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睡眠与自发性脑节律研究的信息分析与基因知识发现

已有 3699 次阅读 2010-8-24 14:41 |个人分类:神经科学|系统分类:论文交流| 睡眠, 知识发现, 信息分析, 自发性脑节律

http://www.bioon.com/biology/biox/450567.shtml

Current Biology:为什么有些人可以想睡就睡?

http://www.gopubmed.org/web/gopubmed/1?WEB0h9k5yuo900yfI30I5xI0

sleep  and  Spontaneous brain rhythms

57 documents semantically analyzed
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Start A-Literature C-Literature B-list Filter Literature
A-query: Spontaneous brain rhythms
C-query: sleep
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 57 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 16591 and can be accessed from the start page after you leave this session. There are 138 terms on the current B-list (45 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 16591 started Tue Aug 24 03:02:42 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
16591 Search ARROWSMITH A
A_query_raw: Spontaneous brain rhythms Tue Aug 24 03:02:54 2010

A query = Spontaneous brain rhythms started Tue Aug 24 03:02:54 2010
A query resulted in 359 titles
16591 Search ARROWSMITH C
C_query_raw: sleep Tue Aug 24 03:03:13 2010

C: sleep 105852

A: pubmed_query_A 359

AC: ( Spontaneous brain rhythms ) AND ( sleep ) 57

C query = sleep started Tue Aug 24 03:03:14 2010
C query resulted in 50000 titles
A AND C query resulted in 57 titles
1792 B-terms ready on Tue Aug 24 03:05:56 2010

Viewed B-terms Tue Aug 24 03:06:42 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
138 B-terms left after filter executed Tue Aug 24 03:08:48 2010

B-list on Tue Aug 24 03:09:46 2010
1 clock gene
2 per1
3 5-ht7
4 meg
5 c fos
6 spike wave
7 ca1
8 gabaa
9 neurotrophin
10 gaba a
11 pten
12 scn
13 immediate early gene
14 task-3
15 oscillator
16 neuropeptide
17 fos
18 spike
19 epilepsy
20 ca3
21 locomotor activity
22 n acetyltransferase
23 clock
24 theta
25 sigh
26 gaba
27 calbindin
28 junb
29 circadian rhythm
30 rest
31 transcription factor
32 npy
33 glutamate receptor
34 ttx
35 alzheimer disease
36 alpha gene
37 lh
38 neuropeptide y
39 histidine decarboxylase
40 dark
41 hz
42 lobe
43 calcium channel
44 pup
45 potassium channel

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

Spontaneous brain rhythms clock gene sleep
1: Morphine withdrawal produces circadian rhythm alterations of clock genes in mesolimbic brain areas and peripheral blood mononuclear cells in rats. 2009
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2: Circadian rhythms in behavior and clock gene expressions in the brain of mice lacking histidine decarboxylase. 2004
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3: Periodic absence of nursing mothers phase-shifts circadian rhythms of clock genes in the suprachiasmatic nucleus of rat pups. 2003
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4: Behavioural rhythm splitting in the CS mouse is related to clock gene expression outside the suprachiasmatic nucleus. 2001
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1: Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease. 2010
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2: CLOCK gene variants associate with sleep duration in two independent populations. 2010
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3: The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents. 2010
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4: Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. 2010
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5: Circadian clock genes: Non-circadian roles in sleep, addiction, and psychiatric disorders? 2010
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6: 3111T/C clock gene polymorphism is not associated with sleep disturbances in untreated depressed patients. 2010
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7: Circadian clocks: genes, sleep, and cognition. 2010
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8: Expression of inducible nitric oxide synthase (iNOS) and period 1 (PER1) clock gene products in different sleep stages of patients with cognitive impairment. 2010
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9: Cones are required for normal temporal responses to light of phase shifts and clock gene expression. 2010
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10: Clock genes at the heart of depression. 2010
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11: Circadian rhythms and clock genes in psychotic disorders. 2010
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12: The role of mPer2 clock gene in glucocorticoid and feeding rhythms. 2009
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13: Circadian clock genes and sleep homeostasis. 2009
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14: Clock genes and metabolic disease. 2009
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15: Melatonin, circadian rhythms, and the clock genes in bipolar disorder. 2009
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16: Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients. 2008
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17: A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. 2008
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18: Clock gene dysfunction in patients with obstructive sleep apnoea syndrome. 2008
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19: Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: a possible mechanism of chemotherapy-induced circadian rhythm disturbances. 2008
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20: Interferon-gamma alters electrical activity and clock gene expression in suprachiasmatic nucleus neurons. 2008
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21: Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. 2008
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22: Genetic diversity patterns at the human clock gene period 2 are suggestive of population-specific positive selection. 2008
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23: Sleep apnoea: time to consider clock genes. 2008
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24: Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains. 2008
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25: Genetic differences in human circadian clock genes among worldwide populations. 2008
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26: A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. 2008
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27: Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters. 2008
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28: Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis. 2007
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29: Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes. 2007
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30: From circadian clock gene expression to pathologies. 2007
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31: Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration. 2007
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32: [Functional polymorphisms in clock genes and circadian rhythm sleep disorders] 2007
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33: TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. 2007
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34: From circadian rhythms to clock genes in depression. 2007
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35: A non-circadian role for clock-genes in sleep homeostasis: a strain comparison. 2007
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36: The role of circadian clock genes in mental disorders. 2007
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37: Circadian rhythms of melatonin, cortisol, and clock gene expression during simulated night shift work. 2007
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38: Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep/wake and circadian cycles. 2007
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39: The possible interplay of synaptic and clock genes in autism spectrum disorders. 2007
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40: Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the"master clock". 2006
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41: Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal. 2006
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42: Daily coordination of cancer growth and circadian clock gene expression. 2005
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43: Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism. 2005
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44: Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder. 2005
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45: Two new rare variants in the circadian";clock"gene may influence sleep pattern. 2005
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46: Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients. 2005
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47: Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation. 2005
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48: A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. 2003
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49: Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. 2003
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50: Clocks, genes and sleep. 2003
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51: Mutation screening of the human Clock gene in circadian rhythm sleep disorders. 2002
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52: Social timing, clock genes and autism: a new hypothesis. 2002
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53: Human clock genes. 2002
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54: The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects. 2002
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55: The discovery of circadian clock genes and the use of similar strategies to discover unknown genes underlying complex behaviors and brain disorders. 2001
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56: Molecular clock genes in man and lower animals: possible implications for circadian abnormalities in depression. 2000
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