许培扬博客分享 http://blog.sciencenet.cn/u/xupeiyang 跟踪国际前沿 服务国内科研

博文

缺氧诱导因子与肿瘤研究的基因知识发现

已有 4173 次阅读 2010-12-29 14:40 |个人分类:知识发现|系统分类:论文交流| 肿瘤, 基因, 知识发现, 缺氧诱导因子

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature
  A-query: hypoxia-inducible factor
C-query: carcinoma
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1223 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 3251 and can be accessed from the start page after you leave this session. There are 1421 terms on the current B-list (523 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 3251 started Wed Dec 29 02:03:30 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
3251 Search ARROWSMITH A
A_query_raw: hypoxia-inducible factorWed Dec 29 02:03:47 2010

A query = hypoxia-inducible factor started Wed Dec 29 02:03:48 2010
A query resulted in 7752 titles
3251 Search ARROWSMITH C
C_query_raw: carcinoma Wed Dec 29 02:04:01 2010

C: carcinoma 596073

A: pubmed_query_A 7752

AC: ( hypoxia-inducible factor ) AND ( carcinoma ) 1223

C query = carcinoma started Wed Dec 29 02:04:05 2010
C query resulted in 50000 titles
A AND C query resulted in 1223 titles
14442 B-terms ready on Wed Dec 29 02:07:27 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1421 B-terms left after filter executed Wed Dec 29 02:21:56 2010

B-list on Wed Dec 29 02:23:04 2010
1 adiponectin
2 endostatin
3 brca1
4 cox-2
5 toll receptor
6 jnk
7 wnt
8 hepcidin
9 tlr4
10 mdm2
11 e2f1
12 akt
13 vegf
14 p300 cbp
15 angiopoietin
16 cd133
17 mek1
18 vegf c
19 single nucleotide polymorphism
20 mtor
21 fdg
22 stat3
23 erk1
24 angiopoietin-2
25 vegfr-2
26 beta catenin
27 cancer gene therapy
28 smad
29 egr-1
30 caspase-3
31 ppargamma
32 abcg2
33 p27kip1
34 signal regulated kinase
35 sonic hedgehog
36 caspase
37 bhlh
38 hippel lindau gene
39 c jun nh2-terminal
40 vhl gene
41 eralpha
42 flk-1
43 phosphatidylinositol 3-kinase
44 braf
45 pi3k
46 her2
47 kruppel factor
48 erbb-2
49 ctgf
50 target rapamycin
51 cxcr4
52 pten
53 vhl
54 estrogen receptor beta
55 metastasis suppressor
56 survivin
57 mmp-2
58 estrogen receptor alpha
59 caspase-8
60 gene vegf
61 bcl xl
62 mlh1
63 bcrp
64 stat1
65 mcl-1
66 bnip3
67 caix
68 microrna
69 trefoil factor
70 socs3
71 cbp
72 cyp1a1
73 cip1
74 stk11
75 mdr1
76 signal regulated
77 cd105
78 c jun
79 angiogenic gene
80 p38 mapk
81 p42
82 mek
83 p300
84 creb
85 telomerase reverse transcriptase
86 p27
87 inos
88 amphiregulin
89 plgf
90 e2f-1
91 microsatellite
92 gene promoter
93 cyclin d1
94 rack1
95 ampk
96 lkb1
97 map kinase
98 bax
99 her-2 neu
100 ets-1
101 matrix metalloproteinase
102 helix loop helix
103 leptin
104 sp1
105 vegfr
106 autotaxin
107 aryl hydrocarbon receptor
108 gstt1
109 jab1
110 chemokine receptor
111 e cadherin
112 galectin-1
113 galectin-3
114 foxo3a
115 il-8
116 lindau tumor suppressor
117 c myc
118 circadian gene
119 hur
120 p53 gene
121 erythropoietin receptor
122 tlr2
123 vegf a
124 pedf
125 waf1
126 smad3
127 ca9
128 her2 neu
129 adrenomedullin
130 mmp-9
131 apurinic apyrimidinic endonuclease
132 exon
133 sdhb
134 nrf2
135 genome wide
136 kai1
137 ccn2
138 4e bp1
139 c met
140 jak2
141 bcl-2
142 growth factor gene
143 her-2
144 p38
145 p66shc
146 notch1
147 core promoter
148 annexin
149 kdr
150 nfat
151 chemokine
152 nf kappab
153 glucose transporter
154 receptor tyrosine kinase
155 ccr7
156 equilibrative nucleoside transporter
157 ets
158 polymorphism promoter
159 endoglin
160 hif-1alpha
161 nur77
162 tumor suppressor gene
163 bcl
164 ape1
165 ndrg1
166 sdf-1
167 importin
168 sox9
169 n myc
170 carbonic anhydrase ix
171 rac1
172 cyr61
173 shc
174 ing4
175 bmi1
176 survivin gene
177 tgfbeta
178 vegf d
179 histone deacetylase
180 il-6
181 candidate tumor suppressor
182 foxo
183 multiple endocrine neoplasia
184 stathmin
185 gsk3beta
186 heparanase
187 hepatocyte growth factor
188 cadherin
189 pai-1
190 ap-1
191 mitf
192 hla g
193 rhoa
194 ghrelin
195 hif-2alpha
196 notch3
197 pgc-1alpha
198 cap43
199 pim-1
200 socs
201 p44
202 ubiquitin
203 integrin linked kinase
204 leptin receptor
205 emmprin
206 topoisomerase
207 sphingosine kinase
208 inducible gene
209 targeted gene
210 vegfr2
211 pdgf b
212 transcription factor
213 c src
214 cancer gene
215 glut-1
216 mage
217 fak
218 glycogen synthase
219 necdin
220 pin1
221 nqo1
222 hsp90
223 wt1
224 glut1
225 furin
226 cbp p300
227 cd8
228 leukemia inhibitory factor
229 hdac1
230 hipk2
231 cxcr2
232 src
233 erbeta
234 response element
235 e2f
236 vegf gene
237 polo kinase
238 egfr
239 cxcl12
240 autophagy
241 xiap
242 erk
243 hdac
244 runx2
245 glycogen synthase kinase
246 parp-1
247 mkp-1
248 abca1
249 cullin
250 b raf
251 casein kinase
252 tyrosine kinase
253 gene colorectal
254 tgf beta1
255 thioredoxin
256 nherf1
257 erbb2
258 promoter activity
259 tgf beta
260 p glycoprotein
261 dj-1
262 cyclin
263 toll
264 trkb
265 jnk1
266 fadd
267 hif
268 c ebpalpha
269 cd151
270 gene silencing
271 han
272 netrin-1
273 igfbp-3
274 apelin
275 gene-1
276 cxcl8
277 cd34
278 jun
279 zinc finger protein
280 ndrg2
281 cell cycle progression
282 vhl inactivation
283 astrocyte elevated gene-1
284 oncogenic kras
285 ink4a
286 sumo-1
287 estrogen receptor
288 activating transcription factor
289 cited2
290 rnai
291 neuroglobin
292 apoptotic gene
293 cell adhesion molecule
294 c kit
295 dna repair gene
296 arnt2
297 aquaporin
298 adeno
299 atm
300 hdm2
301 canstatin
302 fatty acid synthase
303 serum response factor
304 mdr1 gene
305 klf6
306 tumor suppressor
307 cyclophilin
308 p21
309 snp
310 presenilin
311 expression e
312 neurotrophin
313 estrogen related receptor
314 p63
315 myc
316 gene breast
317 foxm1
318 hypoxia regulated
319 p70s6k
320 myd88
321 peroxisome
322 egf
323 signal regulated protein
324 akt1
325 nadph oxidase
326 topoisomerase i
327 p53
328 midkine
329 hedgehog
330 early growth response
331 ezh2
332 ret
333 promoter region
334 factor gene
335 runx1
336 androgen receptor
337 ccaat enhancer binding
338 notch
339 pkb
340 metastasis suppressor gene
341 loxl2
342 caspase-9
343 erbb
344 ck2
345 trefoil
346 mutation vhl gene
347 gene upregulated
348 neu
349 ikkbeta
350 akt pkb
351 pkb akt
352 lipocalin
353 ccl20
354 oncogene
355 nuclear localization signal
356 il-18
357 emt
358 pparalpha
359 trail
360 g gt
361 telomerase gene
362 enhancer
363 iodide symporter gene
364 prostaglandin e synthase
365 c ebp
366 sirt1
367 erythropoietin
368 gene gastric
369 dlc1
370 cdna
371 ews
372 lysyl oxidase
373 nox4
374 ang-1
375 eif3e
376 raf
377 ankyrin
378 hsp70
379 zo-1
380 timp-1
381 sox17
382 pro apoptotic gene
383 ephrin
384 angiotensin receptor
385 yy1
386 gene associated
387 suppressor gene
388 urotensin receptor
389 igfbp-1
390 gene breast cancer
391 overexpression egfr
392 c jun n
393 cul2
394 p14arf
395 tie2
396 shh
397 ps2
398 pai-1 gene
399 heat shock protein
400 bfgf
401 3'-untranslated region
402 tumor suppression
403 reptin
404 epidermal growth factor
405 wilm tumor suppressor
406 tie-2
407 reporter gene
408 tnfalpha
409 c ebp alpha
410 related gene
411 oct-4
412 phd1
413 her-2 neu oncogene
414 gene lung cancer
415 ccn1
416 opioid receptor
417 s6
418 ho-1
419 integrin
420 decoy
421 vegfa
422 csn5
423 reck
424 breast cancer gene
425 cd69
426 activator inhibitor-1 gene
427 nude
428 chaperone
429 chaperonin
430 h19
431 pkc
432 dec1
433 beta tubulin
434 thioredoxin reductase
435 s100a4
436 egln2
437 j2
438 thymidine kinase gene
439 statin
440 mri
441 ikappab
442 e1a
443 bak
444 vegf b
445 carbonic anhydrase
446 mcp-1
447 xrcc4
448 hgf
449 insulin growth factor
450 swi snf
451 m30
452 nf
453 phd2
454 fractalkine
455 gene family
456 pet
457 ahr
458 fgf
459 pml
460 gene lung
461 expression gene
462 endocan
463 gene hypoxic
464 hsp27
465 igf
466 micb
467 foxo4
468 repressor
469 isoform
470 transporter gene
471 ephrinb2
472 id2
473 endonuclease g
474 pcr
475 cd55
476 pdcd4
477 glut3
478 rhob a
479 vhl loss
480 pthrp
481 ikkalpha
482 sparc
483 urocortin
484 endothelin
485 arnt2 gene
486 promoter
487 receptor gene expression
488 specific promoter
489 gene human
490 kv1
491 cytoglobin
492 m promoter
493 il-1beta
494 polo
495 tissue inhibitor metalloproteinase
496 mda
497 receptor gene
498 transgene
499 glioma
500 tumor suppressor von
501 ros
502 cx3cr1
503 ephb4
504 factor beta1 gene
505 gene patient
506 adamts1
507 prolyl isomerase pin1
508 codon
509 flt1
510 kinase gene
511 ags
512 neu oncogene
513 laminin
514 rb
515 dna binding
516 meningioma
517 cpg
518 eif2alpha
519 mmp-1
520 thymosin
521 slc19a3
522 transporter
523 occludin

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

hypoxia-inducible factor brca1 carcinoma
1: BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression. 2009
Add to clipboard

2: High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer. 2008
Add to clipboard

3: BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression. 2006
Add to clipboard

4: Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. 2005
Add to clipboard

 

1: CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors. 2010
Add to clipboard

2: The prognostic significance of ERCC1, BRCA1, XRCC1, and betaIII-tubulin expression in patients with non-small cell lung cancer treated by platinum- and taxane-based neoadjuvant chemotherapy and surgical resection. 2010
Add to clipboard

3: Elevated expression of Ki-67 identifies aggressive prostate cancers but does not distinguish BRCA1 or BRCA2 mutation carriers. 2010
Add to clipboard

4: Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. 2010
Add to clipboard

5: BRCA1 protein and nucleolin colocalize in breast carcinoma tissue and cancer cell lines. 2010
Add to clipboard

6: Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan. 2010
Add to clipboard

7: Transcriptional regulation of the base excision repair pathway by BRCA1. 2010
Add to clipboard

8: Low-grade adenosquamous carcinoma of the breast-A case report with a BRCA1 germline mutation. 2010
Add to clipboard

9: Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin. 2010
Add to clipboard

10: Four new cases of double heterozygosity for BRCA1 and BRCA2 gene mutations: clinical, pathological, and family characteristics. 2010
Add to clipboard

11: Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. 2010
Add to clipboard

12: Risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers. 2010
Add to clipboard

13: CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer. 2010
Add to clipboard

14: Prevalence of BRCA1 and BRCA2 germ line mutations among women with carcinoma of the fallopian tube. 2010
Add to clipboard

15: [BRCA1 selectively regulates the expression of progesterone receptor A in sporadic invasive ductal breast carcinoma.] 2010
Add to clipboard

16: The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations. 2010
Add to clipboard

17: Impact of RING and BRCT Domain Mutations on BRCA1 Protein Stability, Localization and Recruitment to DNA Damage. 2010
Add to clipboard

18: BRCA1 expression in triple negative sporadic breast cancers. 2010
Add to clipboard

19: Prioritizing Candidate Genetic Modifiers of BRCA1 and BRCA2 Using a Combinatorial Analysis of Global Expression and Polymorphism Association Studies of Breast Cancer. 2010
Add to clipboard

20: Enhanced Mismatch Mutation Analysis: Simultaneous Detection of Point Mutations and Large Scale Rearrangements by Capillary Electrophoresis, Application to BRCA1 and BRCA2. 2010
Add to clipboard

21: Development of a Scoring System to Screen for BRCA1/2 Mutations. 2010
Add to clipboard

22: Developing Functional Assays for BRCA1 Unclassified Variants. 2010
Add to clipboard

23: Evaluation of the Contribution of the Three Breast Cancer Susceptibility Genes CHEK2, STK11, and PALB2 in Non-BRCA1/2 French Canadian Families with High Risk of Breast Cancer. 2010
Add to clipboard

24: BRCA1 and BRCA2 families and the risk of skin cancer. 2010
Add to clipboard

25: Immunohistochemical expression of brca1 protein in invasive ductal carcinoma of the breast. 2010
Add to clipboard

26: Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation. 2010
Add to clipboard

27: The rate of the predominant Jewish mutations in the BRCA1, BRCA2, MSH2 and MSH6 genes in unselected Jewish endometrial cancer patients. 2010
Add to clipboard

28: Double heterozygosity in the BRCA1 and BRCA2 genes in the Jewish population. 2010
Add to clipboard

29: Prevalence of BRCA1 and BRCA2 Mutations in Women with Breast Carcinoma In Situ and Referred for Genetic Testing. 2010
Add to clipboard

30: High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. 2009
Add to clipboard

31: High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast cancers. 2009
Add to clipboard

32: Histopathological criteria and selection algorithms for BRCA1 genetic testing. 2009
Add to clipboard

33: Platinum sensitivity in a BRCA1 mutation carrier with advanced breast cancer. 2009
Add to clipboard

34: Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma. 2009
Add to clipboard

35: XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression. 2009
Add to clipboard

36: Ductal lavage in women from BRCA1/2 families: is there a future for ductal lavage in women at increased genetic risk of breast cancer? 2009
Add to clipboard

37: Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast in BRCA1 carrier. 2009
Add to clipboard

38: Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. 2009
Add to clipboard

39: BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer. 2009
Add to clipboard

40: Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers. 2009
Add to clipboard

41: Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing. 2009
Add to clipboard

42: Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers. 2009
Add to clipboard

43: [Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas] 2009
Add to clipboard

44: Prospective study of breast MRI in BRCA1 and BRCA2 mutation carriers: effect of mutation status on cancer incidence. 2009
Add to clipboard

45: A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population. 2009
Add to clipboard

46: Identification of a de novo BRCA1 mutation in a woman with early onset bilateral breast cancer. 2009
Add to clipboard

47: Clinical significance of epigenetic inactivation of hMLH1 and BRCA1 in Tunisian patients with invasive breast carcinoma. 2009
Add to clipboard

48: Breast-Conserving Surgery in BRCA1/2 Mutation Carriers: Are We Approaching an Answer? 2009
Add to clipboard

49: BRCA1 expression in invasive breast carcinomas and clinicopathological correlations. 2009
Add to clipboard

50: Repeat chemosensitivity of epithelial ovarian carcinoma in a BRCA1 mutation carrier to paclitaxel/platinum combination chemotherapy. 2009
Add to clipboard

51: [Mutations in the BRCA1 gene (185delAG and 5382insC) are not present in any of the 30 breast cancer patients analyzed from eastern Colombia] 2009
Add to clipboard

52: [BRCA1- and BRCA2- associated breast carcinomas] 2009
Add to clipboard

53: MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary. 2009
Add to clipboard

54: High-risk human papilloma virus infection, tumor pathophenotypes, and BRCA1/2 and TP53 status in juvenile breast cancer. 2009
Add to clipboard

55: Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions. 2009
Add to clipboard

56: High-throughput resequencing in the diagnosis of BRCA1/2 mutations using oligonucleotide resequencing microarrays. 2009
Add to clipboard

57: UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer. 2009
Add to clipboard

58: Changes in the Mouse Estrus Cycle in Response to Brca1 Inactivation Suggest a Potential Link between Risk Factors for Familial and Sporadic Ovarian Cancer. 2009
Add to clipboard

59: [Inactivation of BRCA1, BRCA2 and p53 genes in sporadic ovarian cancer] 2008
Add to clipboard

 

 

 

 

 

 

 

 



https://blog.sciencenet.cn/blog-280034-398762.html

上一篇:蛋白酶体抑制剂治疗多发性骨髓瘤研究的基因知识发现
下一篇:2010年许培扬的博客生活
收藏 IP: .*| 热度|

0

发表评论 评论 (0 个评论)

数据加载中...
扫一扫,分享此博文

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2024-6-16 22:47

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部