研究进展：

http://www.bioon.com/biology/postgenomics/448371.shtml

Genome Res.：大脑发育和衰老研究新进展

知识发现平台：

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature

A-query: brain development and aging C-query: MicroRNA, mRNA, and protein expression The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 3 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 29223 and can be accessed from the start page after you leave this session. There are 404 terms on the current B-list (190 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

Start A-Literature C-Literature B-list Filter Literature

AB literature   B-term   BC literature   brain development and aging akt MicroRNA, mRNA, and protein ex... 1: Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation. 2009 Add to clipboard 2: Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal. 2008 Add to clipboard 3: PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. 2002 Add to clipboard   1: Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. 2010 Add to clipboard 2: Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486. 2010 Add to clipboard 3: CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. 2010 Add to clipboard 4: MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. 2009 Add to clipboard 5: MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. 2009 Add to clipboard 6: microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. 2008 Add to clipboard 7: T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. 2008 Add to clipboard

job id # 29223 started Sat Jul 31 02:23:57 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
29223 Search ARROWSMITH A
A_query_raw: brain development and agingSat Jul 31 02:24:48 2010

A query = brain development and aging started Sat Jul 31 02:24:48 2010
A query resulted in 8722 titles
29223 Search ARROWSMITH C
C_query_raw: MicroRNA, mRNA, and protein expression Sat Jul 31 02:25:24 2010

C: MicroRNA, mRNA, and protein expression 1762

A: pubmed_query_A 8722

AC: ( brain development and aging ) AND ( MicroRNA, mRNA, and protein expression ) 3

C query = MicroRNA, mRNA, and protein expression started Sat Jul 31 02:25:26 2010
C query resulted in 1762 titles
A AND C query resulted in 3 titles
2989 B-terms ready on Sat Jul 31 02:25:50 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
404 B-terms left after filter executed Sat Jul 31 02:30:40 2010

Viewed B-terms Sat Jul 31 02:31:36 2010
akt

B-list on Sat Jul 31 02:33:31 2010
1 akt
2 mtor
3 homeobox
4 wnt
5 p27kip1
6 estrogen receptor alpha
7 vegf
8 pten
9 opioid receptor
10 caspase-3
11 microrna
12 dicer
13 intronic
14 bdnf
15 neurotrophin
16 transgene
17 toll receptor
18 rna binding protein
19 cadherin
20 schizophrenia susceptibility gene
21 ephrin
22 rna binding
23 homeobox gene
24 fmr1
25 transcription factor
26 glutamate receptor
27 glucocorticoid receptor
28 hcn2
29 gene family
30 angiotensin receptor
31 dyrk1a
32 caspase-9
33 leukemia inhibitory factor
34 creb
35 bcl
36 rna gene
37 bcl w
38 bace1
39 estrogen receptor
40 untranslated region
41 pi3k
42 expression gene
43 sox4
44 cdna
45 tumor suppressor
46 cxcr4
47 3'-untranslated region
48 pten gene
49 bcl-2
50 cyclin dependent kinase
51 zeb1
52 oncogene
53 helicase
54 receptor gene
55 nf kappab
56 s100b
57 caspase
58 cyclin
59 genome wide
60 app
61 p19
62 chemokine
63 transgene expression
64 p38 mapk
65 p38
66 fos
67 proto oncogene
68 candidate gene
69 sirt1
70 expression tumor suppressor
71 ap-1
72 intron
73 igf
74 insulin growth factor
75 neurotrophic factor gene
76 isoform
77 rt
78 tumor suppressor gene
79 factor gene
80 methyltransferase
81 connexin43
82 tlr2
83 p glycoprotein
84 gene encoding
85 insulin receptor
86 ngf
87 protein kinase
88 alu
89 c kit
90 erk
91 ppargamma
92 nf
93 igf i
94 ribosomal protein
95 transporter
96 ink4a
97 enhancer
98 activin
99 notch
100 hedgehog
101 huntington disease
102 src
103 matrix metalloproteinase
104 aquaporin
105 genomic
106 ret
107 inflammatory gene
108 protein tyrosine phosphatase
109 d1
110 rna helicase
111 programmed cell death
112 neurod
113 hoxb8
114 yb-1
115 robo1
116 p27
117 alzheimer disease
118 icam-1
119 myostatin
120 rna polymerase
121 gsk-3
122 tyrosine phosphatase
123 gene expressed
124 5'-untranslated region
125 fgf
126 annexin
127 superoxide dismutase
128 glutaminase
129 protein gene
130 kinesin
131 heat shock protein
132 analysis gene
133 glycogen synthase
134 p53
135 egf
136 gene organization
137 inos
138 superoxide dismutase gene
139 igf-1
140 myosin heavy chain
141 susceptibility gene
142 rna
143 ubiquitin
144 promoter region
145 lim
146 exon
147 clock
148 cyclin d2
149 epidermal growth factor
150 huntington
151 proto
152 cytochrome p450
153 tyrosine kinase
154 fibroblast growth factor
155 related gene
156 calcium channel
157 ts1
158 pcr
159 mu
160 map
161 meningioma
162 genome
163 senescence
164 histone
165 beta actin
166 tweak
167 suppressor gene
168 abl
169 tubulin
170 promoter
171 gene hypertension
172 response element
173 cd44
174 kinase
175 hsp70
176 rev
177 glioma
178 mineralocorticoid receptor gene
179 nadph
180 dihydrofolate reductase
181 olfactory
182 inducible
183 cytochrome c oxidase
184 wilm tumor
185 associated protein
186 cytokine
187 autophagy
188 mitochondrial
189 integrin beta
190 dna polymerase

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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