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我国国产宫颈癌疫苗的研究意义重大 国际研究文献分析
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我国首个国产宫颈癌疫苗启动临床试验
http://news.sciencenet.cn/htmlnews/2011/1/242478.shtm
人体里生长的肿瘤中，目前能明确病因的只有宫颈癌。2008年的医学诺贝尔奖获得者就是证实了人乳头瘤病毒（HPV）与宫颈癌的关系。人乳头瘤病毒感染是诱发宫颈癌前病变、子宫颈癌及其他生殖器病变的一个主要因素。其中HPV16型和18型被确认为致癌基因型，可导致85.5%的子宫颈癌。HPV6型和11型感染则可导致90%以上生殖器疣。
宫颈癌疫苗项目于2002年启动。在长达八年的时间里，研究人员成功突破了国外的专利壁垒，利用自主研发的技术体系成功解决了疫苗研制的关键技术难题，在国内外申请了6项发明专利，并显著降低了疫苗的生产成本。
世界上首支宫颈癌疫苗在美国诞生，至今售价高达400美元/人。全球宫颈癌病人每年新发大约46万人，中国患者占到四分之一。因此，该疫苗一旦获准上市将为广大发展中国家妇女带来“福音”。
| 主题词： | |
| 宫颈肿瘤 | |
| 英文名称： | |
| Uterine Cervical Neoplasms | |
| 款目词： | |
| Cervical Neoplasm, Uterine; Cervical Neoplasms, Uterine; Neoplasm, Uterine Cervical; Neoplasms, Uterine Cervical; Uterine Cervical Neoplasm; Neoplasms, Cervix; Cervix Neoplasms(宫颈肿瘤); Cervix Neoplasm; Neoplasm, Cervix; Cervical Neoplasms; Cervical Neoplasm; Neoplasm, Cervical; Neoplasms, Cervical; Cancer of Cervix(子宫颈癌); Cancer of the Cervix; Uterine Cervical Cancer; Cancer, Uterine Cervical; Cancers, Uterine Cervical; Cervical Cancer, Uterine; Cervical Cancers, Uterine; Uterine Cervical Cancers; Cervix Cancer; Cancer, Cervix; Cancers, Cervix | |
| 树状结构号： | |
| C04.588.945.418.948.850; C13.351.500.852.593.131; C13.351.500.852.762.850; C13.351.937.418.875.850 | |
| 相关参见： | |
| Uterine Cervical Dysplasia(宫颈非典型增生); Cervical Intraepithelial Neoplasia(宫颈上皮内瘤样病变) | |
| 标引注释： | |
| coordinate IM with histologic type of neoplasm (IM) | |
| 历史注释： | |
| 2006 (1963) | |
| 主题词详解： | |
| Tumors or cancer of the UTERINE CERVIX. | |
| 主题词： | |
| 癌症疫苗 | |
| 英文名称： | |
| Cancer Vaccines | |
| 款目词： | |
| Vaccines, Cancer(疫苗, 癌症); Neoplasm Vaccines(肿瘤疫苗); Vaccines, Neoplasm(疫苗, 肿瘤); Tumor Vaccines(抗癌疫苗); Vaccines, Tumor(疫苗, 癌症) | |
| 树状结构号： | |
| D20.215.894.200 | |
| 化学登记号/酶代码： | |
| 0 | |
| 标引注释： | |
| coord IM with specific cancer histol type (IM) + organ/neopl precoord (IM) | |
| 标引回溯注释： | |
| Vaccines(疫苗) (1971-1996) | |
| 历史注释： | |
| 97 | |
| 主题词详解： | |
| Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced. | |
树形结构1
癌症疫苗
国际研究文献分析结果：
http://www.gopubmed.org/web/gopubmed/1?WEB01cqknictx00dgI1mI2rI00h001000j100200010
Uterine Cervical Cancer Vaccines
1,835 documents semantically analyzed
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| India |
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| Barcelona |
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| Montreal |
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| New York City |
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| Seattle |
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| Melbourne |
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| Lyon |
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| Cambridge |
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| Philadelphia |
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| Heidelberg |
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| Chapel Hill |
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| Hong Kong, Hong Kong |
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| Manchester, United Kingdom |
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Top Journals
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| Vaccine |
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129 |
| Gynecol Oncol |
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44 |
| Sex Health |
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32 |
| Int J Cancer |
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32 |
| Lancet |
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| J Natl Cancer Inst |
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| N Engl J Med |
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| Int J Gynecol Cancer |
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| Bmj |
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| Cancer |
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| J Adolesc Health |
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| Cmaj |
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| Lakartidningen |
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| Salud Publica Mex |
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| Ned Tijdschr Geneeskd |
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| J Womens Health (larchmt) |
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14 |
| Obstet Gynecol |
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13 |
| Expert Rev Vaccines |
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13 |
| Lancet Oncol |
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| J Gynecol Obstet Biol Reprod (paris) |
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| Uterine Cervical Neoplasms |
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1,773 |
| Humans |
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1,742 |
| Vaccination |
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1,605 |
| Vaccines |
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1,596 |
| Papillomavirus Vaccines |
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1,412 |
| Uterine Cervicitis |
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1,318 |
| Papillomavirus Infections |
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1,307 |
| Women |
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654 |
| Adolescent |
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622 |
| Adult |
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| Papillomaviridae |
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| Human papillomavirus 16 |
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| Immunization |
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| Immunity |
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| Viral Vaccines |
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| Viruses |
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| Child |
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| Cervical Intraepithelial Neoplasia |
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| Incidence |
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| Cancer Vaccines |
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Top Authors
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| Franco E |
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| Bosch F |
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| Wu T |
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| Schiller J |
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| Munoz N |
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| Frazer I |
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| Lehtinen M |
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| Kaufmann A |
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| Kast W |
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| Stanley M |
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| Gissmann L |
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| Harper D |
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| Schiffman M |
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| Wheeler C |
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| Paavonen J |
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| Villa L |
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| Meijer C |
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| Lowy D |
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| De Sanjosé S |
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| Roden R |
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