Western Amazon Plasmodium falciparum isolates. 2006
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20: Differences in the copy number of the py235 gene family in virulent and avirulent lines of Plasmodium yoelii. 2006
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21: Identification of a subtelomeric gene family expressed during the asexual-sexual stage transition in Plasmodium falciparum. 2005
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22: The annexin gene family in the malaria mosquito Anopheles gambiae. 2005
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23: Rapid evolution of an erythrocyte invasion gene family: the Plasmodium reichenowi Reticulocyte Binding Like (RBL) genes. 2004
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24: A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. 2004
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25: The MB2 gene family of Plasmodium species has a unique combination of S1 and GTP-binding domains. 2004
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26: The serine repeat antigen (SERA) gene family phylogeny in Plasmodium: the impact of GC content and reconciliation of gene and species trees. 2004
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27: A gene-family encoding small exported proteins is conserved across Plasmodium genus. 2003
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28: The 3D7var5.2 (var COMMON) type var gene family is commonly expressed in non-placental Plasmodium falciparum malaria. 2003
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29: etramps, a new Plasmodium falciparum gene family coding for developmentally regulated and highly charged membrane proteins located at the parasite-host cell interface. 2003
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30: Expansion of the receptor-like kinase/Pelle gene family and receptor-like proteins in Arabidopsis. 2003
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31: Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family. 2003
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32: Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. 2002
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33: A large gene family for putative variant antigens shared by human and rodent malaria parasites. 2002
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34: Immunity-related genes and gene families in Anopheles gambiae. 2002
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35: Plasmodium vivax merozoite surface proteins-3beta and-3gamma share structural similarities with P. vivax merozoite surface protein-3alpha and define a new gene family. 2001
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36: [Plasmodium falciparum erythocyte membrane protein 1 (PfEMP1) and gene family var] 2001
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37: Malaria: a new gene family (clag) involved in adhesion. 2000
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38: A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum. 1999
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39: Chromosomal organisation of a gene family encoding rhoptry proteins in Plasmodium yoelii. 1999
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40: The cytoadherence linked asexual gene family of Plasmodium falciparum: are there roles other than cytoadherence? 1999
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41: Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum-infected erythrocyte are encoded by the rif gene family and are the target of human immune responses. 1999
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42: Helper T-cell epitopes encoded by the Babesia bigemina rap-1 gene family in the constant and variant domains are conserved among parasite strains. 1998
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43: stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. 1998
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44: The chromosomal organization of the Plasmodium falciparum var gene family is conserved. 1997
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45: Compartmentalization of genes coding for immunodominant antigens to fragile chromosome ends leads to dispersed subtelomeric gene families and rapid gene evolution in Plasmodium falciparum. 1996
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46: Cloning and sequence analysis of a novel member of the ATP-binding cassette (ABC) protein gene family from Plasmodium falciparum. 1996
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47: The ATP-binding cassette (ABC) gene family of Plasmodium falciparum. 1996
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48: The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. 1995
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49: Isolation of a third member of the Plasmodium falciparum glycophorin-binding protein gene family. 1994
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50: Dimorphism and intergenic recombination within the microneme protein (MP-1) gene family of Plasmodium knowlesi. 1994
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51: Neutralization-sensitive merozoite surface antigens of Babesia bovis encoded by members of a polymorphic gene family. 1992
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52: Regions of an Eimeria tenella antigen contain sequences which are conserved in circumsporozoite proteins from Plasmodium spp. and which are related to the thrombospondin gene family. 1990
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1: Evolution of AANAT: expansion of the gene family in the cephalochordate amphioxus. 2010
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2: The miRNA-192/194 cluster regulates the Period gene family and the circadian clock. 2009
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3: The plant WNK gene family and regulation of flowering time in Arabidopsis. 2008
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4: Conservation, convergence, and divergence of light-responsive, circadian-regulated, and tissue-specific expression patterns during evolution of the Arabidopsis GATA gene family. 2007
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5: The zebrafish retinoid-related orphan receptor (ror) gene family. 2007
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6: The mammalian Crx genes are highly divergent representatives of the Otx5 gene family, a gnathostome orthology class of orthodenticle-related homeogenes involved in the differentiation of retinal photoreceptors and circadian entrainment. 2003
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7: Long-term microclimatic stress causes rapid adaptive radiation of kaiABC clock gene family in a cyanobacterium, Nostoc linckia, from"Evolution Canyons"I and II, Israel. 2002
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8: Analysis of the diurnal expression patterns of the tomato chlorophyll a/b binding protein genes. Influence of light and characterization of the gene family. 1990
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