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“渐冻症”患者被称为清醒的“植物人”,世界卫生组织将其与癌症和艾滋病等并称为五大绝症。“渐冻症”患者通常存活2年至5年,最终因呼吸衰竭而死,目前尚无根治方法。
AlS病,全称叫“肌肉萎缩性侧面硬化病”,英国人也叫“运动神经细胞病”。这是无法治愈而且致命的病。史蒂芬·霍金也是得这种病。ALS病(肌萎缩性侧索硬化症)是一种运动神经元疾病,常在病后3~5年内死亡。多数国家ALS的患病率为5/10万~7/10万(3),高的可达40/10万,太平洋关岛地区为该病的高发区,中国尚无较准确的统计资料。发病年龄(成人型)20~80岁,平均57岁,男患者倍于女性。
"卢伽雷氏病”(即肌萎缩性脊髓侧索硬化症)
不少名人也曾患过这种病,如:斯蒂芬·威廉·霍金
主要症状是运动神经坏死和肌肉萎缩。
肌萎缩侧索硬化症( amyotrophic lateral sclerosis,ALS)(OMIM 105400)是一种运动神经元病,也是四大常见的神经退行性疾病之一(其它三种为亨廷顿氏病、老年性痴呆症、帕金森氏病)。本病发病率约5人/10万,男女患者之比约 3:1, 约10%的患者有家族遗传史。其遗传方式可以是常染色体显性或隐性。该病又被称为Lou Gehrig病(卢伽雷病),是因为美国历史上著名的棒球手Lou Gehrig患有此病而得名。英国著名物理学家霍金也患有此病。
http://www.gopubmed.org/web/gopubmed/1?WEB015auboipl8myjI8IdI0
amyotrophic lateral sclerosis
12,731 documents semantically analyzed
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Neurology |
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J Neurol Sci |
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Amyotroph Lateral Scler |
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Amyotroph Lateral Sc |
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Muscle Nerve |
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Ann Neurol |
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Rinsho Shinkeigaku |
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Acta Neuropathol |
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Arch Neurol-chicago |
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Rev Neurol-france |
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J Neurochem |
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J Neurol |
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Acta Neurol Scand |
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Neurosci Lett |
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J Neurol Neurosur Ps |
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Exp Neurol |
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J Biol Chem |
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Brain Res |
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Zh Nevropatol Psikhiatr Im S S Korsakova |
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J Neuropath Exp Neur |
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Amyotrophic Lateral Sclerosis |
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Motor Neuron Disease |
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Sclerosis |
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Mice |
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Neurodegenerative Diseases |
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spinal cord development |
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Top Authors
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Leigh P |
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Ludolph A |
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Appel S |
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Meininger V |
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Hirano A |
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Beal M |
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Shaw P |
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Cleveland D |
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Robberecht W |
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Sobue G |
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Rowland L |
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Strong M |
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Kurland L |
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Andersen P |
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Rothstein J |
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Ikeda K |
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Brown R |
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Iwasaki Y |
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Eisen A |
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Abe K |
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