免疫》：中美学者发现炎症发生新机制

http://news.sciencenet.cn/htmlnews/2010/12/242171.shtm

Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and In Vivo Infiltration

http://www.cell.com/immunity/abstract/S1074-7613(10)00320-1#aff2

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

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A-query: Neutrophils and innate immunity C-query: acute inflammatory The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 275 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 8593 and can be accessed from the start page after you leave this session. There are 4069 terms on the current B-list (2107 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 8593 started Thu Dec 30 01:18:58 2010
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8593 Search ARROWSMITH A
A_query_raw: Neutrophils and innate immunityThu Dec 30 01:20:29 2010

A query = Neutrophils and innate immunity started Thu Dec 30 01:20:29 2010
A query resulted in 11232 titles
8593 Search ARROWSMITH C
C_query_raw: acute inflammatory Thu Dec 30 01:20:51 2010

C: acute inflammatory 48586

A: pubmed_query_A 11232

AC: ( Neutrophils and innate immunity ) AND ( acute inflammatory ) 275

C query = acute inflammatory started Thu Dec 30 01:20:52 2010
C query resulted in 48586 titles
A AND C query resulted in 275 titles
21155 B-terms ready on Thu Dec 30 01:26:45 2010

Sem_filter:
Chemicals & Drugs
4069 B-terms left after filter executed Thu Dec 30 01:42:03 2010

B-list on Thu Dec 30 01:44:26 2010
1 p38 mitogen activated
2 p38 mitogen
3 cox-2
4 toll receptor
5 clarithromycin
6 th1 th2 cytokine
7 surfactant protein a
8 toll receptor signaling
9 th2 cytokine
10 suppressor cytokine
11 role toll receptor
12 p38 mapk
13 sulbactam
14 cytokine induced neutrophil
15 cytokine gene expression
16 azithromycin
17 formyl peptide
18 formyl peptide receptor
19 anca
20 induced neutrophil chemoattractant
21 lipopolysaccharide binding protein
22 calprotectin
23 permeability increasing protein
24 neutrophil chemoattractant
25 proinflammatory cytokine
26 collectin
27 inflammatory cytokine
28 p38 map kinase
29 bactericidal permeability increasing
30 surfactant protein
31 toll receptor tlr
32 nimesulide
33 expression toll receptor
34 toll receptor mediated
35 anti inflammatory cytokine
36 il-18
37 lipoxin
38 highly active antiretroviral
39 mapk
40 mitogen activated protein
41 signal regulated kinase
42 interleukin-1 receptor
43 protease activated receptor
44 cytokine gene
45 neutrophil defensin
46 peroxisome proliferator activated
47 proliferator activated receptor
48 enhancer binding protein
49 benoxaprofen
50 myeloid differentiation factor
51 defensin
52 cox-2 inhibitor
53 beta defensin
54 p selectin
55 lactide
56 cefoxitin
57 alpha il-6
58 il-1 receptor
59 c5a receptor
60 interleukin-8 receptor
61 aspirin triggered
62 peroxynitrite
63 piroxicam
64 cytokine mrna
65 cefdinir
66 lipopolysaccharide binding
67 nbt
68 pylori lipopolysaccharide
69 helicobacter pylori lipopolysaccharide
70 cytokine chemokine
71 lipoxin a4
72 il-12
73 toll receptor-4
74 surfactant protein d
75 ampicillin sulbactam
76 il-8 tnf
77 antimicrobial peptide
78 role lipopolysaccharide binding
79 role surfactant protein
80 ciprofloxacin
81 azurocidin
82 cytosolic phospholipase
83 inducible nitric oxide
84 hla b27
85 cationic protein
86 elastase alpha
87 tnf receptor
88 chemotactic peptide
89 ppargamma
90 neutrophil oxidative
91 nbt test
92 mannose binding lectin
93 recombinant human erythropoietin
94 calcium pyrophosphate
95 tnf alpha il-6
96 pro anti inflammatory
97 difficile toxin
98 cytokine release
99 lactide co glycolide
100 interleukin-12
101 il-23
102 il-8 tnf alpha
103 gabexate mesilate
104 cytokine human
105 cefodizime
106 clostridium difficile toxin
107 endothelial adhesion molecule
108 imipenem
109 mannose binding
110 chemokine receptor
111 bisphosphonate
112 gammadelta t
113 ketoprofen
114 amlodipine
115 myeloperoxidase hydrogen peroxide
116 galectin-3
117 factor alpha interleukin-6
118 enrofloxacin
119 il-8
120 il-1 receptor antagonist
121 release proinflammatory cytokine
122 il-1 beta
123 cytokine production
124 cytokine acute phase
125 monocyte chemoattractant protein-1
126 release leukotriene
127 chemoattractant protein-1
128 regulation chemokine
129 a2a receptor
130 meropenem
131 nadph oxidase
132 sulfasalazine
133 beta2 integrin
134 alpha interleukin-6
135 tramadol
136 il-10
137 icam-1
138 etodolac
139 increasing protein bpi
140 beta integrin
141 il-6 tnf alpha
142 cathepsin g
143 nf kappa b
144 aspirin triggered lipoxin
145 gabexate
146 ofloxacin
147 neutrophil superoxide
148 sulfonic acid induced
149 e selectin
150 auranofin
151 cd40 ligand
152 pyrogen
153 adhesion molecule-1
154 interleukin-18
155 antiphospholipid
156 vitronectin receptor
157 gelsolin
158 protease activated
159 mac-1 cd11b cd18
160 clavulanic acid
161 cystatin c
162 chemoattractant receptor
163 cytokine induced
164 antineutrophil
165 macrophage inflammatory protein-2
166 murine colitis
167 cytokine signaling
168 chemokine gene
169 interleukin-17
170 smoke induced pulmonary
171 interleukin-13
172 bleomycin induced lung
173 expression chemokine
174 map kinase
175 annexin
176 effect cytokine
177 tran retinoic acid
178 selectin
179 il-6 tnf
180 poly lactide co
181 chemokine
182 murine model colitis
183 il-12 production
184 murine macrophage
185 mapk pathway
186 leukocyte elastase
187 chemotactic factor
188 endogenous pyrogen
189 galectin
190 cd8 t
191 roxithromycin
192 activated receptor-2
193 nuclear factor kappab
194 macrophage cytokine
195 proinflammatory cytokine production
196 elastase alpha 1-proteinase
197 ambroxol
198 selectin glycoprotein
199 oxygen radical production
200 smoke induced emphysema
201 5-lipoxygenase
202 p selectin glycoprotein
203 leukotriene b4
204 chemokine gene expression
205 cefaclor
206 cytokine response
207 pulmonary surfactant
208 cxc chemokine
209 phosphatidylinositol 3-kinase
210 neutrophil derived serine
211 interleukin-8
212 antigen induced arthritis
213 moxalactam
214 fc receptor
215 pirprofen
216 factor alpha interleukin-1
217 cytokine acute
218 ligand-1
219 osteopontin
220 cefoperazone
221 antioxidant enzyme
222 omeprazole
223 cytokine production human
224 suppressor cytokine signaling
225 il-4
226 uropathogenic
227 serum amyloid
228 il-1beta
229 t helper
230 lipoxygenase product
231 interleukin-10
232 acetaminophen induced
233 zidovudine
234 kinase p38
235 intercellular adhesion molecule-1
236 induced cytokine
237 myeloid related protein
238 n-3 fatty acid
239 paf acether
240 piperacillin
241 neutrophil activating protein
242 il-6
243 monocyte chemoattractant
244 nitric oxide synthesis
245 paf receptor
246 terminal kinase
247 nitric oxide synthase
248 oxygen free radical
249 receptor associated kinase
250 antioxidant enzyme activity
251 interleukin-6 interleukin-8
252 selectin glycoprotein ligand-1
253 granzyme
254 cytosolic phospholipase a2
255 selectin expression
256 peroxisome proliferator
257 cigarette smoke induced
258 activated protein kinase
259 gadolinium
260 lysosomal enzyme release
261 il-8 production
262 il-17-producing
263 neutrophil elastase
264 pulmonary surfactant protein
265 cyclooxygenase
266 il-1
267 mac-1
268 anandamide
269 fc gamma riii
270 lipocalin
271 inflammatory cytokine production
272 interleukin-1beta
273 dismutase glutathione peroxidase
274 tolmetin
275 flunixin
276 muramyl dipeptide
277 il-8 il-10
278 interleukin-6 tumor necrosis
279 troglitazone
280 nadph oxidase neutrophil
281 receptor expressed myeloid
282 metalloproteinase-9
283 ribavirin
284 receptor toll receptor
285 superoxide dismutase glutathione
286 derived free radical
287 urate calcium pyrophosphate
288 interleukin-1 beta
289 galectin-1
290 new quinolone
291 effect macrolide
292 csf neutrophil
293 ebola
294 role leukotriene
295 macrophage inflammatory protein
296 cytokine profile
297 neutrophil oxygen
298 matrix metalloproteinase-9
299 lipooligosaccharide
300 diclofenac
301 elafin
302 susceptibility ozone induced
303 mcp-1
304 carvedilol
305 nitro l-arginine methyl
306 l selectin
307 neutrophil chemoattractant cinc
308 igg fc receptor
309 tetrandrine
310 il-13
311 role myeloperoxidase
312 oxygen radical
313 expression e selectin
314 azathioprine
315 met leu phe
316 halide system
317 galactosamine induced
318 fmlp
319 cd4 t cell
320 role nitric oxide
321 mannan binding
322 interleukin il
323 dexmedetomidine
324 cell adhesion molecule-1
325 delta t cell
326 cd4 t
327 sulfamethoxazole trimethoprim
328 peripheral benzodiazepine
329 role p38 mapk
330 binding protein lbp
331 cdna microarray
332 receptor-2
333 cyclosporine
334 lipoteichoic acid
335 interleukin-1 receptor associated
336 cytokine secretion
337 anti inflammatory activity
338 chemokine expression
339 apocynin
340 leukotriene
341 superoxide production
342 monokine
343 cannabinoid
344 cefuroxime
345 interleukin-4
346 enoxacin
347 prostaglandin production
348 receptor fprl1
349 h pylori
350 lif
351 flunixin meglumine
352 integrin dependent
353 endotoxin tolerance
354 fc gamma receptor
355 hbsag
356 regulation toll receptor
357 cftr
358 kinase pathway
359 activating protein helicobacter
360 protein 1alpha ccl3
361 eicosanoid
362 dirithromycin
363 g csf
364 neutrophil actin
365 human beta defensin
366 lansoprazole
367 effect carvedilol
368 interleukin-1 alpha
369 alpha 1-proteinase inhibitor
370 clindamycin
371 antiphospholipid antibody
372 synaptotagmin
373 bronchial epithelial cell
374 antiretroviral
375 urokinase receptor
376 macrophage inflammatory protein-1
377 murine peritoneal
378 gelatinase
379 cytokine level
380 retinoic acid syndrome
381 cd18 integrin
382 nitric oxide donor
383 release leukotriene b4
384 fragment bactericidal permeability
385 amoxycillin
386 lomefloxacin
387 il-8 receptor
388 neutrophil cytoplasmic antibody
389 vitronectin
390 toll
391 calcium pyrophosphate dihydrate
392 macrolide
393 role cytokine
394 interleukin-1 interleukin-6
395 interleukin-8 production
396 alpha tnf
397 carrageenan induced
398 prodigiozan
399 oxidase activation
400 dc sign
401 protein s100a8
402 acetaminophen induced liver
403 ozone induced airway
404 natural killer t
405 protein lbp
406 activated protein
407 ifn gamma
408 role tnf receptor
409 chemokine production
410 antineutrophil cytoplasmic antibody
411 superantigen
412 antirheumatic
413 gamma interferon
414 intravenous immunoglobulin
415 injury induced lipopolysaccharide
416 3-kinase
417 protein-2
418 polymorphonuclear leukocyte oxidative
419 amyloid p component
420 bleomycin induced
421 role chemokine
422 chemoattractant
423 il-6 soluble
424 endogenous glucocorticoid
425 dextran sodium sulfate
426 interleukin
427 cd11b cd18 integrin
428 lung cytokine
429 inhibitory factor lif
430 human neutrophil oxidative
431 amyloid p
432 mpo
433 effect capsular polysaccharide
434 il-8 il-6
435 leukocytic pyrogen
436 cyclosporin
437 il-1ra
438 immunoglobulin complement
439 neutrophil chemotactic factor
440 leukotriene b4 synthesis
441 activating factor paf
442 danofloxacin
443 soluble intercellular adhesion
444 imipenem cilastatin
445 murine lyme
446 binding lectin
447 interleukin-1
448 toll receptor tlr4
449 protein cd14
450 interleukin-1beta tumor necrosis
451 carbon tetrachloride induced
452 cpg
453 neutrophil superoxide anion
454 fluconazole
455 hyper ige
456 igg iga
457 tgf beta
458 c1q
459 conjugate vaccine
460 endothelin-1
461 technetium-99m hmpao
462 human lipopolysaccharide binding
463 sphingosine 1-phosphate
464 igg complement receptor
465 tnf receptor i
466 monosodium urate
467 serum amyloid p
468 flagellin
469 capsular polysaccharide
470 alpha tnf alpha
471 light chain kinase
472 neutrophil cytoplasmic autoantibody
473 transmembrane conductance regulator
474 crystal induced
475 peritoneal dialysis solution
476 tgf beta1
477 il-3 il-5
478 superoxide anion
479 il-17
480 ulinastatin
481 curosurf
482 lipopolysaccharide cytokine
483 binding lectin mbl
484 smoke induced
485 cytokine activated
486 icam-1 expression
487 chemotactic activating factor
488 cyclooxygenase lipoxygenase
489 antipyretic
490 cigarette smoke
491 liver x receptor
492 lymphotoxin
493 interleukin-6
494 transcription factor nf
495 apoptosis inducing ligand
496 immunomodulatory activity
497 inflammation antioxidant
498 nuclear factor
499 effect inhaled endotoxin
500 nitric oxide production
501 prostanoid
502 cytokine mediated
503 anti myeloperoxidase antibody
504 superoxide anion production
505 erk
506 phagocyte nadph oxidase
507 regulation cytokine
508 cytoplasmic autoantibody
509 cytokine balance
510 staphylococcus aureus peptidoglycan
511 complement neutrophil
512 activity methanolic
513 murine klebsiella pneumonia
514 betamethasone
515 fosfomycin
516 methionyl leucyl phenylalanine
517 opsonized zymosan
518 immunomodulatory effect
519 oxidative damage
520 generation leukotriene
521 tobramycin
522 transforming growth factor
523 janus kinase
524 mip-1alpha mcp-1
525 carprofen
526 effect cyclosporin
527 receptor tlr tlr4
528 protein kinase cascade
529 fluoroquinolone
530 activation mitogen activated
531 recombinant interleukin-1
532 recombinant interleukin
533 paf
534 gm csf
535 serine protease
536 ivig
537 pro inflammatory cytokine
538 lipoxygenase
539 cefixime
540 role superoxide
541 stem bark
542 effect cyclosporin a
543 igg immune complex
544 111in oxine
545 receptor inflammation
546 pro resolving
547 factor kappa b
548 kawasaki
549 peripheral benzodiazepine receptor
550 interleukin-8 release
551 production il-8
552 alpha lymphotoxin alpha
553 terminal fragment bactericidal
554 eicosapentaenoic
555 cyclosporine a
556 tnf alpha
557 nuclear factor kappa
558 oxide tnf alpha
559 artemisinin
560 pancreatic stellate cell
561 sulfamethoxazole
562 co glycolide microsphere
563 formyl
564 effect inflammatory cytokine
565 integrin mediated
566 cd4
567 il-22
568 smoke exposure
569 derived serine protease
570 antenatal betamethasone
571 involvement nitric oxide
572 cyclo oxygenase
573 factor lif
574 immunomodulatory
575 cefotaxime
576 lymphotoxin alpha
577 tyrosine phosphorylation
578 pertussis toxin inhibit
579 kinin
580 tactivin
581 fc
582 inflammatory mediator
583 omega nitro l-arginine
584 diclofenac ketoprofen
585 alphambeta2 integrin
586 fluid cytokine
587 mitogen
588 activation cytokine
589 intercellular adhesion
590 nitric oxide tnf
591 gadolinium chloride
592 adenosine receptor
593 endotoxin induced liver
594 inhibitor human neutrophil
595 granulocyte elastase
596 hematopoietic growth factor
597 enalapril
598 binding protein cd14
599 growth factor beta
600 phorbol myristate acetate
601 chemokine response
602 interleukin-10 inhibit
603 cytokine murine
604 production chemokine
605 oxygen species
606 pro inflammatory response
607 pulmonary alveolar macrophage
608 leukocyte inhibitory factor
609 phosphoinositide 3-kinase
610 filgrastim
611 ozone induced lung
612 proteinase activated
613 cox-2 gene expression
614 defensin-1
615 cytoplasmic autoantibody anca
616 meglumine
617 endotoxic
618 beta lactam antibiotic
619 serum immunoglobulin
620 x receptor
621 oxygen metabolism
622 calreticulin
623 murine lyme arthritis
624 detection lactoferrin
625 mrna expression
626 cold restraint stress
627 ceftriaxone
628 active cytomegalovirus infection
629 propofol
630 interleukin-3
631 il-5
632 acute phase protein
633 neutrophil peptide
634 minocycline
635 p38 kinase
636 receptor igg
637 tgf
638 urokinase plasminogen
639 ifn
640 fcgamma receptor
641 non steroid anti
642 trimethoprim
643 crp
644 macrolide antibiotic
645 leucocyte integrin
646 alpha 2-macroglobulin
647 effect ciprofloxacin
648 inhibition inducible nitric
649 chemotactic factor inactivator
650 anticardiolipin antibody
651 endotoxin induced cytokine
652 pasteurella haemolytica a1
653 receptor advanced glycation
654 receptor mrna bronchial
655 cefmetazole
656 antiglomerular
657 high dose methylprednisolone
658 antibacterial activity
659 platelet activating factor
660 reactive oxygen
661 induction cytokine
662 crystal
663 proteinase activated receptor-2
664 cell cytokine
665 3-kinase gamma
666 lysosomal enzyme
667 alpha nitric oxide
668 function monocyte chemoattractant
669 chemokine ligand
670 interleukin production
671 ceftizoxime
672 cytokine pattern
673 fish oil
674 modulation cytokine
675 streptozotocin induced diabetic
676 arsenic trioxide
677 neutrophil gelatinase
678 murine experimental autoimmune
679 inhibitor nitric oxide
680 igg receptor
681 human neutrophil peptide
682 effect pentoxifylline
683 interferon gamma
684 scavenging reactive oxygen
685 microcystin
686 endotoxin induced lung
687 proinflammatory cytokine human
688 methylenedioxymethamphetamine
689 kininogen
690 pro inflammatory
691 selectin mediated
692 monosodium
693 memory cd8 t
694 serum amyloid a

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AB literature   B-term   BC literature   Neutrophils and innate immuni... p38 mitogen acute inflammatory 1: A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase. 2002 Add to clipboard 2: Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase. 2000 Add to clipboard 3: Nonopsonic binding of type III Group B Streptococci to human neutrophils induces interleukin-8 release mediated by the p38 mitogen-activated protein kinase pathway. 2000 Add to clipboard 4: Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules. 2000 Add to clipboard 5: Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils. 1998 Add to clipboard   1: KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. 2010 Add to clipboard 2: Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. 2009 Add to clipboard 3: p38 Mitogen-activated protein kinase up-regulates LPS-induced NF-kappaB activation in the development of lung injury and RAW 264.7 macrophages. 2006 Add to clipboard 4: Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases. 2005 Add to clipboard 5: Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase. 2005 Add to clipboard 6: Reduced p38 mitogen-activated protein kinase in donor grafts accelerates acute intestinal graft-versus-host disease in mice. 2005 Add to clipboard 7: p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses. 2004 Add to clipboard 8: Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. 2004 Add to clipboard 9: Anti-inflammatory potency of FR167653, a p38 mitogen-activated protein kinase inhibitor, in mouse models of acute inflammation. 2002 Add to clipboard 10: Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. 2002 Add to clipboard 11: Role of ERK and p38 mitogen-activated protein kinase cascades in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. 2001 Add to clipboard 12: Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndrome. 2000 Add to clipboard 13: C-reactive protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement. 1999 Add to clipboard

 

 

 

 

 

 

 

 

 

 

 

 

 

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