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Douglas L. Coleman的论文被引用情况（2010年生理学或医学诺贝尔奖得主预测）
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2010年诺贝尔奖得主预测
位于美国缅因州巴港的杰克逊实验室 名誉高级科研人员 Douglas L. Coleman
获奖原因
因发现调节食欲和新陈代谢的激素致轻素而获奖
DL Coleman - Diabetologia, 1978 - Springer
Summary. The diabetes syndromes produced by the two single gene mutations, obese (ob),
and diabetes (db) are identical when both genes are expressed on the same inbred
background, whereas on different backgrounds the syndrome changes from a severe- ...
Cited by 770 - Related articles - All 2 versions
Summary. The diabetes syndromes produced by the two single gene mutations, obese (ob),
and diabetes (db) are identical when both genes are expressed on the same inbred
background, whereas on different backgrounds the syndrome changes from a severe- ...
Cited by 770 - Related articles - All 2 versions
DL Coleman, RW Schwizer, EH Leiter - Diabetes, 1984 - Am Diabetes Assoc
Dehydroepiandrosterone (DHEA) was fed at 0.1-0.4% in the diet to genetically diabetic
(db/db) or obese (ob/ob) C57BL/KsJ (BL/Ks) or C57BL/6J (BL/6) mice. Treatment of
BL/Ks-db/db or ob/ob mice with 0.4% DHEA prevented hyperglycemia, islet atrophy, and ...
Cited by 296 - Related articles - All 5 versions
Dehydroepiandrosterone (DHEA) was fed at 0.1-0.4% in the diet to genetically diabetic
(db/db) or obese (ob/ob) C57BL/KsJ (BL/Ks) or C57BL/6J (BL/6) mice. Treatment of
BL/Ks-db/db or ob/ob mice with 0.4% DHEA prevented hyperglycemia, islet atrophy, and ...
Cited by 296 - Related articles - All 5 versions
L Herberg, DL Coleman - Metabolism, 1977 - Elsevier
Spontaneous hyperglycemia, hyperinsulinemia and obesity are common features for at least
one period of the life-time in some strains of mice. Both genetic and environmental factors are
involved in the pathogenesis of the diabetes-like syndrome, making these strains ...
Cited by 286 - Related articles - All 2 versions
Spontaneous hyperglycemia, hyperinsulinemia and obesity are common features for at least
one period of the life-time in some strains of mice. Both genetic and environmental factors are
involved in the pathogenesis of the diabetes-like syndrome, making these strains ...
Cited by 286 - Related articles - All 2 versions
[CITATION] Diabetes-obesity syndromes in mice.
1. Diabetes. 1982;31(Suppl 1 Pt 2):1-6. Diabetes-obesity syndromes in mice. Coleman
DL. Several different rodent models are available for metabolic studies on the
development of diabetes. Although the abnormalities associated ...
Cited by 251 - Related articles
oxfordjournals.org [PDF]DL Coleman, EM Eicher - Journal of Heredity, 1990 - Am Genetic Assoc
From The Jackson Laboratory, Bar Harbor, Maine 04609. This research was funded in part by
NIH research grants DK14461 (DLC), GM20919 and RR01183 (EME). We thank Christina Gott
for originally noting the pro- genitor tubby male, Janice Southern for establishing the ...
Cited by 159 - Related articles - All 7 versions
From The Jackson Laboratory, Bar Harbor, Maine 04609. This research was funded in part by
NIH research grants DK14461 (DLC), GM20919 and RR01183 (EME). We thank Christina Gott
for originally noting the pro- genitor tubby male, Janice Southern for establishing the ...
Cited by 159 - Related articles - All 7 versions
DL Coleman - Science, 1979 - sciencemag.org
The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity-diabetes states
in homozygotes. These obesity syndromes are characterized by a more efficient conversion of
food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, ...
Cited by 94 - Related articles - All 3 versions
The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity-diabetes states
in homozygotes. These obesity syndromes are characterized by a more efficient conversion of
food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, ...
Cited by 94 - Related articles - All 3 versions
DL Coleman - Diabetologia, 1982 - Springer
Summary. The two mouse mutants, obese (ob) and diabetes (db), cause similar diabetes-obesity
syn- dromes that are characterized by a marked increase in apparent metabolic efficiency with
regard to utilizati- on of energy. A failure to thermoregulate in a normal fashion would ...
Cited by 40 - Related articles - All 3 versions
Summary. The two mouse mutants, obese (ob) and diabetes (db), cause similar diabetes-obesity
syn- dromes that are characterized by a marked increase in apparent metabolic efficiency with
regard to utilizati- on of energy. A failure to thermoregulate in a normal fashion would ...
Cited by 40 - Related articles - All 3 versions
DL Coleman, KP Hummel - Diabetologia, 1973 - Springer
... 1. Bleisch, VR, :M;ayer, J., Dickie, MM,: Familial diabetes mellitus in mice associated with insulin
re- sistance, obesity, and hyperplasia of the islets of Langerhans. Amer. J. Path. 28, 369--385
(1952). 2. Coleman, DL, ]~[ummel, KP: Studies with the mutation, diabetes, in the ...
Cited by 200 - Related articles - All 2 versions
... 1. Bleisch, VR, :M;ayer, J., Dickie, MM,: Familial diabetes mellitus in mice associated with insulin
re- sistance, obesity, and hyperplasia of the islets of Langerhans. Amer. J. Path. 28, 369--385
(1952). 2. Coleman, DL, ]~[ummel, KP: Studies with the mutation, diabetes, in the ...
Cited by 200 - Related articles - All 2 versions
DL Coleman - Diabetologia, 1973 - Springer
... 4. Coleman, DL, Hummel, K.]?.: The influence of genetic background on the expression of the
obese (o5) gene in the mouse. Diabetologia, 9, 287-- 293 (1973). 5. Haessler, HA, Crawford,
J. ]). : Alterations in the fatty acid composition of depot fat associated with obesity. Ann. RT. ...
Cited by 437 - Related articles - All 2 versions
... 4. Coleman, DL, Hummel, K.]?.: The influence of genetic background on the expression of the
obese (o5) gene in the mouse. Diabetologia, 9, 287-- 293 (1973). 5. Haessler, HA, Crawford,
J. ]). : Alterations in the fatty acid composition of depot fat associated with obesity. Ann. RT. ...
Cited by 437 - Related articles - All 2 versions
DL Coleman, DL Burkart - Diabetologia, 1977 - Springer
... 51, 598-646 (1971) 2. Marshall, NB, Andrus, SW, Mayer, J.: Organ weights in three forms of obesity.
Amer. ... Endocrinology 93, 510-513 (1973) Hummel, KP, Coleman, DL, Lane, PW: The influence
of genetic background on the expression of mutations at the dia- betes locus in the ...
Cited by 43 - Related articles - All 2 versions
... 51, 598-646 (1971) 2. Marshall, NB, Andrus, SW, Mayer, J.: Organ weights in three forms of obesity.
Amer. ... Endocrinology 93, 510-513 (1973) Hummel, KP, Coleman, DL, Lane, PW: The influence
of genetic background on the expression of mutations at the dia- betes locus in the ...
Cited by 43 - Related articles - All 2 versions
DL Coleman, KP Hummel - Diabetologia, 1974 - Springer
... 610 DL Coleman and KP Hummel: Hyperinsulinemia in Pre-Weaning Diabetes (db) Mice Insulin
resistance is a pronounced feature of diabetes mice which is recognizable as sooll as obesity
becomes apparent and which increases with age, be- coming almost total in the later ...
Cited by 77 - Related articles - All 2 versions
[CITATION] Diabetes and Obesity: Thrifty Mutants?
A limited number of reprints of this article may be obtained from he author THERE ARE NO REPRINTS
OF UNSIGNED REVIEWS ... NUTRITION REVIEWS I VOL. 36, NO. 5 MAY 1978 128 ... 150
NUTR/T/ON REWEWS I VOL. 36, NO. 5 YAY 1078
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pnas.org [PDF]DL Coleman - Proceedings of the National Academy of …, 1980 - National Acad Sciences
ABSTRACT Mice were found to convert acetone to lactate at appreciable rates. The conversion
of acetone to gluconeogenic precursors could provide additional glycolytic intermediates that
would allow the more complete utilization of lipid stores and increase survival time during ...
Cited by 21 - Related articles - All 8 versions
ABSTRACT Mice were found to convert acetone to lactate at appreciable rates. The conversion
of acetone to gluconeogenic precursors could provide additional glycolytic intermediates that
would allow the more complete utilization of lipid stores and increase survival time during ...
Cited by 21 - Related articles - All 8 versions
DL COLEMAN - Endocrinology, 1985 - Endocrine Soc
... DOUGLAS L. COLEMAN ... Two metabolites of the adrenal steroid dehy-droepiandrosterone (DHEA),
3 -hydroxyetiocholanolone and 3β-hydroxyetiocholanolone, were found to have antiobesity
properties with respect to both prevention of the development of obesity as well as ...
Cited by 31 - Related articles - All 3 versions
... DOUGLAS L. COLEMAN ... Two metabolites of the adrenal steroid dehy-droepiandrosterone (DHEA),
3 -hydroxyetiocholanolone and 3β-hydroxyetiocholanolone, were found to have antiobesity
properties with respect to both prevention of the development of obesity as well as ...
Cited by 31 - Related articles - All 3 versions
DL Coleman, KP Hummel - Diabetologia, 1967 - Springer
... 6 and 7). Degranulation of fi-cells is a consistent finding and apparently occurs as early as the
onset of obesity as it is evident in the islets of 25-day old dia- betics. ... Page 4. Vol. 3, No. 2, 1967
DL COLEMAN and KP HUmMeL." Studies with the Mutation, Diabetes 241 ...
Cited by 207 - Related articles - All 2 versions
... 6 and 7). Degranulation of fi-cells is a consistent finding and apparently occurs as early as the
onset of obesity as it is evident in the islets of 25-day old dia- betics. ... Page 4. Vol. 3, No. 2, 1967
DL COLEMAN and KP HUmMeL." Studies with the Mutation, Diabetes 241 ...
Cited by 207 - Related articles - All 2 versions
KP Hummel, DL Coleman, PW Lane - Biochemical genetics, 1972 - Springer
... Our studies emphasize the importance of genetic control in attempts to determine causes and
courses of diseases such as diabetes or obesity. ... Diabetologia 6:252. Coleman, DL, and Hummel,
KP (1967). Studies with the mutation, diabetes, in the mouse. Diabetologia 3:238. ...
Cited by 133 - Related articles - All 2 versions
... Our studies emphasize the importance of genetic control in attempts to determine causes and
courses of diseases such as diabetes or obesity. ... Diabetologia 6:252. Coleman, DL, and Hummel,
KP (1967). Studies with the mutation, diabetes, in the mouse. Diabetologia 3:238. ...
Cited by 133 - Related articles - All 2 versions
[CITATION] Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers
Cited by 34 - Related articles
WJ Malaisse, F Malaisse-Lagae, DL Coleman - Metabolism, 1968 - Elsevier
In mice rendered obese by adminitration of goldthioglucose, the pancreas increases both its
store of insulin and its capacity to secrete insulin in vitro in response to glucose and theophylline
in direct proportion to the actual body weight. In hereditarily obese mice ( ), the insulin ...
Cited by 16 - Related articles - All 2 versions
In mice rendered obese by adminitration of goldthioglucose, the pancreas increases both its
store of insulin and its capacity to secrete insulin in vitro in response to glucose and theophylline
in direct proportion to the actual body weight. In hereditarily obese mice ( ), the insulin ...
Cited by 16 - Related articles - All 2 versions
DL Coleman - Metabolism, 1983 - Elsevier
... References. DL Coleman, Diabetes-obesity syndromes in mice, Diabetes 31 (1982) (suppl 1),
pp. 1–6. View Record in Scopus | Cited By in Scopus (167). ... DL Coleman, Obesity genes:
Beneficial effects in heterozygous mice, Science 203 (1979), pp. 663–664. ...
Cited by 14 - Related articles - All 2 versions
... References. DL Coleman, Diabetes-obesity syndromes in mice, Diabetes 31 (1982) (suppl 1),
pp. 1–6. View Record in Scopus | Cited By in Scopus (167). ... DL Coleman, Obesity genes:
Beneficial effects in heterozygous mice, Science 203 (1979), pp. 663–664. ...
Cited by 14 - Related articles - All 2 versions
DL Coleman, KP Hummel - Diabetologia, 1970 - Springer
... Amer. J. Physiol. 211, 229--231 (1966). 8. l?Ialaisse, WJ, Malaisse-Lagae, F., Coleman, DL:
Insulin secretion in e:cperimental obesity. Metabolism 17, 802--807 (1968). 9. Mayer, J., French,
RG, Zighera, CF, Barrnett, RJ : Hypothalamic obesity in the mouse. ...
Cited by 27 - Related articles - All 2 versions
... Amer. J. Physiol. 211, 229--231 (1966). 8. l?Ialaisse, WJ, Malaisse-Lagae, F., Coleman, DL:
Insulin secretion in e:cperimental obesity. Metabolism 17, 802--807 (1968). 9. Mayer, J., French,
RG, Zighera, CF, Barrnett, RJ : Hypothalamic obesity in the mouse. ...
Cited by 27 - Related articles - All 2 versions
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