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《Nature》最大的多组学研究确定了结直肠癌的新遗传景观
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《Nature》最大的多组学研究确定了结直肠癌的新遗传景观
华大基因智能医学研究所(IIMR)与瑞典乌普萨拉大学合作，发表了迄今为止最大规模的结直肠癌(CRC)多组学研究。该研究旨在了解致癌体细胞突变的功能和预后影响，揭示新的遗传改变并开发新的肿瘤变异分子分类器。这项研究发表在2024年8月7日的《Nature》杂志上。
https://www.ebiotrade.com/newsf/2024-8/20240815071233672.htm
http://www.pubmedplus.cn/P/SearchQuickResult?wd=71f1e29c-8a33-4dff-a10b-5c67cee9f907
| 01. | Humans | 4 篇 | 66.667% |
| 02. | Cell Line, Tumor | 3 篇 | 50.000% |
| 03. | Animals | 2 篇 | 33.333% |
| 04. | Colonic Neoplasms | 2 篇 | 33.333% |
| 05. | Colorectal Neoplasms | 2 篇 | 33.333% |
| 06. | Gene Expression Regulation, Neoplastic | 2 篇 | 33.333% |
| 07. | HEK293 Cells | 2 篇 | 33.333% |
| 08. | Mutation | 2 篇 | 33.333% |
| 09. | Tumor Microenvironment | 2 篇 | 33.333% |
| 10. | Adenocarcinoma | 1 篇 | 16.667% |
http://www.pubmedplus.cn/P/SearchQuickResult?wd=a4bcae39-ca7e-4b46-b2ef-dbda62a75e0f
| 01. | Humans | 98 篇 | 80.328% |
| 02. | Proteomics | 70 篇 | 57.377% |
| 03. | Genomics | 62 篇 | 50.820% |
| 04. | Precision Medicine | 55 篇 | 45.082% |
| 05. | Metabolomics | 53 篇 | 43.443% |
| 06. | Biomarkers, Tumor | 47 篇 | 38.525% |
| 07. | Colorectal Neoplasms | 36 篇 | 29.508% |
| 08. | Biomarkers | 28 篇 | 22.951% |
| 09. | Epigenomics | 22 篇 | 18.033% |
| 10. | Animals | 17 篇 | 13.934% |
http://www.pubmedplus.cn/P/SearchQuickResult?wd=4602ad17-1959-4650-8cae-99efbc7950c0
| 01. | Humans | 132 篇 | 75.862% |
| 02. | Colorectal Neoplasms | 104 篇 | 59.770% |
| 03. | Proto-Oncogene Proteins p21(ras) | 96 篇 | 55.172% |
| 04. | Mutation | 95 篇 | 54.598% |
| 05. | Female | 63 篇 | 36.207% |
| 06. | Male | 58 篇 | 33.333% |
| 07. | Biomarkers, Tumor | 55 篇 | 31.609% |
| 08. | Prognosis | 45 篇 | 25.862% |
| 09. | Middle Aged | 44 篇 | 25.287% |
| 10. | Aged | 42 篇 | 24.138% |
https://blog.sciencenet.cn/blog-280034-1447012.html
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